Exploring Infertility in Saudi Arabia: Qualitative Insights into IVF Treatment Services and Policy Recommendations

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Alshallali" }, { "@type": "Person", "name": "Deema Saad AL Shawan" } ], "publisher": { "@type": "Organization", "name": "F1000Research", "logo": { "@type": "ImageObject", "url": "https://f1000research.com/img/AMP/F1000Research_image.png", "height": 480, "width": 60 } }, "image": { "@type": "ImageObject", "url": "https://f1000research.com/img/AMP/F1000Research_image.png", "height": 1200, "width": 150 }, "description": " Background Infertility has become a significant issue that requires attention as its prevalence has increased globally and nationally in Saudi Arabia over the past few decades. This study aimed to explore patients’ perceptions towards infertility and in vitro fertilization-related services. Additionally, this study examined the barriers that prevent couples from seeking infertility treatment and IVF in Khobar and Dammam, Saudi Arabia. Methods This study employed a qualitative, hybrid thematic analysis approach. Fifteen participants were included in the study. Participants were divided into three categories: infertility patients, infertility caregivers, and administrative staff working in infertility clinics. Results This study identified four main themes: patients’ experiences, infertility services in Eastern Province, and perceived barriers to receiving treatment. Participants reported that they believed infertility was on the rise, especially male infertility. The reported obstacles included financial burdens, lack of awareness, societal influences, and lengthy, complex treatment processes. Conclusions This study highlights the significant barriers that couples encounter in accessing infertility treatment. These findings emphasize the urgent need for improved public health policies, such as utilizing case management to support patients and incorporating insurance coverage for infertility treatments, along with enhanced support services. 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F1000Research 2026, 14 :1130 ( https://doi.org/10.12688/f1000research.168014.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Research Article Revised Exploring Infertility in Saudi Arabia: Qualitative Insights into IVF Treatment Services and Policy Recommendations [version 2; peer review: 1 approved, 1 approved with reservations] Ameina Ahmed D. Alshallali https://orcid.org/0009-0000-6855-4016 1 , Deema Saad AL Shawan https://orcid.org/0000-0003-4571-3832 1 Ameina Ahmed D. Alshallali https://orcid.org/0009-0000-6855-4016 1 , Deema Saad AL Shawan https://orcid.org/0000-0003-4571-3832 1 PUBLISHED 18 Feb 2026 Author details Author details 1 Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province, Saudi Arabia Ameina Ahmed D. Alshallali Roles: Conceptualization, Data Curation, Formal Analysis, Methodology, Writing – Original Draft Preparation, Writing – Review & Editing Deema Saad AL Shawan Roles: Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Supervision, Writing – Review & Editing OPEN PEER REVIEW DETAILS REVIEWER STATUS This article is included in the Health Services gateway. Abstract Background Infertility has become a significant issue that requires attention as its prevalence has increased globally and nationally in Saudi Arabia over the past few decades. This study aimed to explore patients’ perceptions towards infertility and in vitro fertilization-related services. Additionally, this study examined the barriers that prevent couples from seeking infertility treatment and IVF in Khobar and Dammam, Saudi Arabia. Methods This study employed a qualitative, hybrid thematic analysis approach. Fifteen participants were included in the study. Participants were divided into three categories: infertility patients, infertility caregivers, and administrative staff working in infertility clinics. Results This study identified four main themes: patients’ experiences, infertility services in Eastern Province, and perceived barriers to receiving treatment. Participants reported that they believed infertility was on the rise, especially male infertility. The reported obstacles included financial burdens, lack of awareness, societal influences, and lengthy, complex treatment processes. Conclusions This study highlights the significant barriers that couples encounter in accessing infertility treatment. These findings emphasize the urgent need for improved public health policies, such as utilizing case management to support patients and incorporating insurance coverage for infertility treatments, along with enhanced support services. READ ALL READ LESS Keywords Barriers to infertility treatment, in-vitro fertilization, male factor infertility, female factor infertility, primary infertility, secondary infertility, infertility, IVF Corresponding Author(s) Ameina Ahmed D. Alshallali ( [email protected] ) Deema Saad AL Shawan ( [email protected] ) Close Corresponding authors: Ameina Ahmed D. Alshallali, Deema Saad AL Shawan Competing interests: No competing interests were disclosed. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2026 Alshallali AAD and AL Shawan DS. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Alshallali AAD and AL Shawan DS. Exploring Infertility in Saudi Arabia: Qualitative Insights into IVF Treatment Services and Policy Recommendations [version 2; peer review: 1 approved, 1 approved with reservations] . F1000Research 2026, 14 :1130 ( https://doi.org/10.12688/f1000research.168014.2 ) First published: 17 Oct 2025, 14 :1130 ( https://doi.org/10.12688/f1000research.168014.1 ) Latest published: 31 Mar 2026, 14 :1130 ( https://doi.org/10.12688/f1000research.168014.3 ) Revised Amendments from Version 1 The manuscript was revised to clarify sampling techniques and elaborate on the participant recruitment process. The manuscript was revised to clarify sampling techniques and elaborate on the participant recruitment process. See the authors' detailed response to the review by Emmanuel Ifeanyi Obeagu READ REVIEWER RESPONSES  There is a newer version of this article available. Suppress this message for one day. Introduction Infertility is increasingly recognized as a pressing public health concern affecting millions of individuals and couples worldwide. According to the World Health Organization (WHO), approximately 17.5% of adults experience infertility. 1 Fertility rates in the Middle East and North Africa have fallen since the 1960s, dropping from an average of seven births per woman to 2.6 in 2021. 2 Furthermore, fertility rates in Saudi Arabia have steadily decreased, from 7.6 births per woman in 1960 to 2.46 births per woman in 2020. This surge has led to the global adoption of in vitro fertilization (IVF), which has significantly increased over the last 40 years. Since the first successful IVF birth in 1978, over eight million children have been born using this method. 3 IVF treatment was introduced in the Middle East during the 1980s, starting in Saudi Arabia. Currently, more than 35 centers in the Kingdom of Saudi Arabia (KSA) conduct approximately 20,000 IVF treatment cycles annually, with the majority of these facilities operating within the private sector. 4 The number of centers offering these services varies significantly by region in the Kingdom. In 2012, there were four private centers that provided IVF services and not a single government center in the Eastern Province. 5 In 2019, the first government infertility clinic was established. 5 Despite this remarkable growth, various economic, social, cultural, and structural barriers prevent many individuals struggling with infertility from accessing IVF treatment. 3 The existing literature on perceptions of these services and the factors affecting accessibility in Saudi Arabia is limited. Nevertheless, global studies have shed light on patients’ perceptions and factors influencing their experiences with IVF treatment. For instance, a study conducted on the perceptions of infertility patients from six European countries found that factors such as a lack of knowledge of success rates, the high cost of treatment, and religious beliefs were obstacles to receiving those services. 6 Additionally, studies have found other factors that limit the number of couples seeking infertility treatment, including societal, mental, and economic challenges. 7 The most notable societal influence is the stigma surrounding male infertility, which can lead to a refusal of medical treatment, even when a male factor issue is suspected. 9 The emotional aspects of infertility can prevent patients from pursuing treatment. Gibson and Myers emphasized the need for counselors to be aware of infertile women’s coping needs and specific interventions to help them cope effectively with infertility stress. 