Title：Percutaneous endoscopic interlaminar discectomy versus unilateral biportal endoscopy in the treatment of L5/S1 degeneration disease: a randomized controlled trial

Title：Percutaneous endoscopic interlaminar discectomy versus unilateral biportal endoscopy in the treatment of L5/S1 degeneration disease: a randomized controlled trial | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Title：Percutaneous endoscopic interlaminar discectomy versus unilateral biportal endoscopy in the treatment of L5/S1 degeneration disease: a randomized controlled trial Junjie Wu, Bailong Tao, Kai Li, Minghuang Cheng, Xiaohan Pan, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3892549/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Lumbar degenerative disease(LDD)is a prevalent condition that significantly impairs individuals'quality of life due to the presence of lower back and leg pain symptoms. This retrospective study was designed to compare and analyze the clinical outcomes of percutaneous endoscopic interlaminar discectomy(PEID)and unilateral biportal endoscopy(UBE) in the treatment of LDD . Methods: A total of 79 L5/S1 LDD patients admitted to the Spinal Surgery Department of the First Affiliated Hospital of Chongqing Medical University from September 2020 to May 2023 were selected and divided into Group A(PEID) and Group B(UBE) according to different surgical methods.Basic data, preoperative and postoperative lumbar and leg pain scores (as measured by the visual analogue Scale [VAS]), and functional recovery (as measured by the Dysfunction Index [ODI] score) were assessed for each group.The statistical analysis of the results from both groups was conducted using SPSS 25.0 software. Results: There were significant differences in postoperative lumbar and leg pain scores and functional impairment indexes between the two groups. Lower back pain score 1 day and 1 month after surgery in PEID group was lower than that in UBE group, and leg pain score 1 day, 1 month and 3 months after surgery in PEID group was lower than that in UBE group. The functional impairment index at 1 day, 1 month, 3 months and 6 months after operation in UBE group was lower than that in PEID group, and the difference was statistically significant (P < 0.05). Conclusion: This study suggests that although both approaches are effective in the treatment of L5/S1 degenerative diseases and can relieve back and leg pain and dysfunction, UBE is more advantageous in the treatment of central canal stenosis, and PEID is more effective in the short-term relief of back and leg pain caused by central protrusion. This may provide a basis for patients to make personalized surgical plans. Lumber degeneration disease Percutaneous endoscopic interlaminar discectomy Unilateral biportal endoscopy Background In recent years, with the changes in people's lifestyle and work style 1 , the incidence of lumbar degenerative disease (LDD) increases year by year, and the onset age decreases year by year. LDD has become the most common disease causing lumbar and leg pain in the world, seriously affecting people's quality of life 2 . The main disease categories of LDD include lumbar disc herniation, lumbar spinal stenosis, and lumbar spondylolisthesis, causing symptoms such as back and leg pain, lower limb numbness, weakness, limited movement of the lumbar spine, and intermittent claudication.Currently,surgery is widely regarded as an effective treatment for LDD 3 .It has been shown to greatly alleviate the aforementioned symptoms,enhance patients' quality of life,and facilitate the restoration of neurological function more effectively than conservative treatments.Minimally invasive surgery,in comparison to traditional surgical methods,not only preserves the stability of the posterior column structure but also boasts qualities 4 like smaller incisions,reduced local pain in the surgical area,minimal blood loss,shorter hospitalization stay period,and quicker postoperative recovery 5 . With the innovation and development of full endoscopic systems 6–7 , spinal endoscopy technology has developed into a safe, effective 8 and efficient 9 alternative to minimally invasive spinal surgery, making it possible for orthopedic surgeons to perform precise decompression surgery through the selection of different approaches 10 . At present, the main minimally invasive endoscopic techniques for the treatment of LDD 11 include percutaneous single-channel interlaminar spinal endoscopy discectomy (PEID) and transforaminal percutaneous endoscopic lumber discectomy,TF-PELD) and unilateral biportal endoscopy (UBE) 12 have been demonstrated in many clinical studies and meta-analyses to be effective and safe 13–17 . Due to the similarity of surgical approaches between PEID and UBE, they have been widely compared by global scholars 18–19 , but few have further classified LDD 20 , so as to compare the influence of the two approaches on perioperative period and prognosis. According to research reports, indications for lumbar total endoscopic surgery include lumbar disc herniation (① central ② paramedian ③ foraminal ④ extraforaminal ⑤ Migrated disc) and lumbar spinal stenosis (① lateral recess stenosis ② central canal stenosis ③ ossification of ligamentum luteum ④ foraminal stenosis) 10 .Based on the classification of LDD, the purpose of this paper is to compare the perioperative conditions, long-term and short-term effects and complications of the treatment of LDD by PEID technology and UBE technology, as well as the differences in the relief degree of LDD related symptoms between the two endoscopic surgery methods, so as to select the appropriate endoscopic surgery methods for different patients. It serves as the foundation for creating a personalized treatment plan. Materials and methods In this study,data from 79 patients with lumbar disc degeneration(LDD) who received treatment at the Spinal Surgery Department of the First Affiliated Hospital of Chongqing Medical University between September 2020 and May 2023 were retrospectively analyzed.Based on the preoperative MRI results 21 ,the participants were categorized into two groups,namely Group A and Group B.44 cases of central L5/S1 prominence in group A were treated with PEID technique. UBE technique was used in 35 cases of L5/S1 central duct stenosis in group B. The Ethics Committee of the First Affiliated Hospital of Chongqing Medical University approved this study,and informed consent was obtained from all 79 enrolled patients.All of these procedures and data records were performed by the same orthopedic surgeon who is proficient in both techniques. The inclusion and exclusion of both groups were based on the following criteria. Inclusion criteria were :( 1 ) Lumbar degenerative diseases with L5-S1 lesions (L5/S1 central herniation or central duct stenosis) were clearly diagnosed before surgery; ( 2 ) The surgical treatment was PEID or UBE; ( 3 ) They did not experience significant symptom relief after 3 months of conservative treatment before surgery;( 4 ) Complete clinical and radiological data; ( 5 ) Complete at least 1 year of follow-up. Exclusion criteria were :( 1 ) previous spinal surgery; ( 2 ) Other segmental disc herniation with instability, the lesion instability is not obvious; ( 3 ) Combined with tuberculosis, infection, tumor; ( 4 ) Combined with cauda equina syndrome symptoms; ( 5 ) Receive anticoagulant or antiplatelet drugs within 6 months; ( 6 ) There are other disease factors that affect neurological function,such as traumatic fracture, degenerative spondylolisthesis, degenerative scoliosis, etc. Surgery procedure Group A: PEID group After anesthesia, the patient was placed in a prone position, padded on the patient's abdomen, and the surgical site was routinely disinfected and covered with towels. C-arm fluoroscopy was used to locate the L5-S1 segment and puncture the affected side of the L5-S1 segment by the interlaminar approach at the paraspinal process of about 1-2cm.After the puncture position was determined by fluoroscopic examination, the needle core was pulled out and the guide wire was inserted. A longitudinal skin incision of about 1.0cm was made with the puncture needle as the center. The serial dilator was inserted alongside the guide wire, and the working cannula was positioned to ensure its tip reached the inner boundary of the lower articular process of L5,close to the ligamentum flavum.The section of the lamina of the affected side of L5 was removed from the starting point of the ligamentum flavum, and most of the ligamentum flavum was removed. Intraoperative findings: the protruding nucleus pulposus tissue compressed the S1 nerve root on the affected side, rotated the working cannula again to make the working cannula face outward, blocked the nerve root and dural sac at the tip of the tongue and pushed them inward for protection.The working cannula was then adjusted to provide better access to the nerve root axilla and shoulder,allowing for the removal of the protruding nucleus pulposus.The spinal canal was carefully examined and any free nucleus pulposus was also removed.Further investigation showed that the S1 nerve root/spinal canal on the affected side was decompression completely and relaxation activity was good.Bipolar radiofrequency electrodes were used to perform radiofrequency ablation and annulus fibroplasty. The operation field was completely hemostatic. The foraminal mirror was taken out,followed by the removal of the working cannula,and finally,a small incision was closed. Sterile dressing covers the surgical incision. Group B: UBE group After anesthesia, the patient was lying prone on the operating table, with soft cushions placed on the patient's abdomen,Furthermore,the surgical site was disinfected as per the standard procedure and towels were used to cover it.C-arm fluoroscopy was employed in order to determine the location of the L5-S1 segment.A transverse skin incision of about 1.0cm was made from the center of the L5-S1 space along the lines of the inner edge of the pedicle of L5 and S1 on the affected side,respectively,and a special dilator was used to expand the channel successively. The cephalic side was used as a mirror observation channel and the caudal side was used as an operation channel. Installed the mirror and connected it to the camera system.The lower margin of the L5 laminae and the upper margin of the S1 laminae on the affected side were first explored to confirm the L5-S1 laminae space again.The RF electrode was used to expose the ligamentum flavum, and the drill was used to remove part of the bone of the affected lamina of L5 to the stop of ligamentum flavum, inward to the base of the spinous process, and outward to the internal margin of the articular process. The same was done to the bone of the upper margin of the S1 lamina to the stop of ligamentum flavum. Floated and removed part of the ligamentum flavum. During the operation, the S1 nerve root and dural sac on the affected side were exposed by the protruding nucleus pulposus tissue under top pressure, the nerve peel was separated to reveal the nerve root, and the protruding nucleus pulposus was removed by pulling the hook to the medial side. The spinal