Bilateral Lower Limb Edema and Cellulitis Associated with Pramipexole Dihydrochloride Tablets: A Case Report

Bilateral Lower Limb Edema and Cellulitis Associated with Pramipexole Dihydrochloride Tablets: A Case Report | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 18 August 2025 V1 Latest version Share on Bilateral Lower Limb Edema and Cellulitis Associated with Pramipexole Dihydrochloride Tablets: A Case Report Authors : Chaoqiong Shi 0009-0004-7553-1102 , Weiping Yang , Qingqing Chang , Xiuping Feng , Jiaming Zhang , Yiyang Zhuang [email protected] , and Shangqing Bi Authors Info & Affiliations https://doi.org/10.22541/au.175550070.03519073/v1 187 views 49 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract A 59-year-old male patient with Parkinson’s disease developed bilateral lower limb edema accompanied by cellulitis. Laboratory investigations revealed the following: Complete blood count (CBC): White blood cell count (WBC) 10.68 × 10 9 /L, Neutrophil count 7.43 × 10 9 /L; High-sensitivity C-reactive protein (hs-CRP) 5.49 mg/L. Cardiac enzyme panel: Creatine kinase (CK) 211 U/L, Creatine kinase MB isoenzyme (CK-MB) 17 U/L. No significant abnormalities were found in: Liver function tests (7 items), Cardiac troponin I and myoglobin, Renal function and glucose, N-terminal pro-B-type natriuretic peptide (NT-proBNP), Thyroid function tests (3 items), Tumor markers (3 items), Rheumatoid factor, Anti-streptolysin O (ASO) titer, Blood culture for pathogens, Electrolytes (4 items), and D-dimer. Imaging studies: Chest CT showed bilateral pulmonary nodules, minimal inflammation in the right lower lobe, and aortic sclerosis. Echocardiography, lower extremity arterial and venous Doppler ultrasound, and abdominal plain film revealed no significant abnormalities. After screening for other etiologies based on auxiliary examinations and excluding adverse reactions to calcium channel blockers (CCBs), the presentation was attributed to an adverse drug reaction (ADR) to pramipexole. Due to personal reasons, the patient could not switch to an alternative oral medication for pramipexole. Consequently, the pramipexole dosage was reduced, and symptomatic treatments including diuresis for edema reduction, anti-infective therapy, and topical application were administered. Following treatment, the patient’s bilateral lower limb symptoms significantly improved. Supplementary Material File (bilateral lower limb edema and cellulitis associated with pramipexole dihydrochloride tablets a case report1.doc) Download 94.99 KB Information & Authors Information Version history V1 Version 1 18 August 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Affiliations Chaoqiong Shi 0009-0004-7553-1102 Guangzhou University of Chinese Medicine View all articles by this author Weiping Yang Shenzhen Traditional Chinese Medicine Hospital View all articles by this author Qingqing Chang Guangzhou University of Chinese Medicine View all articles by this author Xiuping Feng Guangzhou University of Chinese Medicine View all articles by this author Jiaming Zhang Guangzhou University of Chinese Medicine View all articles by this author Yiyang Zhuang [email protected] Shenzhen Traditional Chinese Medicine Hospital View all articles by this author Shangqing Bi Shenzhen Traditional Chinese Medicine Hospital View all articles by this author Metrics & Citations Metrics Article Usage 187 views 49 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Chaoqiong Shi, Weiping Yang, Qingqing Chang, et al. Bilateral Lower Limb Edema and Cellulitis Associated with Pramipexole Dihydrochloride Tablets: A Case Report. 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