The Relationship Between the Serum CA125 Level and the Outcomes of In Vitro Fertilization in Endometriosis

Objective:To study the relationship between the serum CA125 level before IVF-ET and the outcomes of IVF-ET in infertile patients with endometriosis (EMs). Methods: The serum CA125 levels were measured in the EMs group (65 patients, 67 cycles, with moderate-severe EMs infertility) and the control group (78 patients, 78cycles, with tubal infertility) during non-menstrual phase before controlled ovarian hyperstimulation. The outcomes of IVF-ET and the levels of serum CA125 were analyzed in the both groups. Results: The incidence of adverse outcomes of IVF-ET in the EMs group was higher than the control group (P=0.044), and the serum CA125 levels of patients with adverse outcomes were significantly higher than the control group (P=0.000). In the EMs group, the levels of serum CA125 with adverse outcomes were markedly higher than the continued pregnancy (P=0.002), and there was significant positive correlation between serum CA125 level and adverse outcome of IVF-ET (rs=0.427, P=0.002). The optimal cut-off value of serum CA125 was 12.37 kU/L. When the serum CA125≥12.37 kU/L was used as a basis, the sensitivity, specificity and accuracy of the evaluation for adverse outcome of IVF-ET were 83% (39/47), 80% (16/20) and 82% (55/67), respectively. Conclusions: The serum CA125≥12.37 kU/L before IVF-ET predicts the possible adverse outcome for the infertile patients with EMs.