canal was carefully investigated and the S1 nerve root and dural sac on the affected side were released. Further investigation showed that the S1 nerve root/spinal canal on the affected side was decompression completely and relaxation activity was good. Radiofrequency ablation and annulus fibroplasty were performed with bipolar radiofrequency electrodes, and the operation field was completely hemostatic. The spine endoscope was removed, then the working cannula was removed, a negative pressure drainage tube was placed into the incision, and a small incision was sutured. Sterile dressing covers the surgical incision. Precautions Close monitoring of intraoperative vital signs and ensuring proper air way protection should be prioritized. Surgical outcome All the patients had successful operation, good anesthetic effect and satisfactory hemostatic effect. After surgery, the patient returned safely to the ward. Postoperative management ( 1 ) Anti-infection, analgesia, dehydration and detumescence, neuronutrition and other treatments were given after surgery; Blood routine and blood biochemistry were reviewed the first day after surgery. ( 2 ) Guide patients to perform axial rotation and functional exercises of lower limbs during bed rest to prevent venous thrombosis of lower limbs, bedsores, hypostatic pneumonia and other long-term bed related complications . ( 3 ) The drainage flow of patients treated with UBE technology was recorded every day, and the drainage tube was removed only when the drainage flow was less than 30ml/d. ( 4 ) After the drainage tube was removed, lumbar X-ray anterior-lateral radiographs were reviewed on the same day; You can walk with a lumbar brace. ( 5 ) The patient was instructed to wear the lumbar spine brace for at least 3 months, and lumbar MRI was reviewed 1 month after surgery. Clinical indicator The fundamental information pertaining to admission and operation was documented,which encompassed age,gender,time of operation,intraoperative blood loss,duration of stay, and rate of complications.The degree of lumbar and leg pain before surgery, as well as 1 day,1 month,3 months,6 months,and 12 months after surgery, was assessed using the Visual Analogue Scale(VAS).Dysfunction index(ODI) was used to evaluate the degree of limited activity before surgery,1 day,1 month,3 months,6 months and 12 months after surgery. Statistical analysis SPSS 25.0 software was used for inter-group and intra-group comparison. Counting data were tested by chi-square test.In the measurement data, independent sample t test was used for component comparison.The paired sample t-test was utilized for the intra-group comparison with matching normal distribution,while the non-parametric test was employed for the non-matching distribution. P < 0.05 was considered statistically significant. Results Perioperative clinical data A total of 79 patients were eligible for the study based on inclusion and exclusion criteria. Based on the distinct surgical approach and LDD classification,the patients were categorized into two groups Group A and Group B.Group A consisted of 44 patients who underwent treatment for central/paracentral disc herniation of L5/S1 using the PEID technique. Group B included 35 patients with L5/S1 central duct stenosis treated with the UBE technique.There was no significant difference in age(t test)and gender(Chi-square test)between the two groups(P > 0.05). Both groups completed the operation successfully. All incisions were Grade A healing.There was no significant difference in hospitalization stay period between the two groups(p > 0.05).The duration of the operation was significantly longer in the Group B compared to the Group A(p < 0.05).The Group B had significantly higher intraoperative bleeding compared to the Group A,and this difference was found to be statistically significant(p < 0.05). The analysis findings are presented in Table 1 . Table 1 Perioperative clinical data of patients with L5/S1 intervertebral disc degeneration PEID Percutaneous endoscopic interlaminar discectomy,UBE Unilateral biportal endoscopy. Counting data were tested by chi-square test. In the measurement data, independent sample t test was used for component comparison. Curative effect evaluation VAS score of low back pain There was no significant difference in preoperative VAS scores of low back pain between the two groups (P > 0.05). The VAS scores for postoperative low back pain in both groups were significantly lower than the scores before surgery(P < 0.05).In the Group A, the VAS scores for back pain were significantly lower than the Group B at 1 day and 1 month after surgery(P 0.05). Please refer to Table 2 . VAS score for leg pain The preoperative VAS score for leg pain in the Group B was significantly lower than that in the Group A (P < 0.05).The postoperative leg pain VAS scores of the two groups were significantly lower than the preoperative scores(P < 0.05).The VAS scores of leg pain 1 day, 1 month and 3 months after surgery in the Group A were lower than those in the Group B,with statistical significance (P 0.05).The results were also as shown in Table 2 . Table 2 Comparison of the back pain and leg pain VAS between the two groups at six time-points and Intra-group comparison VAS Visual analogue scale,PEID Percutaneous endoscopic interlaminar discectomy,UBE Unilateral biportal endoscopy. In the measurement data, independent sample t test was used for component comparison. Assuming normality, ANOVA test was used and in case of non-normality, Kruskal–Wallis test was used to compare the variables in two groups. ODI index The preoperative ODI index was significantly lower in the Group A compared to the Group B (P < 0.05).The postoperative ODI index of the two groups was lower than the preoperative score, and the difference was statistically significant (P < 0.05).The ODI index for dysfunction at 1 day,1 month,3 months and 6 months after surgery was significantly lower in the Group B compared to the Group A (P 0.05).The outcomes of ODI index comparison were as indicated in Table 3 . Table 3 Comparison of the ODI between the two groups at six time-points and Intra-group comparison ODI Dysfunction index,PEID Percutaneous endoscopic interlaminar discectomy,UBE Unilateral biportal endoscopy. In the measurement data, independent sample t test was used for component comparison. Assuming normality, ANOVA test was used and in case of non-normality, Kruskal–Wallis test was used to compare the variables in two groups. Postoperative complication There was one instance of cerebrospinal fluid leakage after surgery in the PEID group.In UBE group, there were 2 cases of cerebrospinal fluid leakage after operation,and no serious complications such as nerve and blood vessel injury and wound infection occurred.The incidence of postoperative complications did not differ significantly between the two groups (P > 0.05).They all showed improvement after receiving symptomatic treatment and bed rest. Discussion Lumbar degenerative disease common in the elderly, but due to changes in life habits and way of working, the onset of degenerative disease gradually younger age, and its main divided into lumbar intervertebral disc protrusion lumbar spinal stenosis and lumbar olisthe,etc., the clinical manifestations of the disease is mainly low back pain or leg pain, numbness, weakness, intermittent claudication, with or without lower limb radiation pain, It seriously affects the quality of life of patients, and there is even a risk of cauda equina syndrome or lower limb paralysis as the disease progresses. Non-surgical treatment is usually less effective 22 , and surgical intervention is often required when the disease progresses to advanced stages 23 . In the past few decades, minimally invasive spinal surgery has been widely used, and endoscopic surgery can achieve the same therapeutic results as open surgery 24 , but with less damage to the normal spinal structure. Relevant studies have shown that open and minimally invasive surgery for degenerative diseases of the lumbar spine leads to significant changes in muscle area, and the development of muscle dysfunction in the back can disrupt the normal function of other spinal areas and may lead to further development of spinal diseases 25 .However, the endoscopic approach has less influence on the muscle groups at the surgical site, such as the paraspinatus muscle,the multifidus muscle and the erector spine muscle, than the open approach 13 .After minimally invasive endoscopic surgery, the postoperative pain was significantly relieved and the incidence of related paravertebral muscle injury was low 26 , suggesting that endoscopic surgery has a good decompression effect. In addition, the endoscopic approach has little damage to the lumbar structure and more facet joints are preserved 27 , which increases the stability of the spine and reduces the risk of spinal instability after decompression resulting in lesions of adjacent segments. Therefore, minimally invasive spinal endoscopy technology has the advantages of low surgical cost, rapid postoperative recovery and obvious improvement of postoperative symptoms 28 . Due to its special anatomical characteristics, L5/S1 segment is technically advantageous in the treatment of L5/S1 lumbar degenerative changes through posterior interlaminal approach. PEID and UBE are both interlaminal approach surgical paths, and precise decompression of nerve roots and dural sac can be performed by excising the laminae and ligamentum luteum exposed to pressure. Previous studies have shown that a large amount of invisible blood loss occurs during UBE surgery for lumbar disc herniation or spinal stenosis 29 , and operative time and target level of paracanthospinous muscle thickness are independent risk factors for invisible blood loss in patients with lumbar disorders undergoing UBE surgery 30 . Combined with this study, PEID technology and UBE technology had similar effects on normal spinal soft tissue and structure, and there was no statistical significance in spinal canal sagittal diameter and vertebral space height 3 months after surgery (P > 0.05). Therefore, the surgical trauma was minimized and the stability of the lumbar spine was maintained to the maximum extent. However, the operation time of the UBE group was longer than that of the PEID group, so we believe that the longer operation time of the UBE group increased the hidden blood loss of the operation,resulting in more blood loss in the UBE group than that of the PEID group. Clinical efficacy is an important part of surgical technology, which directly affects the decision of the surgeon and the patient. In this study, PEID and UBE showed similar relief of postoperative back and leg pain, but when compared in the UBE group, we found that the UBE technique provided more significant pain relief for central lumbar spinal stenosis than for central disc herniation. Similarly, the results of this study show that both PEID and UBE can effectively alleviate dysfunction, and UBE is more advantageous in the relief of dysfunction in central lumbar spinal stenosis. There was no significant difference in complications. However, the postoperative pain, function and