10 This study aimed to examine the perceptions of patients with infertility regarding IVF services in the Eastern Province of Saudi Arabia. Additionally, we sought to identify factors that influence the process of seeking and receiving IVF treatment. The findings of this study will provide valuable insights for decision makers, enabling them to enhance the quality and accessibility of these services while fostering more culturally sensitive care. Furthermore, the results will inform the development of policies aimed at enhancing IVF services, ensuring that they are more effective and responsive to patient needs. Methods This study employed a descriptive phenomenological qualitative method, specifically using a hybrid thematic analysis approach that incorporates both deductive and inductive coding. Initially, open coding was performed to organize the textual data and assign codes. This was followed by axial coding, which established the relationships between codes to create subcategories. Finally, selective coding is applied to connect these subcategories, ultimately leading to the development of overarching themes. 11 , 12 The researchers implemented a purposeful sampling technique to select relevant participants. In qualitative research, purposeful sampling is used to identify and select cases relevant to the phenomenon of interest that contain a substantial amount of information. 13 The inclusion criteria specified that the target population consisted of couples seeking IVF treatment in the Eastern Province of Saudi Arabia. Participants were categorized into three groups: patients, physicians, and administrative staff at IVF centers. Those residing outside the Eastern Province were excluded because regional differences in healthcare delivery, culture, and available resources could significantly impact the findings. Furthermore, data collection and analysis were performed concurrently until data saturation was achieved with a sample of 15 participants. Data saturation refers to the stage in qualitative research in which additional data collection no longer generates new insights or themes. 14 Data were collected through individual in-person interviews conducted in infertility clinics in Khobar and Dammam, Eastern Province, Saudi Arabia, except for one interview conducted by phone at the participant’s preference. Participants received consent forms that were read and signed before the interviews were conducted. As for the participant interviewed over the phone, verbal consent was obtained prior to the interview. The interviews ranged from 45 minutes to two hours. To improve the accuracy and reliability of the data, this study used a triangulation method for data sources, aiming to foster a thorough understanding of the phenomena under investigation. Data triangulation involves the use of multiple participants to verify the information gathered, ensuring that the findings are not biased or limited to a single perspective. In this study, data were collected from three different groups of participants: patients with infertility, physicians (infertility specialists), and administrative staff working in infertility clinics. In addition, interviews were conducted in five hospitals. Two of the hospitals were government-run, and three were private. 12 Finally, the interview recordings were transcribed and analyzed using ATLAS.ti after obtaining a copyright license. The analysis involved applying the necessary codes and themes. The study spanned six months, beginning with data collection (conducting interviews) in November 2023. Results Of the 15 participants, five were OBGYN and infertility specialists, seven were patients, and three were administrative staff. Among the seven patients, five were female and two were male, with ages ranging from 19 to 46 years, all of whom were located in Khobar, Eastern Province. Their occupations vary, and include students, nurses, and some who are unemployed. The five physicians consisted of obstetricians, reproductive medicine consultants, and a senior infertility consultant distributed between Khobar and Dammam. Lastly, the three administrative staff members worked as infertility clinic coordinators and nursing consultants, with two based in Khobar and one in Dammam [ Table 1 ]. Table 1. Participant profile. Participant reference number Category Occupation Gender Age Interview setting City Patient 1 Patient Industrial and manufacturing field Male 39 Private clinic Khobar, Eastern Province Patient 2 Patient Student Female 19 Governmental hospital Khobar, Eastern Province Patient 3 Patient Unemployed Female 32 Governmental hospital Khobar, Eastern Province Patient 4 Patient Unemployed Female 43 Governmental hospital Khobar, Eastern Province Patient 5 Patient Nurse Female 35 Private clinic Khobar, Eastern Province Patient 6 Patient Nurse Female 24 Private clinic Khobar, Eastern Province Patient 7 Patient Housing administrator in the water desalination corporation Male 46 Telephone call- private clinic Khobar, Eastern Province Physician 1 Physician Obstetrician Female Did not disclose Governmental hospital Khobar, Eastern Province Physician 2 Physician Consultant in reproductive medicine and IVF Female Did not disclose Private clinic Khobar, Eastern Province Physician 3 Physician Consultant in reproductive medicine and IVF Female Did not disclose Governmental hospital Dammam, Eastern Province Physician 4 Physician Senior consultant in infertility and holder of a master’s degree in ART (assisted reproductive technology) Male Did not disclose Governmental hospital Dammam, Eastern Province Physician 5 Physician Consultant for infertility treatment and assisted reproduction Female Did not disclose Private clinic Khobar, Eastern Province Admin 1 Administrative staff Infertility clinic coordinator Female Did not disclose Governmental hospital Dammam, Eastern Province Admin 2 Administrative staff Nursing consultant Female Did not disclose Governmental hospital Khobar, Eastern Province Admin 3 Administrative staff Nurse supervisor Female Did not disclose Governmental hospital Khobar, Eastern Province Theme 1: Participants’ perceptions of infertility in the Eastern Province The first theme explored the perceptions of infertility among all three participant groups in Khobar and Dammam. Seven out of 15 participants, including health professionals and patients, expressed that they believe infertility is increasing in Saudi Arabia despite the absence of publicly available data. For example, Physician 3 stated, “Recently, there has been an increase in infertility, but I don’t have any figures.” These comments highlight the importance of having access to infertility statistics as they influence perceptions of infertility among both health professionals and patients. The participants also believed that primary infertility was more common than secondary infertility. Additionally, they believed that male factor infertility was the most common reason for seeking treatment. This view was supported by physicians, who mentioned that they had seen more cases of male factor infertility. For instance, Physician 2 stated that “male factor is really one of the things which we are facing. I can tell you that in some reported literature, they’re reaching up to 60% worldwide due to the male factor … I am sure if we currently conduct a study, we may find about 50 to 60% related to male factors” [ Table 2 ]. Table 2. Participants’ perceptions of infertility in the Eastern Province, Saudi Arabia. Theme Quotes Infertility on the rise 7 * “Recently, there has been an increase in infertility, but I don’t have any figures.” Primary infertility is higher than secondary 7 * “Mostly primary is higher than the secondary.” The most common reason due to male factor 6 * “Male factor is really one of the things which we are facing. I can tell you that in some reported literature, they're reaching up to 60% worldwide due to the male factor … I'm sure if we currently conduct a study, we may find about 50 to 60% related to male factors.” * Number of quotes is indicated in parentheses. Theme 2: Perception towards infertility services in the Eastern Province The second theme explored participants’ perceptions of infertility services in both the governmental and private sectors in the Eastern Province. Physicians shared their views on the types of treatments they provided to patients. On the other hand, administrators described how they scheduled infertility patients and the services they offered. The patients explained where they sought treatment, whether in government or private clinics, which services were available to them, and their opinions on those services. This theme was further divided into five sub-themes: limited government resources, lack of male factor treatment, long waiting lists, unnecessary private sector services, and lack of insurance coverage [ Table 3 ]. Table 3. Perception towards infertility services in the Eastern