Does human P-glycoprotein efflux involve transmembrane alpha helix breakage?
preprint
OA: closed
CC-BY-NC-ND-4.0
Abstract
The occluded conformation suggested in a recent article that revealed a new inward-facing conformation for the human P-glycoprotein may not represent the closing of a gate region but instead an artifact derived from lateral compression in a too small sized nanodisc, used to stabilize the transmembrane domains of the transporter.
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- europepmc
- last seen: 2026-05-19T01:45:01.086888+00:00
- unpaywall
- last seen: 2026-05-23T02:00:01.238055+00:00
License: CC-BY-NC-ND-4.0