quality of life of the two groups were significantly improved, suggesting that the clinical efficacy of the two surgical methods was comparable. In the study, patients in both the PEID and UBE groups successfully completed the procedure. The overall complication rate of UBE surgery for lumbar spinal stenosis was 8.1% 29–30 . Among them, dural tear is the most common complication with an incidence of about 1.5–9.7% 31–34 . While most dural tears are small and can be managed conservatively, dural tears larger than 10mm require repair to prevent cerebrospinal fluid leakage and other sequelae. Epidural hematoma is another common complication, one of the reasons may be that high intraoperative water pressure conceals the bleeding points, resulting in intraoperative visual field loss. Therefore, intraoperative irrigation water pressure should be controlled within 25-30mmHg 35 . In this study, no serious complications such as postoperative infection, nerve or vascular injury occurred in the two groups. As both PEID and UBE were minimally invasive endoscopic procedures, the lumbar vertebral structure was not significantly damaged during surgery, and the lumbar spine brace could be worn on the day after surgery to move out of bed. Therefore, none of the 79 patients had long-term bed complications such as lower limb venous thrombosis, bedsore, and hypostatic pneumonia.One case of cerebrospinal fluid leakage caused by postoperative dural tear in PEID group. Two cases of postoperative cerebrospinal fluid leakage in UBE group were improved after symptomatic treatment and bed rest. Complication rates were similar to those reported in previous studies 36–37 . The original disease recurred in both groups, and the recurrence rate (0%) was lower than that reported in previous studies 38 . In summary, both PEID technology and UBE technology can effectively treat LDD, and PEID technology has more advantages in short-term relief of back and leg pain after central protrusion, but UBE technology can effectively improve surgical efficiency in the treatment of central canal stenosis, and has the advantages of significantly improving postoperative pain symptoms and dysfunction 39–40 . It provides a basis for patients to choose the appropriate treatment plan, and is conducive to ensuring the effect of surgical treatment and prognosis. Conclusion The emergence of minimally invasive surgery has greatly accelerated the development of the treatment of spine related diseases.Different minimally invasive endoscopic techniques have different indications due to the widespread use of minimally invasive technology.The aim of this study was to examine and contrast the benefits and drawbacks of PEID and UBE for treating lumbar degenerative diseases, in order to formulate a tailored surgical strategy based on the specific condition of each patient. Although only one data set was used, these preliminary results provide some insight into the selection of appropriate surgical protocols based on the clinical typing of lumbar degenerative diseases. By comparing UBE technique with PEID technique, we found that UBE technique is more efficient than PEID technique in the treatment of lumbar spinal stenosis, and has the advantages of wider surgical field of view, fuller operation range and more adequate spinal canal decompression.While previous studies have reported on the long-term clinical safety and efficacy of these two procedures, lumbar degenerative disease classification has not kept track of more effective surgical treatments.The objective of this study is to offer patients a personalized treatment plan grounded on LDD classification.Nevertheless, the study possesses various constraints.Primarily, it was a retrospective study performed at a solitary facility and involved a limited number of participants. Therefore, we select patients treated by the same surgical group to reduce differences in surgical techniques, medical costs, and postoperative management.The data's homogeneity can partially make up for the small sample size deficiency.Additionally, the duration of follow-up in this study was limited.To confirm this finding, it is necessary to conduct larger studies and have a longer follow-up period due to the limited sample size and short follow-up time. Declarations Ethics approval and consent to participate The ethical committee of the First Afliated Hospital of Chongqing Medical University approved this retrospective study for medical research, and informed consent was obtained from all patients included in the study. All methods were carried out in accordance with the Declaration of Helsinki and its relevant guidelines and regulations. Consent for publication Not applicable. Competing interests The authors declare no conficts of interest. Availability of data and materials The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request. Funding This study received no external funding. Authors' contributions Junjie Wu designed the study, analysed the data and wrote the manuscript;Jie Hao was responsible for proofreading the manuscript; Bailong Tao, Kai Li, Minghuang Cheng, Xiaohan Pan,Xiaojun Zhang, Wei Jiang wrote the manuscript. All authors reviewed the manuscript. The author(s) read and approved the final manuscript. Acknowledgements Not applicable. Authors' information 1 Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 2 Orthopedic Laboratory of Chongqing Medical University, Chongqing, China 3 Laboratory Research Center,The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 4 Department of Orthopedics, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China References Hoffeld K, Lenz M, Egenolf P, Weber M, Heck V, Eysel P, et al. Patient-related risk factors and lifestyle factors for lumbar degenerative disc disease: a systematic review. Neurochirurgie. 2023;69(5):101482. Hoy D, Brooks P, Blyth F, Buchbinder R. The Epidemiology of low back pain. Best Pract Res Clin Rheumatol. 2010;24(6):769–81. Czabanka M, Thome C, Ringel F, Meyer B, Eicker SO, Rohde V, et al. [Operative treatment of degenerative diseases of the lumbar spine]. Nervenarzt. 2018;89(6):639–47. Ahn Y. 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Novel Instruments for Percutaneous Biportal Endoscopic Spine Surgery for Full Decompression and Dural Management: A Comparative Analysis. Brain Sci. 2020;10(8). Kim JE, Choi DJ, Park EJ. Risk Factors and Options of Management for an Incidental Dural Tear in Biportal Endoscopic Spine Surgery. Asian Spine J. 2020;14(6):790–800. Chen Z, Zhou H, Wang X, Liu Z, Liu W, Luo J. Complications of Unilateral Biportal Endoscopic Spinal Surgery for Lumbar Spinal Stenosis: A Meta-Analysis and Systematic Review. World Neurosurg. 2023;170:e371–e9. Park H-J, Kim S-K, Lee S-c, Kim W, Han S, Kang S-S. Dural Tears in Percutaneous Biportal Endoscopic Spine Surgery: Anatomical Location and Management. World Neurosurg. 2020;136:e578–e85. Ahn JS, Lee HJ, Choi DJ, Lee KY, Hwang SJ. Extraforaminal approach of biportal endoscopic spinal surgery: a new endoscopic technique for transforaminal decompression and discectomy. J Neurosurg Spine. 2018;28(5):492–8. Mobbs RJ, Phan K, Malham G, Seex K, Rao PJ. Lumbar interbody fusion: techniques, indications and comparison of interbody fusion options including PLIF, TLIF, MI-TLIF, OLIF/ATP, LLIF and ALIF. J Spine Surg. 2015;1(1):2–18. Soliman HM. Irrigation endoscopic decompressive laminotomy. A new endoscopic approach for spinal stenosis decompression. The spine journal: official journal of the North American Spine Society. 2015;15(10):2282–9. Musluman AM, Cansever T, Yilmaz A, Cavusoglu H, Yuce I, Aydin Y. Midterm outcome after a microsurgical unilateral approach for bilateral decompression of lumbar degenerative spondylolisthesis. J Neurosurg Spine. 2012;16(1):68–76. Zheng B, Shaaya E, Feler J, Leary OP, Hagan MJ, Bajaj A, et al. Endoscopic Techniques for Lumbar Interbody Fusion: Principles and Context. Biomed Res Int. 2022;2022:4979231. Itamoto K, Itoh H, Sunahara H, Horikirizono H, Nemoto Y, Tani K, et al. Comparison of surgical invasiveness between micro-endoscopic discectomy/microscopic discectomy and conventional hemilaminectomy in dogs. J Vet Med Sci. 2023;85(6):617–24. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3892549","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":269604137,"identity":"0b4115ec-67e9-4950-afa0-7549ef8aad9a","order_by":0,"name":"Junjie Wu","email":"","orcid":"","institution":"The First Affiliated Hospital of Chongqing Medical University","correspondingAuthor":false,"prefix":"","firstName":"Junjie","middleName":"","lastName":"Wu","suffix":""},{"id":269604138,"identity":"33bae14c-447c-4c38-b7dd-313a300a9301","order_by":1,"name":"Bailong Tao","email":"","orcid":"","institution":"The First Affiliated Hospital of Chongqing Medical University","correspondingAuthor":false,"prefix":"","firstName":"Bailong","middleName":"","lastName":"Tao","suffix":""},{"id":269604139,"identity":"8463573f-7826-41ca-8aeb-f60479f3140f","order_by":2,"name":"Kai Li","email":"","orcid":"","institution":"The Third Affiliated Hospital of Chongqing Medical University","correspondingAuthor":false,"prefix":"","firstName":"Kai","middleName":"","lastName":"Li","suffix":""},{"id":269604140,"identity":"391ec082-ef87-4b45-832e-7e82be6d619c","order_by":3,"name":"Minghuang Cheng","email":"","orcid":"","institution":"The First Affiliated Hospital of Chongqing Medical University","correspondingAuthor":false,"prefix":"","firstName":"Minghuang","middleName":"","lastName":"Cheng","suffix":""},{"id":269604141,"identity":"59eaa0ce-597a-4310-a10d-ea975dcc85b8","order_by":4,"name":"Xiaohan Pan","email":"","orcid":"","institution":"The First Affiliated Hospital of Chongqing Medical University","correspondingAuthor":false,"prefix":"","firstName":"Xiaohan","middleName":"","lastName":"Pan","suffix":""},{"id":269604142,"identity":"e69107dc-7721-4183-8d9a-72fe9d9a6d40","order_by":5,"name":"Xiaojun Zhang","email":"","orcid":"","institution":"The First Affiliated Hospital of Chongqing Medical University","correspondingAuthor":false,"prefix":"","firstName":"Xiaojun","middleName":"","lastName":"Zhang","suffix":""},{"id":269604143,"identity":"1bac8198-40d2-40e4-a430-42779220b83f","order_by":6,"name":"Wei Jiang","email":"","orcid":"","institution":"The First Affiliated Hospital of Chongqing Medical University","correspondingAuthor":false,"prefix":"","firstName":"Wei","middleName":"","lastName":"Jiang","suffix":""},{"id":269604144,"identity":"cefe2156-0823-4313-9524-e9dbb78ed884","order_by":7,"name":"Jie Hao","email":"data:image/png;base64,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","orcid":"","institution":"The First Affiliated Hospital of Chongqing Medical University","correspondingAuthor":true,"prefix":"","firstName":"Jie","middleName":"","lastName":"Hao","suffix":""}],"badges":[],"createdAt":"2024-01-24 01:59:12","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-3892549/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-3892549/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":55744722,"identity":"fde99687-3b7c-483c-8413-83843147bdfe","added_by":"auto","created_at":"2024-05-02 14:11:40","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":484216,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3892549/v1/39f9bcdf-8e2a-47b8-ac18-de09741db7fa.