Province. Theme Quotes Limited resources in government services 17 * “We are an educational government hospital. We don’t have a specialized clinic. We have IVF doctors, but they aren’t doing IVF procedures in the hospital.” Unavailable male factor treatment necessities in the government sector in Eastern Province 5 * “We do not have an andrology expert. Until now, we have not had a physician who specializes in treating men's reproductive-related issues, which is one of the basics of the department, honestly.” Long waiting lists 6 * “Since 2019, we have had 400 cases so far and approximately a thousand patients on the waiting list.” Unnecessary services in the private sector 3 * “… We were asked to undergo genetic testing, and I believe that’s cost us a lot of time, and it might delay one of the cycles. We don't think this is necessary in our case, at least.” Lack of insurance coverage 15 * “Of course, it’s not covered at all. Nothing. And by requesting any investigation, just by putting the reason as infertility, even if it was for a baseline investigation, it’s declined. Investigation, diagnosis, and infertility baseline investigation. The patients will pay for it out of pocket.” * Number of quotes is indicated in parentheses. Limited governmental resources According to the participants, currently, only one government center in the Eastern Province offers infertility treatment and accepts referrals from the region. The study participants also reported that a government hospital in Khobar had infertility specialists, but they did not perform procedures such as IVF. The government hospital receives patients with infertility, orders tests, performs ultrasound, and provides consultations. However, patients are referred to a single government infertility clinic in Dammam and placed on a long waiting list, referred to the government infertility clinic in Riyadh, or continue with necessary procedures at a private infertility clinic. It is essential to note that the scarcity of government infertility services was perceived as a significant issue in all three categories. As Admin 3 mentioned, “we are an educational government hospital. We do not have a specialized clinic. We have IVF doctors, but they are not performing IVF procedures in the hospital.” Moreover, Physician 2 stated, “… the government or the public centers are not sufficient to accommodate the number of patients.” Additionally, Patient 3 said, “I wish they had an in vitro fertilization procedure. All hospitals are supposed to offer it.” Lack of male factor treatment in the Eastern Province The participants disclosed that they believed that the only governmental infertility center in the region lacked an andrologist. Therefore, in cases requiring such a specialist, patients must be referred to a different region for treatment. Additionally, the participants reported that certain procedures related to male factors were not available at the government center. According to Admin 1, “We do not have an andrology expert. Until now, we have not had a physician who specializes in honestly treating men’s reproductive-related issues, which is one of the basics of the department.” Long waiting list According to the participants, the current waiting list at the governmental infertility clinic in the Eastern Province is approximately 1,000 patients. This issue was mentioned by several patients, such as Patient 3, who noted that “IVF appointments can sometimes be held one year after being arranged.” Moreover, Admin 1 disclosed that “Since 2019, we have had 400 cases so far and approximately a thousand patients on the waiting list.” Unnecessary services in the private sector Participants mentioned that some private hospitals ordered what they believed as unnecessary services, such as genetic testing. According to Patient 1, “… We were asked to undergo genetic testing, and I believe that it cost us a lot of time, and it might delay one of the cycles. We do not think this is necessary in our case, at least.” Lack of insurance coverage Physicians, patients, and administrators in this study emphasized the importance of including infertility treatments under insurance coverage, stating that it is a medical condition that individuals should be able to treat. Similar to other health issues, it requires consultation and care. Physician 1 said about having children, “It’s one of the basic needs in life. It is not an accessory or a supplementary need; on the contrary, having children is one of life’s necessities, especially in Arab culture.” This view was echoed by Patient 6, who said, “It is expensive, and I do not know why insurance does not cover it, honestly, it’s unfair. It is the same as any health condition; it should be treated similarly. How is it the fault of the person if they cannot have children?” Additionally, Admin 2 mentioned, “We do not have this service in our educational governmental hospital, and the people struggle to save for a cycle to do it in a private place and the insurance usually do not cover the IVF cycle. It’s very stressful.” Theme 3: Perceived barriers facing infertility patients The third theme concerns the perceived barriers that prevent patients with infertility from seeking treatment from the participants’ perspective. This theme was further divided into five sub-themes: financial burden, lack of awareness, societal influences, the duration and complexity of the process, and the impact of these factors on individuals [ Table 4 ]. Table 4. Perceived barriers facing infertility patients seeking IVF, in the Eastern Province, Saudi Arabia. Theme Quotes Financial burden 20 * “Patients have a huge financial burden because most insurance companies do not cover it. Having a few public hospitals creates a lot of emotional stress and financial stress on patients.” Lack of awareness and proper guidance 13 * “I feel that I was late in seeking treatment due to unawareness. If I had known earlier on, I could’ve gotten treatment.” Limited in fertility centers 10 * “For us, as an educational governmental hospital, since it is only a clinic and there are no procedures, giving is limited only to the lab work and ultrasound, which means we can only do simple things that do not complete the entire process.” Societal influences 11 * “We have a blaming culture. We have this pressure from family and society. Come on, you didn’t get pregnant. Come on, bring a brother or sister.” Duration and complexity of the process 4 * “Travelling to do such a procedure is not an easy decision because it's not a one-day procedure. You know, it's a back-and-forth process, and it will take about a month for various ultrasounds, blood work, follow-ups, and sometimes the patient herself needs to be in complete rest. So, you need to rent accommodation. It's a hassle.” * Number of quotes is indicated in parentheses. Financial burden The most common obstacle mentioned by patients is the financial burden of infertility treatment. For example, Patient 3 expressed her view on how costly infertility treatments can be by saying, “… another person can go to a private clinic and pay twenty thousand or thirty thousand, but others cannot pay such an amount.” Physicians and administrative staff also confirmed this, sharing their opinions on the high costs of these procedures and their beliefs that they should be covered by health insurance. According to Physician 2, “… Patients face a huge financial burden because most insurance companies do not cover it. Having a few public hospitals creates a lot of emotional and financial stress on patients.” Admin 2 also shared her perspective on how cost impacts seeking treatment by saying, “… I think many no longer seek IVF treatments, although they are desperate for a child because they can’t afford it.” Lack of awareness Infertile patients perceived a lack of awareness and proper guidance, as they sometimes felt lost and unsure how or when to take the next step, since they were not guided properly. Some patients reported that their lack of knowledge prevented them from seeking treatment because they were unaware of the consequences of not seeking treatment at an early stage. For instance, physician 3 stated that “others might have a lack of information; they may not know that IVF is available in government hospitals, so that might delay seeking treatment.” Another reason is wasting time by visiting non-specialized clinics, which also delays seeking proper management. This finding highlights the importance of public health interventions to promote infertility awareness. Societal influences Another barrier mentioned was societal influences and the pressure to have children, which can have the opposite effect and discourage participants from seeking treatment because they do not want to admit to family members that they are suffering from infertility. Patient 6 said, “I felt pressured by family members to have children. I