The Clinical Analysis of 46 Cases of Ovarian Clear Cell Carcinoma

Objective: To study the clinical characteristics and the prognosis of ovarian clear cell carcinoma(OCCC).Methods: Forty-six patients with the clear cell carcinoma of ovary and 43 patients with the serous adenocarcinoma of ovary admitted in TianJin Oncology Hospital from 1995 to 2005 were analyzed retrospectively.The clinical symptoms,endometriosis,serum CA125 level,5-year survival rates,chemotherapy effective rates and prognosis were compared.Results: The percentages of I-II stage patients in the clear cell carcinoma of ovary and the serous adenocarcinoma of ovary were 73.91% and 30.23% respectively,the difference was significant(P0.001),and the 5-year survival rates were 36.84% and 73.33% respectively;the recurrent rates were 40.9% and 21.43% respectively(P0.05),and OCCC were often combined with endometriosis(22.64%).The conventional satisfactory cytoreductive surgery could not improve their prognosis.Compared to OSCC,the 5-year survival rate of OCCC was only 36.36% and had significant difference(P=0.02).The patients undertaken Paclitaxel-platinum-based chemotherapy had higher effective rate(33.33%) than that undertaken conventional platinum-based chemotherapy(26.32%)(P=0.10).Conclusion: The early stage patients with the clear cell carcinoma of the ovary are easier to get recurrence,and have significantly lower response rate to chemotherapy.The chemotherapy effective rate has no significant difference between paclitaxel-platinum-based chemotherapy and conventional platinum-based chemotherapy.The maximally dissection of the tumor may improve the prognosis of OCCC.