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Title：Percutaneous endoscopic interlaminar discectomy versus unilateral biportal endoscopy in the treatment of L5/S1 degeneration disease: a randomized controlled trial","fulltext":[{"header":"Background","content":"\u003cp\u003eIn recent years, with the changes in people's lifestyle and work style\u003csup\u003e1\u003c/sup\u003e, the incidence of lumbar degenerative disease (LDD) increases year by year, and the onset age decreases year by year. LDD has become the most common disease causing lumbar and leg pain in the world, seriously affecting people's quality of life\u003csup\u003e2\u003c/sup\u003e. The main disease categories of LDD include lumbar disc herniation, lumbar spinal stenosis, and lumbar spondylolisthesis, causing symptoms such as back and leg pain, lower limb numbness, weakness, limited movement of the lumbar spine, and intermittent claudication.Currently,surgery is widely regarded as an effective treatment for LDD\u003csup\u003e3\u003c/sup\u003e.It has been shown to greatly alleviate the aforementioned symptoms,enhance patients' quality of life,and facilitate the restoration of neurological function more effectively than conservative treatments.Minimally invasive surgery,in comparison to traditional surgical methods,not only preserves the stability of the posterior column structure but also boasts qualities\u003csup\u003e4\u003c/sup\u003e like smaller incisions,reduced local pain in the surgical area,minimal blood loss,shorter hospitalization stay period,and quicker postoperative recovery\u003csup\u003e5\u003c/sup\u003e. With the innovation and development of full endoscopic systems\u003csup\u003e6\u0026ndash;7\u003c/sup\u003e, spinal endoscopy technology has developed into a safe, effective\u003csup\u003e8\u003c/sup\u003e and efficient\u003csup\u003e9\u003c/sup\u003e alternative to minimally invasive spinal surgery, making it possible for orthopedic surgeons to perform precise decompression surgery through the selection of different approaches\u003csup\u003e10\u003c/sup\u003e. At present, the main minimally invasive endoscopic techniques for the treatment of LDD\u003csup\u003e11\u003c/sup\u003e include percutaneous single-channel interlaminar spinal endoscopy discectomy (PEID) and transforaminal percutaneous endoscopic lumber discectomy,TF-PELD) and unilateral biportal endoscopy (UBE)\u003csup\u003e12\u003c/sup\u003e have been demonstrated in many clinical studies and meta-analyses to be effective and safe\u003csup\u003e13\u0026ndash;17\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eDue to the similarity of surgical approaches between PEID and UBE, they have been widely compared by global scholars\u003csup\u003e18\u0026ndash;19\u003c/sup\u003e, but few have further classified LDD\u003csup\u003e20\u003c/sup\u003e, so as to compare the influence of the two approaches on perioperative period and prognosis. According to research reports, indications for lumbar total endoscopic surgery include lumbar disc herniation (① central ② paramedian ③ foraminal ④ extraforaminal ⑤ Migrated disc) and lumbar spinal stenosis (① lateral recess stenosis ② central canal stenosis ③ ossification of ligamentum luteum ④ foraminal stenosis)\u003csup\u003e10\u003c/sup\u003e.Based on the classification of LDD, the purpose of this paper is to compare the perioperative conditions, long-term and short-term effects and complications of the treatment of LDD by PEID technology and UBE technology, as well as the differences in the relief degree of LDD related symptoms between the two endoscopic surgery methods, so as to select the appropriate endoscopic surgery methods for different patients. It serves as the foundation for creating a personalized treatment plan.\u003c/p\u003e"},{"header":"Materials and methods","content":"\u003cp\u003eIn this study,data from 79 patients with lumbar disc degeneration(LDD) who received treatment at the Spinal Surgery Department of the First Affiliated Hospital of Chongqing Medical University between September 2020 and May 2023 were retrospectively analyzed.Based on the preoperative MRI results\u003csup\u003e21\u003c/sup\u003e,the participants were categorized into two groups,namely Group A and Group B.44 cases of central L5/S1 prominence in group A were treated with PEID technique. UBE technique was used in 35 cases of L5/S1 central duct stenosis in group B. The Ethics Committee of the First Affiliated Hospital of Chongqing Medical University approved this study,and informed consent was obtained from all 79 enrolled patients.All of these procedures and data records were performed by the same orthopedic surgeon who is proficient in both techniques.\u003c/p\u003e \u003cp\u003eThe inclusion and exclusion of both groups were based on the following criteria. Inclusion criteria were :(\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e) Lumbar degenerative diseases with L5-S1 lesions (L5/S1 central herniation or central duct stenosis) were clearly diagnosed before surgery; (\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e) The surgical treatment was PEID or UBE; (\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e) They did not experience significant symptom relief after 3 months of conservative treatment before surgery;(\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e) Complete clinical and radiological data; (\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e) Complete at least 1 year of follow-up. Exclusion criteria were :(\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e) previous spinal surgery; (\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e) Other segmental disc herniation with instability, the lesion instability is not obvious; (\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e) Combined with tuberculosis, infection, tumor; (\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e) Combined with cauda equina syndrome symptoms; (\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e) Receive anticoagulant or antiplatelet drugs within 6 months; (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e) There are other disease factors that affect neurological function,such as traumatic fracture, degenerative spondylolisthesis, degenerative scoliosis, etc.\u003c/p\u003e \u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003eSurgery procedure\u003c/h2\u003e \u003cp\u003eGroup A: PEID group\u003c/p\u003e \u003cp\u003eAfter anesthesia, the patient was placed in a prone position, padded on the patient's abdomen, and the surgical site was routinely disinfected and covered with towels. C-arm fluoroscopy was used to locate the L5-S1 segment and puncture the affected side of the L5-S1 segment by the interlaminar approach at the paraspinal process of about 1-2cm.After the puncture position was determined by fluoroscopic examination, the needle core was pulled out and the guide wire was inserted. A longitudinal skin incision of about 1.0cm was made with the puncture needle as the center. The serial dilator was inserted alongside the guide wire, and the working cannula was positioned to ensure its tip reached the inner boundary of the lower articular process of L5,close to the ligamentum flavum.The section of the lamina of the affected side of L5 was removed from the starting point of the ligamentum flavum, and most of the ligamentum flavum was removed. Intraoperative findings: the protruding nucleus pulposus tissue compressed the S1 nerve root on the affected side, rotated the working cannula again to make the working cannula face outward, blocked the nerve root and dural sac at the tip of the tongue and pushed them inward for protection.The working cannula was then adjusted to provide better access to the nerve root axilla and shoulder,allowing for the removal of the protruding nucleus pulposus.The spinal canal was carefully examined and any free nucleus pulposus was also removed.Further investigation showed that the S1 nerve root/spinal canal on the affected side was decompression completely and relaxation activity was good.Bipolar radiofrequency electrodes were used to perform radiofrequency ablation and annulus fibroplasty. The operation field was completely hemostatic. The foraminal mirror was taken out,followed by the removal of the working cannula,and finally,a small incision was closed. Sterile dressing covers the surgical incision.\u003c/p\u003e \u003cp\u003eGroup B: UBE group\u003c/p\u003e \u003cp\u003eAfter anesthesia, the patient was lying prone on the operating table, with soft cushions placed on the patient's abdomen,Furthermore,the surgical site was disinfected as per the standard procedure and towels were used to cover it.C-arm fluoroscopy was employed in order to determine the location of the L5-S1 segment.A transverse skin incision of about 1.0cm was made from the center of the L5-S1 space along the lines of the inner edge of the pedicle of L5 and S1 on the affected side,respectively,and a special dilator was used to expand the channel successively.\u0026ensp;The cephalic side was used as a mirror observation channel and the caudal side was used as an operation channel. Installed the mirror and connected it to the camera system.The lower margin of the L5 laminae and the upper margin of the S1 laminae on the affected side were first explored to confirm the L5-S1 laminae space again.The RF electrode was used to expose the ligamentum flavum, and the drill was used to remove part of the bone of the affected lamina of L5 to the stop of ligamentum flavum, inward to the base of the spinous process, and outward to the internal margin of the articular process. The same was done to the bone of the upper margin of the S1 lamina to the stop of ligamentum flavum. Floated and removed part of the ligamentum flavum. During the operation, the S1 nerve root and dural sac on the affected side were exposed by the protruding nucleus pulposus tissue under top pressure, the nerve peel was separated to reveal the nerve root, and the protruding nucleus pulposus was removed by pulling the hook to the medial side. The spinal canal was carefully investigated and the S1 nerve root and dural sac on the affected side were released. Further investigation showed that the S1 nerve root/spinal canal on the affected side was decompression completely and relaxation activity was good. Radiofrequency ablation and annulus fibroplasty were performed with bipolar radiofrequency electrodes, and the operation field was completely hemostatic. The spine endoscope was removed, then the working cannula was removed, a negative pressure drainage tube was placed into the incision, and a small incision was sutured. Sterile dressing covers the surgical incision.\u003c/p\u003e \u003cp\u003e \u003cstrong\u003ePrecautions\u003c/strong\u003e \u003cp\u003eClose monitoring of intraoperative vital signs and ensuring proper air\u003c/p\u003e \u003c/p\u003e \u003cp\u003eway protection should be prioritized.\u003c/p\u003e \u003cp\u003e \u003cstrong\u003eSurgical outcome\u003c/strong\u003e \u003cp\u003eAll the patients had successful operation, good anesthetic effect and satisfactory hemostatic effect. After surgery, the patient returned safely to the ward.