was asked why I had not had children yet, and I felt I would let my family down if they knew about my infertility struggles.” This also influenced her decision not to seek treatment, since she was afraid that it would be unsuccessful and disappoint those around her. She also stated that “we have a blaming culture … we have this pressure from family and society…” Duration and complexity of the process Infertility treatment can vary greatly, but it is often a lengthy process. Patient 1 described the level of commitment required during IVF cycles, emphasizing the importance of careful planning due to the precision needed in daily injections, oocyte retrieval, and embryo transfer. According to Patient 1, “this process demands not only a high level of commitment …, which can discourage patients from proceeding with treatment.” This issue is amplified by a lack of relevant services in the region, which prompts patients to travel frequently according to Patient 3; “traveling to perform such a procedure is not an easy decision because it is not a one-day procedure. You know, it is a back-and-forth process, and it will take about a month for various ultrasounds, blood work, follow-ups, and sometimes the patient needs to be in complete rest. Therefore, you need to rent accommodation. It’s a hassle”. Physician 1 added, “Another burden is that some patients struggle to adhere to the treatment plan because it requires frequent visits. IVF typically involves at least four visits to the clinic for procedures and embryo transfers. However, many patients have work commitments and cannot take time off for every appointment, which complicates compliance.” Discussion This study aimed to discover participants’ perceptions towards infertility and IVF-related services, and to explore the barriers to seeking treatment. Key findings highlight that infertility is perceived to be on the rise, with a significant emphasis on male factor infertility as a prevalent issue. Participants reported barriers to accessing infertility services, including financial burden, lack of awareness, societal influences, and lengthy, complex treatment processes. The limited availability of government resources and the absence of insurance coverage for infertility treatments further exacerbate these challenges. Patients expressed that the length and complexity of the IVF treatment process were major obstacles, especially when most couples go through more than one cycle before success. A study conducted in the UK on live birth rates associated with repeated IVF cycles supported this finding, finding that three out of 10 women succeeded with their first cycle of IVF, while seven out of 10 succeeded by their sixth cycle. 15 In this study, the financial burden was another commonly cited barrier. This result aligns with that of a qualitative research conducted by Mosalanejad et al., who stated that treatment cost is the greatest barrier, even for people with high incomes. 8 Similarly, Insogna et al. mentioned that cost was reported as a barrier to care by 62.8% of the respondents. 16 The patients also expressed that they felt that they were not properly guided or informed. This prevented them from seeking treatment, either because they lacked knowledge of their condition or when to take the next step, This could lead to discontinuation of treatment, which aligns with the findings of Mosalanejad et al. 8 Another factor shared by participants was that one governmental center offering infertility treatment in the Eastern Province was not sufficient. This obstacle was also supported by Fahimi et al., and Mosalanejad et al. also mentioned the lack of infertility centers as a barrier. 8 , 17 Another obstacle reported by several participants was the stigma surrounding infertility and its societal influence. Patients shared experiencing pressure from their families to conceive and fear disappointing them if the treatment failed. Cultural stigma surrounding male infertility has also been noted. Traditionally, women were seen as responsible for infertility, and men were hesitant to get tested due to fear of judgment, stigma, or damage to their masculinity. Agarwal et al. also recognized this issue and suggested increasing awareness and encouraging society to reduce barriers to infertility stigmas rooted in cultural beliefs. 18 Health insurance coverage does not include infertility treatment. Some cases are able to have their insurance cover part of the testing, but the procedures are largely not covered. Thus, the procedures can be costly for patients, which creates a barrier to treatment. The participants mentioned that insurance should cover infertility treatment because infertility is a medical condition similar to any other condition. This finding was supported by Jain et al. and Peipert et al., who concluded that comprehensive mandated insurance coverage increased the utilization of these services, but decreased multiple birth rates. 19 , 20 This factor was also supported by Al-Turki, who noted that a limited number of government hospitals in the Eastern Province offered IVF. The demand for more government infertility centers is clearly high due to the lack of insurance coverage and the number of patients who cannot afford to pay out-of-pocket for treatment in the private sector. 5 One limitation of this study was the lack of current infertility statistics in Saudi Arabia. Owing to the sensitive nature of the research topic, it was challenging to find patients, particularly men, who were willing to share their experiences. As a result, most participants were women, which limits the male perspective in this study. Additionally, information about the private sector is not publicly available, and staff at private clinics are hesitant to be interviewed or share how they manage their infertility clinics and patients. This may have affected the study’s results by limiting insights into private clinic administrative perspectives and emphasizing those of government hospitals. Conclusions This study examines public perceptions and attitudes toward IVF-related services to identify the barriers encountered when seeking treatment. These findings reveal a growing concern regarding infertility, particularly highlighting male factor infertility as a significant issue. Participants identified several obstacles to accessing infertility services, including financial constraints, insufficient awareness, societal pressures, and the lengthy and complicated nature of the treatment processes. Additionally, the limited availability of government resources and lack of insurance coverage for infertility treatments further intensify these challenges. Patients without insurance coverage should be able to receive treatment at government clinics. Moreover, there should be sufficient government clinics to accommodate patients who cannot afford treatment and who lack insurance coverage. 21 Owing to the challenges encountered when interviewing administrative staff in private infertility clinics, there should be greater transparency of information, especially with researchers. This will help provide a comprehensive understanding of infertility services available in both the government and private sectors. Access to data can support further research on infertility and improve current infertility services by offering information and insights to decision makers. Dyer and Zegers-Hochschild highlighted the potential impact of registries on reproductive health. By utilizing registry data, individual centers and countries can benchmark their performance against national, regional, and global standards, thereby providing valuable insights for research. This aligns with the findings of Abduljabbar and Amin, who noted that Saudi Arabia could enhance its international contributions to Assisted Reproductive Technology practices by establishing a government-managed IVF registry, thereby facilitating the global exchange of information. 