Bone Mineral Density in Patients With Ossification of the Posterior Longitudinal Ligament

Toshikatsu Mamada, Kozo Nakamura, Yuichi Hoshino, Kazuo Saita, Takahide Kurokawa
In: Spine · 1997 · vol. 22(20) , pp. 2388–2392 · doi:10.1097/00007632-199710150-00013 · PMID:9355220 · W2327097876
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Patients with ossification of the posterior longitudinal ligament exhibit higher bone mineral density in peripheral areas, with a less pronounced age-related decline, suggesting systemic factors may be involved.

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This study compared bone mineral density in 45 men with ossification of the posterior longitudinal ligament against 25 healthy controls using dual-energy x-ray absorptiometry. The researchers measured density in areas unaffected by the spinal condition, specifically the ribs and limbs, to assess systemic influences. Results indicated that patients with the condition had significantly higher bone mineral density in these peripheral regions and experienced a slower age-related decline compared to the control group. These findings suggest that systemic factors increasing bone density are involved in the pathogenesis of the disorder and may be activated after middle age. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

STUDY DESIGN: Bone mineral density of individuals with ossification of the posterior longitudinal ligament and that of normal people was determined by dual-energy x-ray absorptiometry. OBJECTIVES: To determine whether bone mineral density in the people with ossification of the posterior longitudinal ligament is higher than that in normal individuals even in body parts other than the spine, and to evaluate the relation between bone mineral density and age in patients with ossification of the posterior longitudinal ligament. SUMMARY OF BACKGROUND DATA: It is unknown whether the bone mineral density of patients with ossification of the posterior longitudinal ligament is greater in body parts other than the spine. If so, it provides a basis for the theory that certain systemic factors are involved in the pathogenesis of ossification of the posterior longitudinal ligament. Because bone mineral density decreases physiologically after middle age, the influence of age must be considered in evaluating bone mineral density. METHODS: In the rib area and upper and lower limb areas, which are not affected by ossification of the spinal ligament, bone mineral density of 45 men with ossification of the posterior longitudinal ligament of the cervical spine was compared with that of 25 men without ossification of the posterior longitudinal ligament (normal group). RESULTS: Bone mineral density was higher in the group with ossification of the posterior longitudinal ligament in each part and significantly higher in the rib and lower limb areas (rib: P < 0.01, lower limb: P < 0.05). The age-related decrease was significantly less in the group with ossification of the posterior longitudinal ligament (rib: P < 0.01, upper limb: P < 0.05, lower limb: P < 0.01). CONCLUSIONS: Systemic factors that increase bone mineral density appear to be involved in the pathogenesis of ossification of the posterior longitudinal ligament, and these factors may be activated after middle age.
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Bone Mineral Density in Patients With Ossification of the Posterior Longitudinal Ligament Minimal Decrease of Bone Mineral Density With Aging - Toshikatsu Mamada - Kozo Nakamura - Yuichi Hoshino - Kazuo Saita - Takahide Kurokawa Study Design. Bone mineral density of individuals with ossification of the posterior longitudinal ligament and that of normal people was determined by dual-energy x-ray absorptiometry. Objectives. To determine whether bone mineral density in the people with ossification of the posterior longitudinal ligament is higher than that in normal individuals even in body parts other than the spine, and to evaluate the relation between bone mineral density and age in patients with ossification of the posterior longitudinal ligament. Summary of Background Data. It is unknown whether the bone mineral density of patients with ossification of the posterior longitudinal ligament is greater in body parts other than the spine. If so, it provides a basis for the theory that certain systemic factors are involved in the pathogenesis of ossification of the posterior longitudinal ligament. Because bone mineral density decreases physiologically after middle age, the influence of age must be considered in evaluating bone mineral density. Methods. In the rib area and upper and lower limb areas, which are not affected by ossification of the spinal ligament, bone mineral density of 45 men with ossification of the posterior longitudinal ligament of the cervical spine was compared with that of 25 men without ossification of the posterior longitudinal ligament (normal group). Results. Bone mineral density was higher in the group with ossification of the posterior longitudinal ligament in each part and significantly higher in the rib and lower limb areas (rib: P < 0.01, lower limb: P < 0.05). The age-related decrease was significantly less in the group with ossification of the posterior longitudinal ligament (rib: P < 0.01, upper limb: P < 0.05, lower limb: P < 0.01). Conclusions. Systemic factors that increase bone mineral density appear to be involved in the pathogenesis of ossification of the posterior longitudinal ligament, and these factors may be activated after middle age.

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