\u003c/p\u003e \u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec4\" class=\"Section2\"\u003e \u003ch2\u003ePostoperative management\u003c/h2\u003e \u003cp\u003e(\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e) Anti-infection, analgesia, dehydration and detumescence, neuronutrition and other treatments were given after surgery; Blood routine and blood biochemistry were reviewed the first day after surgery.\u003c/p\u003e \u003cp\u003e(\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e) Guide patients to perform axial rotation and functional exercises of lower limbs during bed rest to prevent venous thrombosis of lower limbs, bedsores, hypostatic pneumonia and other long-term bed related complications .\u003c/p\u003e \u003cp\u003e(\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e) The drainage flow of patients treated with UBE technology was recorded every day, and the drainage tube was removed only when the drainage flow was less than 30ml/d.\u003c/p\u003e \u003cp\u003e(\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e) After the drainage tube was removed, lumbar X-ray anterior-lateral radiographs were reviewed on the same day; You can walk with a lumbar brace.\u003c/p\u003e \u003cp\u003e(\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e) The patient was instructed to wear the lumbar spine brace for at least 3 months, and lumbar MRI was reviewed 1 month after surgery.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec5\" class=\"Section2\"\u003e \u003ch2\u003eClinical indicator\u003c/h2\u003e \u003cp\u003eThe fundamental information pertaining to admission and operation was documented,which encompassed age,gender,time of operation,intraoperative blood loss,duration of stay, and rate of complications.The degree of lumbar and leg pain before surgery, as well as 1 day,1 month,3 months,6 months,and 12 months after surgery, was assessed using the Visual Analogue Scale(VAS).Dysfunction index(ODI) was used to evaluate the degree of limited activity before surgery,1 day,1 month,3 months,6 months and 12 months after surgery.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec6\" class=\"Section2\"\u003e \u003ch2\u003eStatistical analysis\u003c/h2\u003e \u003cp\u003eSPSS 25.0 software was used for inter-group and intra-group comparison. Counting data were tested by chi-square test.In the measurement data, independent sample t test was used for component comparison.The paired sample t-test was utilized for the intra-group comparison with matching normal distribution,while the non-parametric test was employed for the non-matching distribution. P\u0026thinsp;\u0026lt;\u0026thinsp;0.05 was considered statistically significant.\u003c/p\u003e \u003c/div\u003e"},{"header":"Results","content":"\u003cdiv id=\"Sec8\" class=\"Section2\"\u003e\n \u003ch2\u003ePerioperative clinical data\u003c/h2\u003e\n \u003cp\u003eA total of 79 patients were eligible for the study based on inclusion and exclusion criteria. Based on the distinct surgical approach and LDD classification,the patients were categorized into two groups Group A and Group B.Group A consisted of 44 patients who underwent treatment for central/paracentral disc herniation of L5/S1 using the PEID technique. Group B included 35 patients with L5/S1 central duct stenosis treated with the UBE technique.There was no significant difference in age(t test)and gender(Chi-square test)between the two groups(P\u0026thinsp;\u0026gt;\u0026thinsp;0.05). Both groups completed the operation successfully. All incisions were Grade A healing.There was no significant difference in hospitalization stay period between the two groups(p\u0026thinsp;\u0026gt;\u0026thinsp;0.05).The duration of the operation was significantly longer in the Group B compared to the Group A(p\u0026thinsp;\u0026lt;\u0026thinsp;0.05).The Group B had significantly higher intraoperative bleeding compared to the Group A,and this difference was found to be statistically significant(p\u0026thinsp;\u0026lt;\u0026thinsp;0.05).\u0026ensp;The analysis findings are presented in Table \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e.\u003c/p\u003e\n \u003cp\u003e\u003cstrong\u003eTable 1\u003c/strong\u003e\u0026nbsp; Perioperative clinical data of patients with L5/S1 intervertebral disc degeneration\u003c/p\u003e\n \u003cp\u003e\u003cimg 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AREAANAtAREAANAtAREAANAtAREAANAtAREAANAtAREAANAtAREAANAtAREAANAtAREAANAtAREAANAtAREAANAtAREAANAtAREAANAtAREAANAtAREAANAtAREAANAtAREAANAtAREAANAtAREAANAtAREAANCt7U87Zs/Xtr29PXsGAACwv/YQqqxsTwERAADAUWbKHAAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEQAA0C0BEXCsbG9vz54Bm0o+BTbJsQ6IUuC+f/9+tnY47t+/v3Xz5s3ZGgAAsMm+S0CUgCHByps3b2Zb9l8Ckxs3bmydOnVqtuVw/Prrr1sPHz6crcHxlc6G5OMzZ87MtnwteTD787jI06dPh+NqmepQWPVc66prTqn7WtbBUZ9DLZcuXZrt+Szl3KL9cJCqvk16bq2S71rJ5zluqpOx0vhBpO15919lQrssKh/qPLW07Y92e7scZBuFo2OcdpZ1tI+PH6fdSF7JvnEaG6fr/a7zmO+7BEQJGBKs/PHHH7Mt++/Ro0dbv/zyy2zt8CQAu3jx4mQGgOMkhX7S+pRUGLdv3567vySfXLlyZevTp09flgcPHsz2frbsXG3lkWXetlZVOq9fv55t+Voaf3/++edQTi2TzyHnyb2/e/du68WLF1/yf+793LlzX/Znefv2rUqOQ5HG1suXL7dOnz492/LZKvmu5NjklcePH8+2fC0Nu7t3727du3dvtmVamx+zzNtWkneyLfX4+P5LyoT2Pdy6dWu252vJb2l31HFPnjwZ8mVpz1H7c82zZ8/OjqBX47STdD4vPUbqg6TdNj1dvnx5tvezee3DXCtt1/a189I0++/QA6IkhBRiV69enRxJqai5XSqCroJ5vH0siTENk59++mlYTwLN0sp1qlGy7LztvrYhk3NmvXrO6nXnz5+fW3nAcVAF+rVr14bHseSNNCqWuXPnztygpCw7V1t5ZJm3rZVKZmp7SdAyr4E49vz58y8Np+oQ+fDhw7Befvjhh9mzz8EWHIbkz6m6aJV8V9KYS15p03Ar6T/LMm1+rLw3ta0kL2XbuDG5G69evfoqYMs506id1zDN53P9+vXZGj1LgNLWPxWgTKWdtD3Trl2WH9IZMVW/pOMvHRh8H4ceEKVwTsCQBsS4QEpwkYZIWzgmIebYBBtJRAl0si+FedvD0/r777+Hc9d0uXHwlUSbXtxMb1t23jRe2n1JsHl9yXreU/ZXo+jHH38c3gccR0n/8wr0qE6DZQ2Z6rhIo63tdGjz16rn2hQpT6psiZRBGWWqHsUEdykb9Ppx0JLWLly48M0oxyr57qhIXqv7X9TRkHyYhm0rx487LiJtknw+8iiRtHDixInZ2mcpz6fSTrU923w1TpfpjE9wXu3TUh3qybPt6zk8hxoQpcBtGwvpgWl7r/75558hMZS2pzXT69rvBE0FVGWcUMfHPnv2bDh3zrXsvGm8tPvi33//HR4jrx1XOMk8yURwHKWhNVWgR/J4OglWHV2J6lDIkvxUZcBuzvW9VOVV0+Pazyb3n88r+9MxoweQg5bGVdLaorwzL98dFTXKW0uksTmlPofKp1nSFpmS0aF2NAnGFgXfafuN02XqzEi7clmHWOqHem3aqfPSNPvvUAOiNhCJn3/+eSiUKjI+efLkV42F7MtoS0kB3xZoi4KOcYJtg6/0FLVTfRadN/fW7lvHUexxg0WWFeiLgqV52qk4Gc2t/Lebc0VVQoepKrAsKVvaSqzKjezLe0uHSzv1FvZb0uCyKavz8t1h2e98mu8xzQtyIuVWm0+TD9v2RaS+z+dQnbYwJWlpnqSrVtqe1RbMzIp2EGBKW98lHy+6FvvrUAOiBCIpsCq4qKlp7Y8rpDCq/em1aqfKZL0t0LLMm0ozTkQp4Cr4yjVWOW8ScfX41vZ1rNuQg02XHxpo82hNN83z5K3ksYzq1P5an+pRq/zRjri2Vj1X7V+0HKY0zKr8SeCTTqAKIPOe01AdT9+B/ZJ6K3kyebPSf60nUF+W7w5Kmx/nLXs1bozOU+2A+p5xSd5Ne0DdTUma+vjx42zts6SddOiPLZodlDQXaVO26T3r6fyrDgod6d/PoQVEVQBlaQOP9ADX93vyxcc0FmpfO9xf3wNaJbGMe30iBVwSdiLuFHhllfNWQp2anjclmWfVghmOkuTJNv8mvyat53mmjrb7siQYSB6vACEFfxvQZH8aIaUaJLHsXGV83NSyn1IOpDKrMmPckEsPYL3HlEUJ5Nrypd0P+y113Tj9J48mr9aXvRflu9TVSdPVgNsv43uaWtYxzkMJ+NofQsh7mDcSm0boOPDJ+01e/e2332Zb4PN3ejKNsiRNJT/VVyWSDmtKXG1r01068dLunKofIx3uqVerjfr7778P28OPexyynT/KodgpfIZlbCdASqr4tFNYf3neLjsNoNmRn4ZjxvvzmrE6z3hfzpXtOwlwtuWzReet12TZqUQ+7STYL6+f957ymhwLx13yTvLEPMkHbR5Ofhkf3+a7RflmfK69aPN1u5Tc43hf5fUqL6bKiCzj95DXtfsXfV5wEJLmkm5bbZps02zqt2yrem6qfsxS6T+vHe9blI9XVfX4eKn3Mc5X47Kh3TbOo1P1du55P+6b42ecxlvJW216qvxTyzhdtrK/bY+O0/xUOuXgbOefnQ9+IyTSTk9VTWdLr+pOYhtGldYdwh6fK9Kzm16kg37LmZaQX9LzKzUAALDZDv1ntxdJ4NP+vGHNcV43GIoMM+b7Dq1V/6PFvUgQl2F3X8oEAIDNt1EjRJnDWz+0UHYzOhRTo0uZU/zkyZO5P8SwHzJ3ND8fvujnTgEAgM2wUQERAADAYdqoKXMAAACHSUAEAAB0S0AEAAB0S0AEAAB0S0AEAAB0S0AEAAB0S0AEAAB0S0AEAAB0S0AEAAB0S0AEAAB0S0AEAAB0S0AEAAB0S0AEAAB0S0AEAAB0S0AEAAB0S0AEAAB0S0AEAAB0S0AEAAB0S0AEAAB0S0AEAAB0S0AEAAB0a/vTjtnztW1vb8+eAQAA7K89hCor21NABAAAcJSZMgcAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHRLQAQAAHTr2AdEly5d2rp///5sDQAA4D/fJSDa3t7+arl58+ZsDwAAbKa0Wds27Pv372d75nv69Olke7c9TzrwW1lv92d58+bNbC/77VADovwh8we9d+/e1qdPn74sSUxJLAAAsIky4+jhw4df2q9pz54+fXq2d74rV65sXbx4cbb2WYKjJ0+efDnXixcvvpnRNG4vnz17draH/XaoAdG1a9eGP+6tW7dmWz57/vz51uXLl2drnxNcGxG30XfWK9LOcubMmdmez9p942g7KiirpQ3Ecnz7+lWifgAAjr9Hjx4NQUyp9uyiTv0EPmn7njp1arblswcPHnzV9r1x48bWP//8M1vjsB1aQJRA5N27d1u//vrrbMu0JKrbt29/iYaT8C5cuDDb+9mdO3e+7I+KqBPAJAp//fr1sC8BWCLukv3nzp37sj/3k+PbwCfr2Z7948QLAECf0j48ceLEbO2zjBB9+PBhtva1tGlfvnz5zUDAlLRFT548OVv7LO3h6qT39ZKDdejfIaogox2JyVLR9ePHj4dIuiR6TgJs503mmHL9+vUvEfWzZ8+GIckaUsxr2yHK8f7cS9azvUxF8QAAMDaeqdRKJ3vbZp0nbeB04LeBU2ZPVed/2sGZqudHwg7OoQdENRqTYKX+0OP5l21EnGWZdoRnWTCTBNeeux1BAgCAVb19+3b27GsZ0ck0uGXf+0kbtmY3zZO2bc716tWr2Rb226EFRJUg2tGYecZfIsuy6hfJ2uBoSkaExudeZSgTAIB+pQP/48ePs7XPMnrz888/z9b+k6lyGdWpDvg8r/WSNmvOma+HrNLONYPp4BzqCFH+4Bn9WTTkl+/95JjdSILMiE9Nr8t12hGgfH+p3Q8AAKvId9rzPfaSdmYCmgpmMn2uvuuTkaO28z0jPFnyPNIWzWszMtT+uEJkX/udoawnmLp69epsC/vtUAOi+j7Q1JS4Sgx5zAhRu7+OWSYJMq/NDyfkNfluURJfSWSdhFf7axEgAQCwSH4ZLkFPtR/Tnp03ZW6Zu3fvDo/jNmlGjdKezQhTbasfBFt1thTr296JVD+HqgAAAJ059B9VAAAA2BQCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCIgAAoFsCon329OnTrTNnzszWgHUk77x582a2dni2t7eH5dKlS7Mtn+Ve2vx8//79rZs3b87WoE/JJ6nrDlvyYvLpuI59//79sL3k3sZ5GWCR7gOiNHiqMTSlCtp5+4H/VF7JMhVctPvHgUV1Jpw9e3a25dvXtOdst9cyT5uPs7TnyX3cu3dv69OnT1tv3779KiA7d+7c1suXL2drW1u//vrr1sOHD2drcDRVYJFlHFzEov3JH8knly9fHtbTSVDH1pJtkTw93pdl6pqtOq6Vc164cGHIp3l9G5Bl++vXr2drW8O9vXjxYsj3AKs4VgFRGjkpRNsGzaouXrz4pRBv/f7778O+ULjCfAksnjx5MjRYsqRBUnkqeSfBRbs/gUXbqHn8+PHW+fPnZ2ufG155zbt377685vnz57O9n6URVPuyzHP69OkvQU+WNOjae/vxxx+H52lYffz4cXhe7+fUqVPDeuR5yoP2vuEoSbq/fv36V3mm7ZxIPZqAo/bneduB8Mcffwz5pJU8UcdnuXXr1rA9gUm7PUuOzfWn5N5Sh7fBTfnnn3+2Tp48OTxPOfHhw4fheb2ftiMlbty4sfXs2bPZGsBixyYgSqGYBlikEbWua9eubT169Gi29p802u7cuTNb+08FX1naymJKHZdl3CsOx8WDBw++9BpHGiRpxMTff/89BCXt/gQoCYJK8u/PP/88W9vaunv37jcByW5UB0k10iLnrvye81fjKsHRiRMnhoAnz9v7LWmMtfcNR0nyQZsXEkxUZ18ekw+Tl0vqv3a0JSOmv/zyy/B8XcmLOVdGWqfkvhI0TUkwVOVJHtOJkfMlH7fvp+Qep+p0gCnHJiCqgnK30vBJT3Q7upQgK71ZP/zww2zLZwlqEkBVj1cK+Hk9xulda3umU5noXaYHaUBVj26CjHH+SoMmIzVR29te3uSrNMbaDoX29ZHOj9o3L19V/m331/3Eb7/9tnX79u3hHAmOcvyVK1e+GY0q7X3DUZe6szod/v333+Gx7YSo/JN9ydPJNz/99NOwrSSvVj5cNB0uHRHpKNlNJ0eCnnRQ5hq5j9TZ4ymtrTaPAyy100g/Nk6fPp2upU+vX7+ebVkux9bHsBO4fNoJgIbnkfNl/06hOhyTxyl5TV4bT548GV4X7bnL+BpwHCUfTKX9bGuXyitTx2c920u9fkq9fl7er/3jZUryZ45v77c971S+hqOo0nLVbfPSduWB8fFTkqen6rhVXlvm3UdrJ7Aa8mibt9vyYlm9DdA6Vt8hSq/tznv6Zi7xqjKMX1MDqjd53rmqNyxLXrNIe2x6ouE4S/7JCMtOo2a25bOaDlPLTmPmq97knYbU7Nl/0stbappNzj+W3uK8/q+//ppt+Vr2t9feaThNXi+jwum9zvHJqzk27yMjwmNT9wFHSX2vb9GIzVQ6X3R8RoGm6sR892gnUNrV6NBY6ufcV8qUjCLvBD3DknJnrEa9ABbp/lfmWimoU2DnhxTyHYF5X/wcT4PLaxap42qZNxUHjro0UhJopJG1rGMi8/vbH1FIg6aV89QPHKyqfhxhmeTv8RfDc++5p3x/ot5HjKfMlv1o2MH3kg661GMJ/kul9TYIqoCizc/t/injzoYcP+/7uLvRTmlNuZG8OC8/zsu/AC0B0Uh6glNwp4dr6ouapRpeKejnjRClAknFkF5nOO7y/Z6k94yotI2sKfkeXhoylcfakaCSgKVtQNUvPqbhkzzVfico6zlfXTfrafBNyb7k2Xx3qJXr1Y8l5Bo5X/L3uIc5Qdq4wQdHRdJ08kY6LcZ1XNJ90nbyWqnv/cRUcDH+zlCClXFnYuXdcSdJ8nDuZVmA1cqPGOXeS+43Zc/4HFPfhwKY61PnpuYq7xSww/zkstMw+moucr2mlprLHDsF9ZfvRZT22Cx1LBwnOw2eb9J6luSbykPtMpZtyVut5KU6vs1Xy86XPNZuGx9bebm0ebjUObK095Xtea9wFCWtt3lhKo2328dpPfkw9VwZn2+cjyqvtq8p2ZZ9lR/bPNcuJfvbujnqHFnaa+T5uC4GmGc7/+wUJADfVXp+M4Vu0cjsJjgq9wkHof7riPanuTfRUblPYDOYMgdshExXffXq1WxtM9UU2Xn/jwocd1evXp37U9ebJFPfc68AqxAQARsh3/9JsDH+v4Y2Sf7n+xu7/H9U4Dio7wG13+HbNLm3qe8sAcxjyhwAANAtI0QAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQAAEC3BEQb4P3791vb29vDI/To5s2bW/fv35+tHZ5Lly4NeS/LWJsn37x5s3XmzJnhOfQqeTR59bDlmpVPx/Vk8mXyZ1RdCrCu7gOiFKRV0NaSRhKwnjSWkn/GgU1tb5f2mDRiHj58uHXr1q3Zls+NnPb4eZbtLxX4VMMpnj59Ojx++vRp68aNG1/dU45/8uTJ1qlTp4b1s2fPDo/t6+EoSrpPXhgHNrW9XcbH3L59e+u3336brf1nKu+P69Z235Q26MlSeS2PL1++HPLpvXv3tn7//fdhe+Q1169f/5I/k18vXrz4JW8DrOpYBURTjZ5VpbCt5fnz57OtwCqS7yKNkSnZ3uaxNvh59uzZV69LwymNnDr29OnT3zTMItvmXa9Uo+zOnTuzLf/58OHDl4Dnl19+2frnn3+G52lMZfvly5eH9ZJ7+uOPP2ZrcPSko+HPP/8cOgCmJK+1+fTBgwezPZ/zRfZXninp0EigNM6L165d23r37t1wntevXw/HzKubk+fTKVLXTWfEuXPnhn0fP378Mjr7888/fzVqm+dtWRK57uPHj2drAKs5NgFRCtQXL14Mz6sg3Q9tT3U7cpTCOPty3dqf5zVkPz4+2mOzLFLBXZaqDGBTpREzbpis6tWrV1vnz5+frW0N52nPlUCkGkEl+S+9xlOBTis9x7m36kFu/fjjj1/Om+Do5MmTw/qVK1e+agiWNMbSaIOj6u3bt5NpexUJpC5cuDBb+086JhLAjOVa7QhrgqkEN1NSBmT0p6QzIscnCDtx4sRwrsjr65yp56fey08//TS0BcZlBsAixyYgqt7d/ZSgJBVA9VpFgpqS3q9cN/uqB6ztYUuhXEP3eaxjs6Q3barXO2p7HZt7mHcsHAXJC/MC/OxLsDFP8lV6fVtpDO21FziNrjS0ck+PHj0agrDkteTlKT/88MPwqKHFcZU6rfJpllY6IDKS2qr6cDyaOiXnTnAzJUFO8mAr5UQ6KhJMVcdkdVakbm6ntLZq27///js8Aqzi2AREKSQTjMS8Bs0ibSWQ4CONnjTU2vnSaZSNC+3qoaoe6PbamZaQAj1SYbS9WekRn9ewSi902/N99epVPdMcWQk0KrjPEjV6Oi8PtCOk6TluG1zJn8lbU6M+60pAlHvKYxp31QNe1247QDS0OM6Sx9p8mk67tvMiAU0reTedFVOjNGPJsznfvDxb56h8lyX1b8k09rqv6mTMSFAdO+4wXDQaBTDlWH2HqBo3u2koVWGbpS3gU7BWoZveqXW1I1dtIy8VySLpAa9j93MKIHxvd+/e/aqxEzX6UtoGUPJQ8kFkqlw6B1ZphK0j501nR86b+0vHRq6dfDoO2jS06EE65RIEtem/HeFJEJLOiqlRmlYCmOTZZd/Nrfq7ltS9mdbayr2kHs658uMKGSXKsRm9Sh5uVWckwCqOVUB0EFIhtIV0Cu3dqB6sOk87X3pKNcjaBY6LGs0ti0ZdapQ2jaG//vpreD7uLMjz6jnejYz+plEVyeMVoI3vM+ZN+4HjqA142s6AdGqkw6DyYq23o0rJkwlgxqNLyyS4yWsyCtRKPVqzMFIeVF4cT8ONcTAFsIiAaI5UAhnib3/ic6/aimU89a6V6UDppYbjYNxYSQMpP5QQU73LGUlte3vzK3SRY8fT76pxlOeZ8pPXpXE27i1eJI2s3E/dS+7377//Hp63DbnqKR+PZsFxMM6n6SRof41u3DnQ5sMsqS/T0VedhplumryefeN8nry0qBMjHR25dvu6nC/rNQMkz6uDZNxRmXyr4wJYh4BogQzLp9e4esCyjOcqrypTcTJtoM4z9Ws9ZWo+dX3nAjZRpdO217i+f5O0XvuzpNHU/opcGlLVsIlM1WmnjOZ8aVTtRgVIWaLOWwFTGmRpnLX3k+unIZfj2ilBNYo1btzBUZGgJ+k6dVHVR1WnpVMg67Uk37ZTU7OeX5pbVfJttOecGsmJlBXtcQmG2msnv9aU1pKR4yprcm8VKOm4AHZje6ehYS4W8N2kMZSf3V32HYPv7ajcJxyEdB6ks2C308YPy1G5T2CzCIiA7yo9upmOs+lFUXq3M5V1lZ8YhuMoozGZjrbJo6SZTZFfcW1HfQGWERAB392mN2IyZSffqdDrTM9qel07dW2THJXOFWDzCIgAAIBu+VEFAACgWwIiAACgWwIiAACgWwIiAACgWwIiAACgWwIiAACgWwIiAACgWwIiAACgWwIiAACgWwIiAACgWwIiAACgWwIiAACgWwIiAACgWwIiAACgWwIiAACgWwIiAACgWwIiAACgWwIiAACgWwIiAACgWwIiAACgWwIiAACgW9ufdsyer217e3v2DAAAYH/tIVRZ2Z4CIgAAgKPMlDkAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiIAAKBbAiLgyNve3p49AzaRPApsMgHRCp4+fbp15syZ2Rp78ebNm28qxny+ly5dmq19K599jtmLnH+v5wAA4Pg51IAojdL79+/P1j57//790EDO40HKNerae7lmvXYvjevcxzgASKP/5s2bs7X9lfttl71cZz/e/9idO3eG5SBdu3Zt6/Hjx7M19lPS8ziNjfN5a3z8+NjkjXb/fhlfN8H5KpI3c3xbXlQ+qOWg8i7sp0rLtcyrA5el73EenXeedaVeac+7qJ6pzrV2GderUe9Fpyb7pc1Hq6SrRflulXNVvlDPHKxuRog+ffq0devWrdna7p06dWo41+XLl2db9sfbt2+3Hjx4MFvbf69fvx7uO8vDhw8XNlgX2e/3n0rt3bt3W2fPnp1tORi53xcvXuxbxc3XLl68+CV9ZZmX11Kw3759+8tx+dtnvYKTFPjJC7X/xo0bk5VEVSC1zNtW8nd/9OjRl/Peu3dv69y5c7O98yWfTF3/9OnTwznqfHvJU3AYko6vX7/+Jc1mSXk+ZVH6HufRHHfhwoVhX2sqP05ta125cuXLeZ88eTKsLyuz6/gsz58/n239T+435RPshwTdyUuV5vJ8KhAvi/LdqudKPpCGD95GBkTjnty2l2jcK1QNqSSiHJcENd4X2Z792ZbCPvKY46rAbV+7KBJvz92+JktVGjlnu73eQ86bBmAa59leiT+PbYMqx7evH+/L8TnX1P5lUoG9evVqtvb1e2gzY95j9tXfoz6TPG8/2/Y+xvuiPf9ff/012/pZ1scZva6XZerv0F4v5476vNvKM/eRbSXXefbs2WyN76XyX4wbZGl4tSN5v/322xA0jdNUW7lkmbet5DppxJVff/11eFzU2Mq+5NVxR0XyX95DG/QlTyXggk2UNJuycpVOwWXp++XLl1t3794dnkeO2488Gu226nT7999/h8fdyHuJzBCAvUqdkLZbWydkdsu8ztZF+W7Vc6W9k/w3r/OC/bNxAVEaw20PckY2Eh1XYZuCLT1Htb8dWchxaUxlexLQVA9wjk/hHXnMsUloCQTqtdmehtm4gJ9SPWV1zp9//nl4TIWS7VmqpyuS+HNv1aM+1aOVTJTj6/7ymM+kCvdIpjl58uSwP59R9k9lyGXyvtO7V/cabXCVa//zzz/DvqkRrGTWVJD1+rzXfO51L9mfAqH2jxuNCczOnz8/W/scxOS91HvPe6zPNnJv9b6z1Lb8DccBzx9//DGMMJQck/fC/kt6HAepU6qRU4F3js3fKPmy0swPP/wwPEZVAh8/fhwe90s1shZVMskXSc9jHz58+OY9/vjjj1+lU9gkf/7551BXVR7NMtXZFMvSd/aNpx+nvtvvPDpVHkxp31NbB+Z56tGpegt2Y6reqPQ5FbgvynernCttvrSvVunIYO8OPSBKY7dNHG1vcaTB3DZC0lBKQ7cdWUgim5JAowKkSkCrBDWRwKRemwS6bgGfRF4Nu6jGevz000/DY1tYL5LKpu0RyGPO3b7vtgcv18z6VIYcyz3kb5DAMs/TkE0vfMn2cdCyqEIZ9+inwZt7+fvvv4f17G+/HzSuSNte+6ggpt573mObRrLeFg5ptFaQM773XPvq1auzta0hkFr1b8Dq8veoALXSfTvSOFZ/8+T/WNZgaf/++yVpJXlsngTZafitOjX0xIkTs2ewmZKeK48muEn52HayLdKm79SVbQdIloPoDKg6tW0wtlLvteVOjm3Liry+rUfhICxLX+vku/G5qpOfw3HoAVEKqLYQmypIx42LJJJq9KYxlYg5hfCiRles05BKQ3m3BXwSdyqItmGXbXWu3TTo0iPXWqUxvyiAy6hN3UsCzrahl211rzWStY5xD14KgPQylmU9fFPvdZGcv+43hUvJe8rfLUFwPv+8rwpQyzgAY/9lOk3yw5T8bfJ3S5Cc/J9js76o42KVvJhzrSoNpaShNrBuVafBOj3L+907DvutbWzleToa23J6kXH6buvwynvLOgXWyaPpkEhZvU4erI69Kv/z+nl5HPbLsnbZOvmuPde4k52Dt5HfIRoXvkkkbSM5BV0K1zy207vG1glqKlCoAn6dICZBRDuqlQJ5POVtXeMMk4CwzVjran9UYdzrXfdZy7pBw3hkKq9vg5xlI1dT73We8RS/FBitrGeUKaNp+SLjWBrCHLx5+ScBUDuSm7RYf7NK3216qQqiRllLBcSLlimpZNKhMjVVtdToZnUU1HvJY8qbpO1xHkkaTkUHm2id0fF103f1do8bbuP8OLVMSR5Lh8S69VBJB1zK/9RrdZ2qj/N8UecLLFKdu21eqvpqKnBZlO+WnSv1VDp8Kw3nea1zMDYuIEojth2lSOGV3ub6EnRr3LhNIVqJK4VqGjBTiXSq4RXVw5VrrhrEpIGVimJqak1dZ/xF/qkKp5XpPO17yWMyQjv9az9Ub8Xvv/8+27K+NGZzvyWVYz67+jxy/vYLuOPvdY3/hr/88svwXuu95/Md/y3a4DjHtvL6KkjGaWavQSXTxn/D5N82GE0BXh0X+fzHUzLzt6q/6Ti9JG1m2/jv1gbw85axBNNJV1N5r0Z0sz9ptz1Ppb88psc5wVmeV0MwahoqbKJ8tzX1aAUD43o1eaNmXKyTvpNfkt+npp+2eWjeMpbyPuXD1L7cc/JovYfKz6Xq4pQVGVlqr5MOy7QH8nyqTQCrSNpKOmrbTKmvqmM26TFptPLOony37Fypp9o0nO1Z8pwDsvPhHpqdwurTTsE5W/tsp+DNX3d4LDt/9GFbLbWvjq0l5yt17nZ/e86dhPdpp1CcrX19jci+Ws+xOV8dn8dsKznm9evXX563S91Te/563t5Puy/Gn834vdT1Ynw/MX5/rfHrx/La9lp1T3lN1sfG58u9t68fa/eNz5n3WZ9ZaT+72l/vbZwGcmzdb8n28Tlj/BmzP9q/V5bxZzzeNi+9lXb/OJ3vVqW78VLXTvrKeptHS6W5dt/4fNIVmy5ptE2z4zK8LTMXpe9l+X23xmV7LXVfdU9135Vnx8dNmaozYbfmpbtKw21bbFG+i3bfojScfDeuK9lf2/ln5w9x5KW3KL9WZs7w0ZIek4wa7WcyzIhFRijGaSE9NzuFkR5CAAC+2MjvENGPBCenT5/+MqS8Vxmyfvfu3TfT5TKEnesIhgAAaAmI+O4ymtN+b2Qv8n2tBD7j75zkpyv36xoAABwfx2bKHAAAwLqMEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN0SEAEAAN3a/rRj9nxt29vbs2cAAAD7aw+hysr2FBABAAAcZabMAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQAA3RIQAQDAEtvb28PC8SMgAo4dFRZsPvmUo6ICoU+fPg0Lx4+A6IDdv3//S0Z68+bNbOtnT58+3Tpz5sxs7Vt57aVLl2Zr+yvnzfkPQs578+bN2dp6xp9JPrf379/P1gAADodAqB/fJSBKY3kqQNg0ywKWVdy+fXvr9evXQ0Y6e/bsbOtmyfvcz8Aj7/m3336bre3NjRs3tp49ezZbY5Mk/ybdTAXtlaZqyfo8dZ5apoLpKjMWnWddSe/tdVftfKhOjnGHwvh8ey07YK/a9Lgon67agVXnmmdRmbAXOV/OO9VmSD6r+1olz7XHZ5mq92of/ao0sEogNK7DlnU2L0qzq5yr9rG/vktA9PDhw6Gh+8cff8y2HE9V0P7www/D46a6fPnykOFPnTo127J7qWBPnz69L+eKq1evbj169Gi2xqZIA+Xu3btb9+7dm235Twr0K1eufOkIyGPWpxozySPnzp3bevLkyZeKJ+VDBT4VZPzyyy9DupqnKoi2opja1kojsO7x3bt3Wy9evFgacOV+EvBfvHhxtuWzbM/91fmyvH37drYXDl/Sd5uvkr7bxlUaYn/++edQFy9TnQBJ34tcu3btm7zRmsqTU9tKNQ7v3Lkz2/K1lEN5H/Ue83xRMJb9169f/3J8lnFdlc9t0XvgeKt0WOljmXEdlrokdcS8umRRml12rlXzIbtz6AFR/rApbNLQTcOnlcIviaP+6FnyvBpFWcaF3Tiabnu6cq2cr5X1Slx5zPnymnp9VRh5TCMuCTLbx+cp866f7dWAy+O810f7ftv7Hxtfq95HyXupfePr5djaN+8zLPUZ1fHtvhjvy1L3nQr2woULw/OY+oyzrX0vi95zRtXyN8jxbI7nz58Py5R0dKSRVSOieUyen+oA+fvvv4f8kaC8JMh6/Pjx8DyNlVQM7f4pVbnUMm9bK/df95jr5B4/fPgwrM+TtJrKauz3338f7ntTR4Hpz4MHD77KN8mT//zzz2xtawjYc8wqbt26NZmHWqnHUvafP39+tuVbU3lyaltJfsq2qXyVdkGCvPY9JHDKtuwbS72Tui3vZZ7UMy9fvpwbgHF8VXtkKh0ukhksqTsqr6UuSV6rOqy1LM0uO9cq+ZDdO/SAKH/YFJgp4NIQSiHVSuM3hXb+6ImCEx3nuEqkSTj1mhReiabbXtkEWRXUrCLnO3ny5FfXS8JMwkvDp6491du76Pp5f3kvkcd5vcV1TF6b523veCv31F4rxyZgq4K/goq6j1RMtS3HtD326cXL+14kx9e5kkHnnSuZNfsrg6cySW9+q/2M85nm9bmHrNd7XhTw5G/w8ePH2RqbLmkkf+9WCvZKq60TJ04MaaD9+//444+HPrqS6yed/vrrr7Mt36pyZSo4S7rPSGZVqlmm8jF8L1P5cr8k/6TuXDXA2g///vvv8JiypdRsjNrXSmddypU2j44741LHTjVkOf6qvVNpY1Vpr7ZpMJLPpuqwZWl2nXOx/w41IEqB3DY6MnQ9VfhUoVq9Qml8lzTAqxd33BMd6aV99erVbG25NLarx6iCtKnCdMp+Xz8ZIedLwT1WPQd1rRyb9fp+TYKKtlerHYEbvzYNuqwv0vaCJ3ipxmx9NnWuBD9tZq0Ar9W+x59++ml4TAMy6n0sCnjSq7es557NNq8hlnSUPJOGSFVECZgPS12zOhvGlVFJ+l/W4Gun4lTgPxUEwmFLcJ66t8rh/ZY6Ymrk9LDNy78ldUnl0XEHZIKjcX1Ofyp9VN2wG+nUW9WyNLvOudibQw2IqmFeCeDnn38eCulFowNT2mH/cUNrP3qX1xmN2O/rz2s4Rj6ryqRZst5qG5V53lqW6Zap91S9GfU3S/A2np6XXv91LQt42r85R8+iv18aaVUJZUmANE5T68p5VtFeN4268XTSksZS7mtRPmorrhpFWrVzBQ5KgvIa1T8IGTlNfp0aOV1m1Xy6qmUdEG3+zfO0R1L3pD5LcHSYI1xstqoXqk21jnU6cJelWZ3Bh+dQA6JMKWkb9dVo38uPK4wbWkk81ZjaTcN8XYuuvxuLGo4pvCuT1tL2+NU0tnYp+91TXcFXKpHxd0kOYnrbokCRzZKGxjgdJ/0t+m5BK+XEqseWKlMWLcvkRyLmdWak3MoIUZ2r1iuv51HFxaZJvssIfUZvDmrkIzMi2no9+aLWx/VOHbNoWVV1zrXXGM9gaKUOmVcP/vXXX8Nj3UO1TfLc1Ne+VVtqXvqcSlep/9rvUpdlaXadc7H/Di0gSg9MhqiztA329LrW1K511bSwdoQphXF6eiOJr/1+QnqypqZ0zVPfb5hn2fVXkfPXdxOSEXK+nHcs0wxTybTXamWoPw26KeORuFwv67uRL8GPA7NWKt/9lkaqYeOjI9Mok46rYE+6S3qrqbIZbZnXaZB9yRPrTu1p0+O8ZWxcuWX6bntf2V95c3yu5IGUXRVAJYBL3i95XfKC6Td8L8l3SYPpKFt39CZBQNL/uHE2JR1ibd5Ivqg6Yjyi2h43b1lVzp33lx80KakDUxdG7j3voQKacT3YlkvjUeoaTcvz3Yx8cfxU2kiaauuOcboat+Pa+m5Zml12Lg7WoQVE9X2bcQFZjaTd9MKksZGer3aqWNarAMu1UjjX/kTaKahXlfMn8ea1U1Npll1/Fbmf3Fdem2vlfqcaUXkvKaTba2WpjFND/e2+uuecb/w5VAZcV7239jptIzI9GVPfgdqLNJAPY7SP1SVt5W/f9gZXeksaSXqrvJN0l7Q7zvtRjZZaUvin0int/qSDTP3J8/3otc091rmzxLxfzlsmDark5TpXPpe9TJ2FvaoOsnGdkTwVKbeznjyXJc/TeJuSAD/7c66ocx201G/tteq9VL2XPFb3XsfMm/Y2rgcXlUswTwVGZdwOTL2X9al2XCxKs8vO9b3yYS+2d/6wq3fJ0L1kyEyRaBuOaQinhzyNwjRU8+MO+9UYTMWXzC+ZAgBwEA71O0QcfRldGveoJfipKW0ZHUhPfvVC7lWNLAIAwEEwQsTaMtUiQU/JNIT2Ox817WI/frEnw8G5lmkNAAAcBAERAADQLVPmAACAbgmIAACAbgmIAACAbgmIAACAbgmIAACAbgmIAACAbgmIAACAbgmIAACAbgmIAACAbgmIAACAbgmIAACAbgmIAACAbgmIAACAbgmIAACAbgmIAACAbgmIAACAbgmIAACAbgmIAACAbgmIAACAbgmIAACAbgmIAACAbm1/2jF7vrbt7e3ZMwAAgP21h1BlZXsKiAAAAI4yU+YAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAIBuCYgAAGBF29vbw8LxISACjjWVFmw2eZSjogKhT58+DQvHh4CoA5cuXdp6+vTpbO3g5Bq5FgDAcSEQOv4OPSB68+bNl4RVy2E01ufJtc+cOTNb+yyN+oNq2Oe89+/fn61tbb1///5AP4N83m/fvt26fPnybMt6bt68+c3nM0+u8eLFi+E9cbwkzSadtmm3JE23+XksaTvbk5aWWXauqDJkv/NoXTvnH2vvKcsq8n5z7Dhv7+ZcsIp5aarSYi3jND7Od1N5oFRZUMu8umtRftqNKkfmXXfZ/tb4/WYZ3+e8/EtfKn2sGgiN09Yiy9LssnMtqpdZ36EGRPljnzt3buv169dfEte7d++2rly5slF/0OfPnw/LYTh16tTwOew2YFnmjz/+2Lpw4cJsbX0PHjwYAqpV3bhxY+vZs2ezNY6DKogvXrw4PLbSaEj6qPycv38bQOf5n3/+OWxfZtm5yrVr1ybvpbQVSN371LaShlC23blzZ7bla7mHe/fufXVfqagWyTlfvny5dfr06dmWz3ZzLlimGkapW8eSFtNJ1aa55KGSfBe1/8mTJ0M9PSV1+O3bt4d6O8fmeqm/x51gy4KINi9mmbetleu099heN+8x69W2qPsaBzmtNh9mOXv27LC9Oil/+eWXb/Iv/ah0WOljFavWYbEszS47V+WRRXUha9r5oA/NTuHyaacgm639J9vaW8nzncQxPNbS2imMv9q3U7DN9nz6tJNohvVcK/tynqj1LDkmclxty5JjIvvrmBhfbycBzvZ8Gs6f17Xnal/bau8hS913ntd9Zlten2vUcdlXn1H7upLja1+WVq7Zfubrnj/P6/3W59Ae234WkX31OXK85G89TntJA5V2o9JIuy2S5ubli7LKuSr9tulymZxjVVP3PpWHll07r8l5xq/dzblgVUlzy9L7+Jhx3lx0jql8PK9cmFcWTFl2z1Pac8+7r/G2MnXPU8b5leMv6Wo36THG6X1RHliWZlc916ppmeUObYQovS47f9Ctn376abblP7Wt7c1JD9XO/Q3Lzh/8q17UnUJq6CGq/emxal+b9cePHw/70uuT19Z67uHhw4fD8bdu3RrOk/Nl39RISO57fL0cV71qkXP+888/35x/LK/Le9lJvMOxuf6UvD49eDkmx+azqPvfyQzD+6uesfQMpic6++r4+qzmfebrnH9KHZslU+Ta3sATJ04M1+T4qzTyww8/DI+REc/4+PHj8LiqVc6VPJW0mVHLw3T37t0vPXfVQ77oHlI2ZFS2epxb654L9lvS4E6ja7a2tfXbb78NdULqkuTD1Aep76acPHlyOLaVfJr6r6T+Sb1S+fcgjMuLrOfeWrl+HTclea9GAdr6nL5V26bSxqpWqcNai9LsuudifxxaQPTvv/8Oj1OF5NS2NMxLprKk4R1pRCRAaaeYpXDP1LCS9bYxkulvtZ5r5fWrJqpM/0oQ014vFUqCkFY1anL+HL+XRNte7+effx4eawpf3kfuvz7PR48eDfdTfv311y/f46ljxtY5/5S2AZfP+sOHD7O1ryso+pT0s1/acyWIn9dQO0jJKymP0lBMMJN7mCqzIoFOGozzgpx1zgX7pabUVQOvTZ9Jf2kAJkBIfkuZ3tZ3rXTipf6oc2VpA6TUz+n4m9fZt18SwOQ+F+WdcWOzlfquGr7ViblJ0/b5/nYbGI2tUx8uSrOxn3Ur3zr0H1WYaihPRcOt8fYUYPMK5Ck5f3v8uiMY40J3lVGQNkg4CG3AlYZVvbepDLObBtc6AV3bO1gWBVQcb/s5QljnSmMl86fnNdQWSaW2F+nxTqdDVZDpoGlHrFvLgrZ1zgX7JQFKpbmk0dQVNYuhgqXaH1mfpw0msiRAqoZc6qLMIFhXXXcVud8EXctGVqfqpSmpHxNcvXr1arYF/lPpvNpY61qnPlyWZvezbuVbhxYQ1QjN33//PTy2si0N+XkN93HjOsdWIq1lUeGY49NIqWPXjbLHQVyChXXPcZDa91ZL+1l+j9GaecEtx0elsTZ/Vlqbmhq7yLJzpbGSkc+qlNKbXevj9F3HLFpWlUZjrlMjqJHR4RqFbWU9FVbbQVHrCXrWORcclHQqpP6qTq/kpXZGRurS7G+nQs+TdJv0m5kGFWBl9LPNZ1kfT0mr/YuWKQmGcr/j6e0pP8aNydzb+fPnZ2vLzWt/QFTbal76XLc+XJRm1z0X++NQR4gyrziNg/rDRgrRbGunfUV6sUr2pQcnUpinkbFKYd3KqE7kem2UvWy0p6agtddLr+7169dna+uZygR7kfuY9+tY3yMoqQysculDeofbvPv7778P21b5+ydPpWKp8mDRuca90ilLsi/Px9dqj5u3rKryUJv/61cUc93ce95D9md9fJ3qjMn9LzsXHIQEEVlK1YFVJyaNtlPOx/szMjvvOzb5rlzyYTo8s4zTfyTYGndYjo+bWsZyD5kiPrUvvwiXmSJVluQ9pN5O/R15bf1CV/a17yfree3Vq1dnW2C+Sp9TgdGiOqytK2JZml10Lg7Izh/2UO00DlKafbXsFJizvZ9l206D58v+nQJ7tuezncL6y75act7YCZy++eWO9po5106i+uqXY7It+7I9xufI/dXrs+TeSu1r5TztMa32XHUPeV6fQV5X9xFT58/9tvefe61zZmk/r/Gx656/Pb4+9zyW8WeV17XX5+hr01YtbfrO37u2j//27b5aKr0krWS9TU+LztUap+O9aPNku1SerPtsl7rnyhNtHmvlPbT7Fp0Ldiv5YZyuspTx9krbUWm4Xdo0mzQ8zrO1LMuDOaa91m5N3WOW9vrjz6C9bu6/LU/acmZ87Lxrzcvj0GrTVpvmpuqKRWk25p0r2tfV0tbLrG87/+x8kBslUfROwvgyzY7dq56wZfOt98thXw8AAPbi0H9UgcOVaQDjX8Q7SKYeAABwlAiIjrkaZWu/t3BQco2Ls/nkAABwFGzklDkAAIDDYIQIAADoloAIAADoloAIAADoloAIAADoloAIAADoloAIAADoloAIAADoloAIAADoloAIAADoloAIAADoloAIAADoloAIAADoloAIAADoloAIAADoloAIAADoloAIAADoloAIAADoloAIAADoloAIAADoloAIAADoloAIAADoloAIAADo1vanHbPna9ve3p49AwAA2F97CFVWtqeACAAA4CgzZQ4AAOiWgAgAAOiWgAgAAOiWgAgAAOiWgAgAAOjU1tb/B/aOB3EksI8QAAAAAElFTkSuQmCC\"\u003e\u003cbr\u003e\u003c/p\u003e\n \u003cp\u003ePEID Percutaneous endoscopic interlaminar discectomy,UBE Unilateral biportal endoscopy.