22 Public health campaigns aimed at raising awareness about infertility causes, prevention, and treatment options can encourage early diagnosis and intervention, which will result in better outcomes. Furthermore, community awareness and engagement are key to lowering cultural stigmas. Finally, to address one of the patients’ main concerns, navigating the complex and lengthy process of infertility treatment, we propose the use of case management. This policy recommendation can lead to the development of a systematic method in which a specialized professional, typically a nurse or care coordinator, assists patients in navigating intricate IVF procedures. Furthermore, research has demonstrated that this approach can enhance patient satisfaction. It also has the potential to alleviate anxiety and depression in individuals who have experienced pregnancy loss following in vitro fertilization and embryo transfer. Implementing such a policy in Saudi hospitals could streamline the process and positively impact patients’ mental health and overall quality of life. 23 Ethics and consent Ethical approval in accordance with the Declaration of Helsinki was obtained from the Institutional Review Board of Imam Abdulrahman Bin Faisal University. The IRB number was IRB-PGS-2023-03-259. All participants’ information and interviews were handled with strict confidentiality. Before the interviews began, the participants signed consent forms to confirm their approval to participate. Data and software availability The dataset is not publicly available due to research data-sharing restriction policies at our institution. Data and interview transcripts can be made available after removing participant-identifiable information. To request access to the data, please email the author, Ameina Alshallali, at [email protected] . Access will be granted on the condition that you provide the purpose for requesting the dataset. References 1. 1 in 6 people globally affected by infertility. WHO; [cited 2023 Apr 19]. Reference Source 2. World Bank Open Data: World Bank Open Data.[cited 2023 Apr 25]. Reference Source 3. Peipert BJ, Adashi EY, Penzias A, et al. : Global in vitro fertilization utilization: How does the United States compare? F S Rep. 2023 Jun 30; 4 (3): 326–327. PubMed Abstract | Publisher Full Text 4. Almaslami F, Aljunid SM, Ghailan K: Demographic determinants and outcome of in vitro fertilization (IVF) services in Saudi Arabia. J. Int. Med. Res. 2018 Apr; 46 (4): 1537–1544. PubMed Abstract | Publisher Full Text 5. Al-Turki HA: Prevalence of primary and secondary infertility from tertiary center in eastern Saudi Arabia. Middle East Fertility Society Journal. 2015 Dec 1; 20 (4): 237–240. Publisher Full Text 6. The Bertarelli Foundation Scientific Board: Public perception on infertility and its treatment: an international survey. Hum. Reprod. 2000 Feb 1; 15 (2): 330–334. PubMed Abstract | Publisher Full Text 7. Zaake D, Kayiira A, Namagembe I: Perceptions, expectations and challenges among men during in vitro fertilization treatment in a low resource setting: a qualitative study. Fertility Research and Practice. 2019 Jul 4; 5 (1): 6. PubMed Abstract | Publisher Full Text | Free Full Text 8. Mosalanejad L, Parandavar N, Abdollahifard S: Barriers to Infertility Treatment: An Integrated Study. Global J. Health Sci. 2014 Jan; 6 (1): 181–191. Publisher Full Text 9. Mehta A, Nangia AK, Dupree JM, et al. : Limitations and barriers in access to care for male factor infertility. Fertil. 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Med. 2002 Aug 29; 347 (9): 661–666. PubMed Abstract | Publisher Full Text 20. Peipert BJ, Chung EH, Harris BS, et al. : Impact of comprehensive state insurance mandates on in vitro fertilization utilization, embryo transfer practices, and outcomes in the United States. Am. J. Obstet. Gynecol. 2022 Jul; 227 (1): 64.e1–64.e8. PubMed Abstract | Publisher Full Text 21. Lee JC, DeSantis CE, Yartel AK, et al. : Association of state insurance coverage mandates with assisted reproductive technology care discontinuation. Am. J. Obstet. Gynecol. 2023 Mar; 228 (3): 315.e1–315.e14. PubMed Abstract | Publisher Full Text | Free Full Text 22. Abduljabbar HS, Amin R: Assisted reproductive technology in Saudi Arabia. 23. Wu X, Wu Y, Xia M, et al. : Case Management Improves Satisfaction, Anxiety, and Depression of Patients with Pregnancy Loss after in vitro Fertilization and Embryo Transfer. Comput. Math. Methods Med. 2022 Apr 7; 2022 : 1–8. Publisher Full Text Comments on this article Comments (0) Version 3 VERSION 3 PUBLISHED 17 Oct 2025 ADD YOUR COMMENT Comment Author details Author details 1 Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province, Saudi Arabia Ameina Ahmed D. Alshallali Roles: Conceptualization, Data Curation, Formal Analysis, Methodology, Writing – Original Draft Preparation, Writing – Review & Editing Deema Saad AL Shawan Roles: Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Supervision, Writing – Review & Editing Competing interests No competing interests were disclosed. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (3) version 3 Revised Published: 31 Mar 2026, 14:1130 https://doi.org/10.12688/f1000research.168014.3 version 2 Revised Published: 18 Feb 2026, 14:1130 https://doi.org/10.12688/f1000research.168014.2 version 1 Published: 17 Oct 2025, 14:1130 https://doi.org/10.12688/f1000research.168014.1 Copyright © 2026 Alshallali AAD and AL Shawan DS. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Alshallali AAD and AL Shawan DS. Exploring Infertility in Saudi Arabia: Qualitative Insights into IVF Treatment Services and Policy Recommendations [version 2; peer review: 1 approved, 1 approved with reservations] . F1000Research 2026, 14 :1130 ( https://doi.org/10.12688/f1000research.168014.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 2 VERSION 2 PUBLISHED 18 Feb 2026 Revised Views 0 Cite How to cite this report: Obeagu EI. Reviewer Report For: Exploring Infertility in Saudi Arabia: Qualitative Insights into IVF Treatment Services and Policy Recommendations [version 2; peer review: 1 approved, 1 approved with reservations] . F1000Research 2026, 14 :1130 ( https://doi.org/10.5256/f1000research.196152.r460091 ) The direct URL for this report is: https://f1000research.com/articles/14-1130/v2#referee-response-460091 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 02 Mar 2026 Emmanuel Ifeanyi Obeagu , Africa University, Mutare, Zimbabwe Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.196152.r460091 The manuscript needs major revision in the areas pointed below: Major Revision Comments – Abstract Insufficient Conceptual Precision in the Background The background section is overly broad and descriptive, lacking a ... Continue reading READ ALL The manuscript needs major revision in the areas pointed below: Major Revision Comments – Abstract Insufficient Conceptual Precision in the Background The background section is overly broad and descriptive, lacking a clear articulation of the specific knowledge gap this study addresses. While infertility prevalence is mentioned globally and nationally, the abstract does not sufficiently justify why patients’ perceptions and barriers in Khobar and Dammam warrant focused investigation, nor how this study advances existing literature. The authors should explicitly state the unmet research gap and the study’s unique contribution. Objectives Require Greater Clarity and Analytical Focus The study aims are stated in a generalized manner and conflate perceptions, service evaluation, and barriers without clearly distinguishing primary and secondary objectives. The abstract should clearly specify whether the central focus is patient perception, service accessibility, systemic barriers, or policy implications, and how these components are analytically linked. Methodological Description Lacks Rigor and Transparency The methods section is insufficiently detailed for a qualitative study. The term “qualitative, hybrid thematic analysis” is vague and not adequately explained. The abstract should briefly clarify what is meant by “hybrid” (e.g., inductive–deductive), the data collection method (e.g., interviews, focus groups), and the rationale for including three distinct participant groups. Additionally, justification for the small sample size (n=15) and its adequacy for thematic saturation is absent. Results Section Is Incomplete and Conceptually Inconsistent There is an inconsistency in the reporting of themes: the abstract states that four themes were identified but lists only three . This is a major structural flaw. Furthermore, the results are presented at a superficial level, largely restating common assumptions (e.g., financial burden, societal influence) without highlighting novel, context-specific insights. The authors should succinctly articulate the most salient and distinctive findings emerging from the data. Conclusions Are Overgeneralized and Not Fully Grounded in the Results The conclusions section introduces policy recommendations (e.g., case management, insurance coverage) that are not clearly tied to the reported findings within the abstract. The authors should ensure that conclusions logically flow from the stated results and avoid introducing new concepts not previously mentioned. The implications should be framed cautiously, reflecting the qualitative nature and limited sample size of the study. Language, Structure, and Technical Accuracy Require Improvement The abstract contains grammatical errors (e.g., “his study” instead of “This study”) and stylistic inconsistencies that detract from clarity and professionalism. The abstract should be carefully edited for language precision, coherence, and alignment with standard structured abstract conventions. Introduction Improve the introduction by expanding. Add the following references in the introduction to improve the background with recent findings: Ref 1, 2 and 3. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Partly If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes References 1. Obeagu E, Obeagu G: Hematological factors in women with Asherman syndrome and primary infertility: An overview. Medicine . 2025; 104 (43). Publisher Full Text 2. Obeagu EI, Njar VE, Obeagu GU: Infertility: Prevalence and consequences. Int J Curr Res Chem Pharm Sci . 2023. 3. Obeagu EI, Obeagu GU: Antioxidants as Potential Therapeutics for Improving Female Fertility: A Narrative Review. Int J Curr Res Chem Pharm Sci . 2024. Competing Interests: No competing interests were disclosed. Reviewer Expertise: Haematology, Immunology, Public Health, Oncology I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Obeagu EI. Reviewer Report For: Exploring Infertility in Saudi Arabia: Qualitative Insights into IVF Treatment Services and Policy Recommendations [version 2; peer review: 1 approved, 1 approved with reservations] . F1000Research 2026, 14 :1130 ( https://doi.org/10.5256/f1000research.196152.r460091 ) The direct URL for this report is: https://f1000research.com/articles/14-1130/v2#referee-response-460091 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 31 Mar 2026 Deema AL Shawan , Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia 31 Mar 2026 Author Response Dear reviewer, Thank you for your valuable input. Blew, please find point-by-point responses to your comments regarding our abstract and introduction section accordingly. Comment: “ Background ... Continue reading Dear reviewer, Thank you for your valuable input. Blew, please find point-by-point responses to your comments regarding our abstract and introduction section accordingly. Comment: “ Background The background section is overly broad and descriptive, lacking a clear articulation of the specific knowledge gap this study addresses. While infertility prevalence is mentioned globally and nationally, the abstract does not sufficiently justify why patients’ perceptions and barriers in Khobar and Dammam warrant focused investigation, nor how this study advances existing literature. The authors should explicitly state the unmet research gap and the study’s unique contribution.” Response: This was done as well as I could without exceeding the word limit of the abstract, which is three hundred words. Comment: “ Objectives Require Greater Clarity and Analytical Focus The study aims are stated in a generalized manner and conflate perceptions, service evaluation, and barriers without clearly distinguishing primary and secondary objectives. The abstract should clearly specify whether the central focus is patient perception, service accessibility, systemic barriers, or policy implications, and how these components are analytically linked.” Response: There are two objectives (aims) to the study, both of which have been edited to make them more concise and briefly explained in the background section of the abstract. Comment “Methodological Description Lacks Rigor and Transparency The methods section is insufficiently detailed for a qualitative study. The term “qualitative, hybrid thematic analysis” is vague and not adequately explained. The abstract should briefly clarify what is meant by “hybrid” (e.g., inductive–deductive), the data collection method (e.g., interviews, focus groups), and the rationale for including three distinct participant groups. Additionally, justification for the small sample size (n=15) and its adequacy for thematic saturation is absent.” Response: The recommended information has been added to the methods section, but was kept brief due to the concise nature of the abstract and further elaborated in the manuscript. Comment “ Results Section Is Incomplete and Conceptually Inconsistent There is an inconsistency in the reporting of themes: the abstract states that four themes were identified but lists only three . This is a major structural flaw. Furthermore, the results are presented at a superficial level, largely restating common assumptions (e.g., financial burden, societal influence) without highlighting novel, context-specific insights. The authors should succinctly articulate the most salient and distinctive findings emerging from the data.” Response: Thank you for highlighting the error it was corrected and further elaboration were added to the results in the abstract. “Conclusions Are Overgeneralized and Not Fully Grounded in the Results The conclusions section introduces policy recommendations (e.g., case management, insurance coverage) that are not clearly tied to the reported findings within the abstract. The authors should ensure that conclusions logically flow from the stated results and avoid introducing new concepts not previously mentioned. The implications should be framed cautiously, reflecting the qualitative nature and limited sample size of the study.” Response: In accordance with this recommendation, the conclusion section in the abstract was edited accordingly. Comment: “ Language, Structure, and Technical Accuracy Require Improvement The abstract contains grammatical errors (e.g., “his study” instead of “This study”) and stylistic inconsistencies that detract from clarity and professionalism. The abstract should be carefully edited for language precision, coherence, and alignment with standard structured abstract conventions. “ Response: Thank you for your feedback. All grammatical errors have been corrected. Comment” Introduction Improve the introduction by expanding. Add the following references in the introduction to improve the background with recent findings: Ref 1, 2 and 3.” Response: I thoroughly read the three references and found them very insightful. I have included Reference 2 since it is most relevant to our study. Dear reviewer, Thank you for your valuable input. Blew, please find point-by-point responses to your comments regarding our abstract and introduction section accordingly. Comment: “ Background The background section is overly broad and descriptive, lacking a clear articulation of the specific knowledge gap this study addresses. While infertility prevalence is mentioned globally and nationally, the abstract does not sufficiently justify why patients’ perceptions and barriers in Khobar and Dammam warrant focused investigation, nor how this study advances existing literature. The authors should explicitly state the unmet research gap and the study’s unique contribution.” Response: This was done as well as I could without exceeding the word limit of the abstract, which is three hundred words. Comment: “ Objectives Require Greater Clarity and Analytical Focus The study aims are stated in a generalized manner and conflate perceptions, service evaluation, and barriers without clearly distinguishing primary and secondary objectives. The abstract should clearly specify whether the central focus is patient perception, service accessibility, systemic barriers, or policy implications, and how these components are analytically linked.” Response: There are two objectives (aims) to the study, both of which have been edited to make them more concise and briefly explained in the background section of the abstract. Comment “Methodological Description Lacks Rigor and Transparency The methods section is insufficiently detailed for a qualitative study. The term “qualitative, hybrid thematic analysis” is vague and not adequately explained. The abstract should briefly clarify what is meant by “hybrid” (e.g., inductive–deductive), the data collection method (e.g., interviews, focus groups), and the rationale for including three distinct participant groups. Additionally, justification for the small sample size (n=15) and its adequacy for thematic saturation is absent.” Response: The recommended information has been added to the methods section, but was kept brief due to the concise nature of the abstract and further elaborated in the manuscript. Comment “ Results Section Is Incomplete and Conceptually Inconsistent There is an inconsistency in the reporting of themes: the abstract states that four themes were identified but lists only three . This is a major structural flaw. Furthermore, the results are presented at a superficial level, largely restating common assumptions (e.g., financial burden, societal influence) without highlighting novel, context-specific insights. The authors should succinctly articulate the most salient and distinctive findings emerging from the data.” Response: Thank you for highlighting the error it was corrected and further elaboration were added to the results in the abstract. “Conclusions Are Overgeneralized and Not Fully Grounded in the Results The conclusions section introduces policy recommendations (e.g., case management, insurance coverage) that are not clearly tied to the reported findings within the abstract. The authors should ensure that conclusions logically flow from the stated results and avoid introducing new concepts not previously mentioned. The implications should be framed cautiously, reflecting the qualitative nature and limited sample size of the study.” Response: In accordance with this recommendation, the conclusion section in the abstract was edited accordingly. Comment: “ Language, Structure, and Technical Accuracy Require Improvement The abstract contains grammatical errors (e.g., “his study” instead of “This study”) and stylistic inconsistencies that detract from clarity and professionalism. The abstract should be carefully edited for language precision, coherence, and alignment with standard structured abstract conventions. “ Response: Thank you for your feedback. All grammatical errors have been corrected. Comment” Introduction Improve the introduction by expanding. Add the following references in the introduction to improve the background with recent findings: Ref 1, 2 and 3.” Response: I thoroughly read the three references and found them very insightful. I have included Reference 2 since it is most relevant to our study. Competing Interests: No competing interests were disclosed. Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 31 Mar 2026 Deema AL Shawan , Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia 31 Mar 2026 Author Response Dear reviewer, Thank you for your valuable input. Blew, please find point-by-point responses to your comments regarding our abstract and introduction section accordingly. Comment: “ Background ... Continue reading Dear reviewer, Thank you for your valuable input. Blew, please find point-by-point responses to your comments regarding our abstract and introduction section accordingly. Comment: “ Background The background section is overly broad and descriptive, lacking a clear articulation of the specific knowledge gap this study addresses. While infertility prevalence is mentioned globally and nationally, the abstract does not sufficiently justify why patients’ perceptions and barriers in Khobar and Dammam warrant focused investigation, nor how this study advances existing literature. The authors should explicitly state the unmet research gap and the study’s unique contribution.” Response: This was done as well as I could without exceeding the word limit of the abstract, which is three hundred words. Comment: “ Objectives Require Greater Clarity and Analytical Focus The study aims are stated in a generalized manner and conflate perceptions, service evaluation, and barriers without clearly distinguishing primary and secondary objectives. The abstract should clearly specify whether the central focus is patient perception, service accessibility, systemic barriers, or policy implications, and how these components are analytically linked.” Response: There are two objectives (aims) to the study, both of which have been edited to make them more concise and briefly explained in the background section of the abstract. Comment “Methodological Description Lacks Rigor and Transparency The methods section is insufficiently detailed for a qualitative study. The term “qualitative, hybrid thematic analysis” is vague and not adequately explained. The abstract should briefly clarify what is meant by “hybrid” (e.g., inductive–deductive), the data collection method (e.g., interviews, focus groups), and the rationale for including three distinct participant groups. Additionally, justification for the small sample size (n=15) and its adequacy for thematic saturation is absent.” Response: The recommended information has been added to the methods section, but was kept brief due to the concise nature of the abstract and further elaborated in the manuscript. Comment “ Results Section Is Incomplete and Conceptually Inconsistent There is an inconsistency in the reporting of themes: the abstract states that four themes were identified but lists only three . This is a major structural flaw. Furthermore, the results are presented at a superficial level, largely restating common assumptions (e.g., financial burden, societal influence) without highlighting novel, context-specific insights. The authors should succinctly articulate the most salient and distinctive findings emerging from the data.” Response: Thank you for highlighting the error it was corrected and further elaboration were added to the results in the abstract. “Conclusions Are Overgeneralized and Not Fully Grounded in the Results The conclusions section introduces policy recommendations (e.g., case management, insurance coverage) that are not clearly tied to the reported findings within the abstract. The authors should ensure that conclusions logically flow from the stated results and avoid introducing new concepts not previously mentioned. The implications should be framed cautiously, reflecting the qualitative nature and limited sample size of the study.” Response: In accordance with this recommendation, the conclusion section in the abstract was edited accordingly. Comment: “ Language, Structure, and Technical Accuracy Require Improvement The abstract contains grammatical errors (e.g., “his study” instead of “This study”) and stylistic inconsistencies that detract from clarity and professionalism. The abstract should be carefully edited for language precision, coherence, and alignment with standard structured abstract conventions. “ Response: Thank you for your feedback. All grammatical errors have been corrected. Comment” Introduction Improve the introduction by expanding. Add the following references in the introduction to improve the background with recent findings: Ref 1, 2 and 3.” Response: I thoroughly read the three references and found them very insightful. I have included Reference 2 since it is most relevant to our study. Dear reviewer, Thank you for your valuable input. Blew, please find point-by-point responses to your comments regarding our abstract and introduction section accordingly. Comment: “ Background The background section is overly broad and descriptive, lacking a clear articulation of the specific knowledge gap this study addresses. While infertility prevalence is mentioned globally and nationally, the abstract does not sufficiently justify why patients’ perceptions and barriers in Khobar and Dammam warrant focused investigation, nor how this study advances existing literature. The authors should explicitly state the unmet research gap and the study’s unique contribution.” Response: This was done as well as I could without exceeding the word limit of the abstract, which is three hundred words. Comment: “ Objectives Require Greater Clarity and Analytical Focus The study aims are stated in a generalized manner and conflate perceptions, service evaluation, and barriers without clearly distinguishing primary and secondary objectives. The abstract should clearly specify whether the central focus is patient perception, service accessibility, systemic barriers, or policy implications, and how these components are analytically linked.” Response: There are two objectives (aims) to the study, both of which have been edited to make them more concise and briefly explained in the background section of the abstract. Comment “Methodological Description Lacks Rigor and Transparency The methods section is insufficiently detailed for a qualitative study. The term “qualitative, hybrid thematic analysis” is vague and not adequately explained. The abstract should briefly clarify what is meant by “hybrid” (e.g., inductive–deductive), the data collection method (e.g., interviews, focus groups), and the rationale for including three distinct participant groups. Additionally, justification for the small sample size (n=15) and its adequacy for thematic saturation is absent.” Response: The recommended information has been added to the methods section, but was kept brief due to the concise nature of the abstract and further elaborated in the manuscript. Comment “ Results Section Is Incomplete and Conceptually Inconsistent There is an inconsistency in the reporting of themes: the abstract states that four themes were identified but lists only three . This is a major structural flaw. Furthermore, the results are presented at a superficial level, largely restating common assumptions (e.g., financial burden, societal influence) without highlighting novel, context-specific insights. The authors should succinctly articulate the most salient and distinctive findings emerging from the data.” Response: Thank you for highlighting the error it was corrected and further elaboration were added to the results in the abstract. “Conclusions Are Overgeneralized and Not Fully Grounded in the Results The conclusions section introduces policy recommendations (e.g., case management, insurance coverage) that are not clearly tied to the reported findings within the abstract. The authors should ensure that conclusions