\u003c/p\u003e\n \u003cp\u003eCounting data were tested by chi-square test. In the measurement data, independent sample t test was used for component comparison.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec9\" class=\"Section2\"\u003e\n \u003ch2\u003eCurative effect evaluation\u003c/h2\u003e\n \u003cdiv id=\"Sec10\" class=\"Section3\"\u003e\n \u003ch2\u003eVAS score of low back pain\u003c/h2\u003e\n \u003cp\u003eThere was no significant difference in preoperative VAS scores of low back pain between the two groups (P\u0026thinsp;\u0026gt;\u0026thinsp;0.05). The VAS scores for postoperative low back pain in both groups were significantly lower than the scores before surgery(P\u0026thinsp;\u0026lt;\u0026thinsp;0.05).In the Group A, the VAS scores for back pain were significantly lower than the Group B at 1 day and 1 month after surgery(P\u0026thinsp;\u0026lt;\u0026thinsp;0.05).However,there was no statistically significant difference in VAS scores for back pain between the two groups at 3 months, 6 months, and 12 months after surgery(P\u0026thinsp;\u0026gt;\u0026thinsp;0.05). Please refer to Table \u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e.\u003c/p\u003e\n \u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec11\" class=\"Section2\"\u003e\n \u003ch2\u003eVAS score for leg pain\u003c/h2\u003e\n \u003cp\u003eThe preoperative VAS score for leg pain in the Group B was significantly lower than that in the Group A (P\u0026thinsp;\u0026lt;\u0026thinsp;0.05).The postoperative leg pain VAS scores of the two groups were significantly lower than the preoperative scores(P\u0026thinsp;\u0026lt;\u0026thinsp;0.05).The VAS scores of leg pain 1 day, 1 month and 3 months after surgery in the Group A were lower than those in the Group B,with statistical significance (P\u0026thinsp;\u0026lt;\u0026thinsp;0.05),while there was no statistical significance in VAS scores of leg pain 6 months and 12 months after surgery between the two groups(P\u0026thinsp;\u0026gt;\u0026thinsp;0.05).The results were also as shown in Table \u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e.\u003c/p\u003e\n \u003cp\u003e\u003cstrong\u003eTable 2\u003c/strong\u003e\u0026nbsp; Comparison of the back pain and leg pain VAS between the two groups at six time-points and Intra-group comparison\u003c/p\u003e\n \u003cp\u003e\u003cimg 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\"\u003e\u003cbr\u003e\u003c/p\u003e\n \u003cdiv class=\"gridtable\"\u003eVAS Visual analogue scale,PEID Percutaneous endoscopic interlaminar discectomy,UBE Unilateral biportal endoscopy.\u003c/div\u003e\n \u003cp\u003eIn the measurement data, independent sample t test was used for component comparison.\u003c/p\u003e\n \u003cp\u003eAssuming normality, ANOVA test was used and in case of non-normality, Kruskal\u0026ndash;Wallis test was used to compare the variables in two groups.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec12\" class=\"Section2\"\u003e\n \u003ch2\u003eODI index\u003c/h2\u003e\n \u003cp\u003eThe preoperative ODI index was significantly lower in the Group A compared to the Group B (P\u0026thinsp;\u0026lt;\u0026thinsp;0.05).The postoperative ODI index of the two groups was lower than the preoperative score, and the difference was statistically significant (P\u0026thinsp;\u0026lt;\u0026thinsp;0.05).The ODI index for dysfunction at 1 day,1 month,3 months and 6 months after surgery was significantly lower in the Group B compared to the Group A (P\u0026thinsp;\u0026lt;\u0026thinsp;0.05).However,there was no statistical significance in ODI index at 12 months after surgery between the two groups (P\u0026thinsp;\u0026gt;\u0026thinsp;0.05).The outcomes of ODI index comparison were as indicated in Table \u003cspan class=\"InternalRef\"\u003e3\u003c/span\u003e.\u003c/p\u003e\n \u003cp\u003e\u003cstrong\u003eTable 3\u0026nbsp;\u003c/strong\u003e Comparison of the ODI between the two groups at six time-points and Intra-group comparison\u003c/p\u003e\n \u003cp\u003e\u003cimg 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\"\u003e\u003cbr\u003e\u003c/p\u003e\n \u003cdiv class=\"gridtable\"\u003eODI Dysfunction index,PEID Percutaneous endoscopic interlaminar discectomy,UBE Unilateral biportal endoscopy.\u003c/div\u003e\n \u003cp\u003eIn the measurement data, independent sample t test was used for component comparison.\u003c/p\u003e\n \u003cp\u003eAssuming normality, ANOVA test was used and in case of non-normality, Kruskal\u0026ndash;Wallis test was used to compare the variables in two groups.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec13\" class=\"Section2\"\u003e\n \u003ch2\u003ePostoperative complication\u003c/h2\u003e\n \u003cp\u003eThere was one instance of cerebrospinal fluid leakage after surgery in the PEID group.In UBE group, there were 2 cases of cerebrospinal fluid leakage after operation,and no serious complications such as nerve and blood vessel injury and wound infection occurred.The incidence of postoperative complications did not differ significantly between the two groups (P\u0026thinsp;\u0026gt;\u0026thinsp;0.05).They all showed improvement after receiving symptomatic treatment and bed rest.\u003c/p\u003e\n\u003c/div\u003e"},{"header":"Discussion","content":"\u003cp\u003eLumbar degenerative disease common in the elderly, but due to changes in life habits and way of working, the onset of degenerative disease gradually younger age, and its main divided into lumbar intervertebral disc protrusion lumbar spinal stenosis and lumbar olisthe,etc., the clinical manifestations of the disease is mainly low back pain or leg pain, numbness, weakness, intermittent claudication, with or without lower limb radiation pain, It seriously affects the quality of life of\u0026ensp;patients, and there is even a risk of cauda equina syndrome or lower limb paralysis as the disease progresses. Non-surgical treatment is usually less effective\u003csup\u003e22\u003c/sup\u003e, and surgical intervention is often required when the disease progresses to advanced stages\u003csup\u003e23\u003c/sup\u003e. In the past few decades, minimally invasive spinal surgery has been widely used, and endoscopic surgery can achieve the same therapeutic results as open surgery\u003csup\u003e24\u003c/sup\u003e,\u0026ensp;but with less damage to the normal spinal structure.\u0026ensp;Relevant studies have shown that open and minimally invasive surgery for degenerative diseases of the lumbar spine leads to significant changes in muscle area, and the development of muscle dysfunction in the back can disrupt the normal function of other spinal areas and may lead to further development of spinal diseases\u003csup\u003e25\u003c/sup\u003e.However, the endoscopic approach has less influence on the muscle groups at the surgical site, such as the paraspinatus muscle,the multifidus muscle and the erector spine muscle, than the open approach\u003csup\u003e13\u003c/sup\u003e.After minimally invasive endoscopic surgery, the postoperative pain was significantly relieved and the incidence of related paravertebral muscle injury was low\u003csup\u003e26\u003c/sup\u003e, suggesting that endoscopic surgery has a good decompression effect. In addition, the endoscopic approach has little damage to the lumbar structure and more facet joints are preserved\u003csup\u003e27\u003c/sup\u003e, which increases the stability of the spine and reduces the risk of spinal instability after decompression resulting in lesions of adjacent segments. Therefore, minimally invasive spinal endoscopy technology has the advantages of low surgical cost, rapid postoperative recovery and obvious improvement of postoperative symptoms\u003csup\u003e28\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003eDue to its special anatomical characteristics, L5/S1 segment is technically advantageous in the treatment of L5/S1 lumbar degenerative changes through posterior interlaminal approach. PEID and UBE are both interlaminal approach surgical paths, and precise decompression of nerve roots and dural sac can be performed by excising the laminae and ligamentum luteum exposed to pressure.\u003c/p\u003e\n\u003cp\u003ePrevious studies have shown that a large amount of invisible blood loss occurs during UBE surgery for lumbar disc herniation or spinal stenosis\u003csup\u003e29\u003c/sup\u003e, and operative time and target level of paracanthospinous muscle thickness are independent risk factors for invisible blood loss in patients with lumbar disorders undergoing UBE surgery\u003csup\u003e30\u003c/sup\u003e. Combined with this study, PEID technology and UBE technology had similar effects on normal spinal soft tissue and structure, and there was no statistical significance in spinal canal sagittal diameter and vertebral space height 3 months after surgery (P\u0026thinsp;\u0026gt;\u0026thinsp;0.05).\u0026ensp;Therefore, the surgical trauma was minimized and the stability of the lumbar spine was maintained to the maximum extent. However, the operation time of the UBE group was longer than that of the PEID group,\u0026ensp;so we believe that the longer operation time of the UBE group increased the hidden blood loss of the operation,resulting in more blood loss in the UBE group than that of the PEID group.\u003c/p\u003e\n\u003cp\u003eClinical efficacy is an important part of surgical technology, which directly affects the decision of the surgeon and the patient. In this study, PEID and UBE showed similar relief of postoperative back and leg pain, but when compared in the UBE group, we found that the UBE technique provided more significant pain relief for central lumbar spinal stenosis than for central disc herniation. Similarly, the results of this study show that both PEID and UBE can effectively alleviate dysfunction,\u0026ensp;and UBE is more advantageous in the relief of dysfunction in central lumbar spinal stenosis.\u0026ensp;There was no significant difference in complications. However, the postoperative pain, function and quality of life of the two groups were significantly improved, suggesting that the clinical efficacy of the two surgical methods was comparable.\u003c/p\u003e\n\u003cp\u003eIn the study, patients in both the PEID and UBE groups successfully completed the procedure. The overall complication rate of UBE surgery for lumbar spinal stenosis was 8.1%\u003csup\u003e29\u0026ndash;30\u003c/sup\u003e.\u0026ensp;Among them, dural tear is the most common complication with an incidence of about 1.5\u0026ndash;9.7%\u003csup\u003e31\u0026ndash;34\u003c/sup\u003e. While most dural tears are small and can be managed conservatively, dural tears larger than 10mm require repair to prevent cerebrospinal fluid leakage and other sequelae. Epidural hematoma is another common complication, one of the reasons may be that high intraoperative water pressure conceals the bleeding points, resulting in intraoperative visual field loss. Therefore, intraoperative irrigation water pressure should be controlled within 25-30mmHg\u003csup\u003e35\u003c/sup\u003e. In this study, no serious complications such as postoperative infection, nerve or vascular injury occurred in the two groups. As both PEID and UBE were minimally invasive endoscopic procedures, the lumbar vertebral structure was not significantly damaged during surgery, and the lumbar spine brace could be worn on the day after surgery to move out of bed. Therefore, none of the 79 patients had long-term bed complications such as lower limb venous thrombosis, bedsore, and hypostatic pneumonia.One case of cerebrospinal fluid leakage caused by postoperative dural tear in PEID group.\u0026ensp;Two cases of postoperative cerebrospinal fluid leakage in UBE group were improved after symptomatic treatment and bed rest.\u0026ensp;Complication rates were similar to those reported in previous studies\u003csup\u003e36\u0026ndash;37\u003c/sup\u003e.\u0026ensp;The original disease recurred in both groups, and the recurrence rate (0%) was lower than that reported in previous studies\u003csup\u003e38\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003eIn summary, both PEID technology and UBE technology can effectively treat LDD, and PEID technology has more advantages in short-term relief of back and leg pain after central protrusion, but UBE technology can effectively improve surgical efficiency in the treatment of central canal stenosis, and has the advantages of significantly improving postoperative pain symptoms and dysfunction\u003csup\u003e39\u0026ndash;40\u003c/sup\u003e. It provides a basis for patients to choose the appropriate treatment plan, and is conducive to ensuring the effect of surgical treatment and prognosis.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eThe emergence of minimally invasive surgery has greatly accelerated the development of the treatment of spine related diseases.Different minimally invasive endoscopic techniques have different indications due to the widespread use of minimally invasive technology.The aim of this study was to examine and contrast the benefits and drawbacks of PEID and UBE for treating lumbar degenerative diseases, in order to formulate a tailored surgical strategy based on the specific condition of each patient. Although only one data set was used, these preliminary results provide some insight into the selection of appropriate surgical protocols based on the clinical typing of lumbar degenerative diseases. By comparing UBE technique with PEID technique, we found that UBE technique is more efficient than PEID technique in the treatment of lumbar spinal stenosis, and has the advantages of wider surgical field of view, fuller operation range and more adequate spinal canal decompression.While previous studies have reported on the long-term clinical safety and efficacy of these two procedures, lumbar degenerative disease classification has not kept track of more effective surgical treatments.The objective of this study is to offer patients a personalized treatment plan grounded on LDD classification.Nevertheless, the study possesses various constraints.Primarily, it was a retrospective study performed at a solitary facility and involved a limited number of participants. Therefore, we select patients treated by the same surgical group to reduce differences in surgical techniques, medical costs, and postoperative management.The data's homogeneity can partially make up for the small sample size deficiency.Additionally, the duration of follow-up in this study was limited.To confirm this finding, it is necessary to conduct larger studies and have a longer follow-up period due to the limited sample size and short follow-up time.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe ethical committee of the First Afliated Hospital of Chongqing Medical University approved this retrospective study for medical research, and informed consent was obtained from all patients included in the study. All methods were carried out in accordance with the Declaration of Helsinki and its relevant guidelines and regulations.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare no conficts of interest.\u003c/p\u003e\n\u003ch4\u003eAvailability of data and materials\u003c/h4\u003e\n\u003cp\u003eThe datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study received no external funding.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors' contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eJunjie Wu designed the study, analysed the data and wrote the manuscript;Jie Hao was responsible for proofreading the manuscript; Bailong Tao, Kai Li, Minghuang Cheng, Xiaohan Pan,Xiaojun Zhang, Wei Jiang wrote the manuscript. All authors reviewed the manuscript. The author(s) read and approved the final manuscript.\u003c/p\u003e\n\u003ch4\u003eAcknowledgements\u003c/h4\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003ch4\u003eAuthors' information\u003c/h4\u003e\n\u003cp\u003e\u003csup\u003e1\u003c/sup\u003eDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China\u003c/p\u003e\n\u003cp\u003e\u003csup\u003e2\u003c/sup\u003e Orthopedic Laboratory of Chongqing Medical University, Chongqing, China\u003c/p\u003e\n\u003cp\u003e\u003csup\u003e3\u003c/sup\u003eLaboratory Research Center,The First Affiliated Hospital of Chongqing Medical University, Chongqing, China\u003c/p\u003e\n\u003cp\u003e\u003csup\u003e4\u003c/sup\u003eDepartment of Orthopedics, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eHoffeld K, Lenz M, Egenolf P, Weber M, Heck V, Eysel P, et al. 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Irrigation endoscopic decompressive laminotomy. A new endoscopic approach for spinal stenosis decompression. The spine journal: official journal of the North American Spine Society. 2015;15(10):2282\u0026ndash;9.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eMusluman AM, Cansever T, Yilmaz A, Cavusoglu H, Yuce I, Aydin Y. Midterm outcome after a microsurgical unilateral approach for bilateral decompression of lumbar degenerative spondylolisthesis. J Neurosurg Spine. 2012;16(1):68\u0026ndash;76.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eZheng B, Shaaya E, Feler J, Leary OP, Hagan MJ, Bajaj A, et al. Endoscopic Techniques for Lumbar Interbody Fusion: Principles and Context. Biomed Res Int. 2022;2022:4979231.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eItamoto K, Itoh H, Sunahara H, Horikirizono H, Nemoto Y, Tani K, et al. Comparison of surgical invasiveness between micro-endoscopic discectomy/microscopic discectomy and conventional hemilaminectomy in dogs. J Vet Med Sci. 2023;85(6):617\u0026ndash;24.\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Lumber degeneration disease, Percutaneous endoscopic interlaminar discectomy, Unilateral biportal endoscopy","lastPublishedDoi":"10.21203/rs.3.rs-3892549/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3892549/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e Lumbar degenerative disease(LDD)is a prevalent condition that significantly impairs individuals'quality of life due to the presence of lower back and leg pain symptoms. \u003ca href=\"https://view.paperpass.com/report/659b94c22f05aj1n7/htmls/sentence_detail.html\" target=\"https://view.paperpass.com/report/659b94c22f05aj1n7/htmls/right\"\u003eThis retrospective study was designed to compare and analyze the\u003c/a\u003e \u003ca href=\"https://view.paperpass.com/report/659b94c22f05aj1n7/htmls/sentence_detail.html\" target=\"https://view.paperpass.com/report/659b94c22f05aj1n7/htmls/right\"\u003eclinical outcomes of percutaneous endoscopic interlaminar discectomy(PEID)and\u003c/a\u003e \u003ca href=\"https://view.paperpass.com/report/659b94c22f05aj1n7/htmls/sentence_detail.html\" target=\"https://view.paperpass.com/report/659b94c22f05aj1n7/htmls/right\"\u003eunilateral biportal endoscopy(UBE) in the treatment of LDD\u003c/a\u003e.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods: \u003c/strong\u003eA total of 79 L5/S1 LDD patients admitted to the Spinal Surgery Department of the First Affiliated Hospital of Chongqing Medical University from September 2020 to May 2023 were selected and divided into Group A(PEID) and Group B(UBE) according to different surgical methods.Basic data, preoperative and postoperative lumbar and leg pain scores (as measured by the visual analogue Scale [VAS]), and functional recovery (as measured by the Dysfunction Index [ODI] score) were assessed for each group.The statistical analysis of the results from both groups was conducted using SPSS 25.0 software.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e There were significant differences in postoperative lumbar and leg pain scores and functional impairment indexes between the two groups. Lower back pain score 1 day and 1 month after surgery in PEID group was lower than that in UBE group, and leg pain score 1 day, 1 month and 3 months after surgery in PEID group was lower than that in UBE group. The functional impairment index at 1 day, 1 month, 3 months and 6 months after operation in UBE group was lower than that in PEID group, and the difference was statistically significant (P \u0026lt; 0.05).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion: \u003c/strong\u003eThis study suggests that although both approaches are effective in the treatment of L5/S1 degenerative diseases and can relieve back and leg pain and dysfunction, UBE is more advantageous in the treatment of central canal stenosis, and PEID is more effective in the short-term relief of back and leg pain caused by central protrusion. This may provide a basis for patients to make personalized surgical plans.\u003c/p\u003e","manuscriptTitle":"Title：Percutaneous endoscopic interlaminar discectomy versus unilateral biportal endoscopy in the treatment of L5/S1 degeneration disease: a randomized controlled trial","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-01-29 06:36:41","doi":"10.21203/rs.3.rs-3892549/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"08551dea-c7d5-4001-859a-9f2e10b5ede7","owner":[],"postedDate":"January 29th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-05-02T14:02:49+00:00","versionOfRecord":[],"versionCreatedAt":"2024-01-29 06:36:41","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-3892549","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3892549","identity":"rs-3892549","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}