logically flow from the stated results and avoid introducing new concepts not previously mentioned. The implications should be framed cautiously, reflecting the qualitative nature and limited sample size of the study.” Response: In accordance with this recommendation, the conclusion section in the abstract was edited accordingly. Comment: “ Language, Structure, and Technical Accuracy Require Improvement The abstract contains grammatical errors (e.g., “his study” instead of “This study”) and stylistic inconsistencies that detract from clarity and professionalism. The abstract should be carefully edited for language precision, coherence, and alignment with standard structured abstract conventions. “ Response: Thank you for your feedback. All grammatical errors have been corrected. Comment” Introduction Improve the introduction by expanding. Add the following references in the introduction to improve the background with recent findings: Ref 1, 2 and 3.” Response: I thoroughly read the three references and found them very insightful. I have included Reference 2 since it is most relevant to our study. Competing Interests: No competing interests were disclosed. Close Report a concern COMMENT ON THIS REPORT Version 1 VERSION 1 PUBLISHED 17 Oct 2025 Views 0 Cite How to cite this report: Alyaemni A. Reviewer Report For: Exploring Infertility in Saudi Arabia: Qualitative Insights into IVF Treatment Services and Policy Recommendations [version 2; peer review: 1 approved, 1 approved with reservations] . F1000Research 2026, 14 :1130 ( https://doi.org/10.5256/f1000research.185167.r438620 ) The direct URL for this report is: https://f1000research.com/articles/14-1130/v1#referee-response-438620 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 16 Dec 2025 Asmaa Alyaemni , King Saud University, Riyadh, Riyadh Province, Saudi Arabia Approved VIEWS 0 https://doi.org/10.5256/f1000research.185167.r438620 1.the research question clearly stated and suitable for a qualitative approach 2. Sampling strategy was not specified. 3. The data collection is rigour yet interview guide were not included. 3. the description of the analysis approach should ... Continue reading READ ALL 1.the research question clearly stated and suitable for a qualitative approach 2. Sampling strategy was not specified. 3. The data collection is rigour yet interview guide were not included. 3. the description of the analysis approach should be more clear (thematic analysis, framework analysis, grounded theory coding) and Step-by-step explanation of coding ,e.g. use of multiple coders or peer checking and also evidence of data saturation needs some illustration 4.Trustworthiness (Rigor Criteria); qualitative studies use trustworthiness Criterion. Teh author might want to look for: Credibility: Member checking, prolonged engagement Dependability: Audit trail, clear methodology Confirmability: Reflexivity, researcher positionality Transferability: Thick description, context detail Overall, the paper is very strong and can be indexed. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? No source data required Are the conclusions drawn adequately supported by the results? Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: Heath care administrations research, qualitative studies I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Alyaemni A. Reviewer Report For: Exploring Infertility in Saudi Arabia: Qualitative Insights into IVF Treatment Services and Policy Recommendations [version 2; peer review: 1 approved, 1 approved with reservations] . F1000Research 2026, 14 :1130 ( https://doi.org/10.5256/f1000research.185167.r438620 ) The direct URL for this report is: https://f1000research.com/articles/14-1130/v1#referee-response-438620 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Comments on this article Comments (0) Version 3 VERSION 3 PUBLISHED 17 Oct 2025 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 Version 3 (revision) 31 Mar 26 Version 2 (revision) 18 Feb 26 read Version 1 17 Oct 25 read Asmaa Alyaemni , King Saud University, Riyadh, Saudi Arabia Emmanuel Ifeanyi Obeagu , Africa University, Mutare, Zimbabwe Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2026 Obeagu E. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 02 Mar 2026 | for Version 2 Emmanuel Ifeanyi Obeagu , Africa University, Mutare, Zimbabwe 0 Views copyright © 2026 Obeagu E. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The manuscript needs major revision in the areas pointed below: Major Revision Comments – Abstract Insufficient Conceptual Precision in the Background The background section is overly broad and descriptive, lacking a clear articulation of the specific knowledge gap this study addresses. While infertility prevalence is mentioned globally and nationally, the abstract does not sufficiently justify why patients’ perceptions and barriers in Khobar and Dammam warrant focused investigation, nor how this study advances existing literature. The authors should explicitly state the unmet research gap and the study’s unique contribution. Objectives Require Greater Clarity and Analytical Focus The study aims are stated in a generalized manner and conflate perceptions, service evaluation, and barriers without clearly distinguishing primary and secondary objectives. The abstract should clearly specify whether the central focus is patient perception, service accessibility, systemic barriers, or policy implications, and how these components are analytically linked. Methodological Description Lacks Rigor and Transparency The methods section is insufficiently detailed for a qualitative study. The term “qualitative, hybrid thematic analysis” is vague and not adequately explained. The abstract should briefly clarify what is meant by “hybrid” (e.g., inductive–deductive), the data collection method (e.g., interviews, focus groups), and the rationale for including three distinct participant groups. Additionally, justification for the small sample size (n=15) and its adequacy for thematic saturation is absent. Results Section Is Incomplete and Conceptually Inconsistent There is an inconsistency in the reporting of themes: the abstract states that four themes were identified but lists only three . This is a major structural flaw. Furthermore, the results are presented at a superficial level, largely restating common assumptions (e.g., financial burden, societal influence) without highlighting novel, context-specific insights. The authors should succinctly articulate the most salient and distinctive findings emerging from the data. Conclusions Are Overgeneralized and Not Fully Grounded in the Results The conclusions section introduces policy recommendations (e.g., case management, insurance coverage) that are not clearly tied to the reported findings within the abstract. The authors should ensure that conclusions logically flow from the stated results and avoid introducing new concepts not previously mentioned. The implications should be framed cautiously, reflecting the qualitative nature and limited sample size of the study. Language, Structure, and Technical Accuracy Require Improvement The abstract contains grammatical errors (e.g., “his study” instead of “This study”) and stylistic inconsistencies that detract from clarity and professionalism. The abstract should be carefully edited for language precision, coherence, and alignment with standard structured abstract conventions. Introduction Improve the introduction by expanding. Add the following references in the introduction to improve the background with recent findings: Ref 1, 2 and 3. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Partly If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes References 1. Obeagu E, Obeagu G: Hematological factors in women with Asherman syndrome and primary infertility: An overview. Medicine . 2025; 104 (43). Publisher Full Text 2. Obeagu EI, Njar VE, Obeagu GU: Infertility: Prevalence and consequences. Int J Curr Res Chem Pharm Sci . 2023. 3. Obeagu EI, Obeagu GU: Antioxidants as Potential Therapeutics for Improving Female Fertility: A Narrative Review. Int J Curr Res Chem Pharm Sci . 2024. Competing Interests No competing interests were disclosed. Reviewer Expertise Haematology, Immunology, Public Health, Oncology I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (1) Author Response 31 Mar 2026 Deema AL Shawan, Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia Dear reviewer, Thank you for your valuable input. Blew, please find point-by-point responses to your comments regarding our abstract and introduction section accordingly. Comment: “ Background The background section is overly broad and descriptive, lacking a clear articulation of the specific knowledge gap this study addresses. While infertility prevalence is mentioned globally and nationally, the abstract does not sufficiently justify why patients’ perceptions and barriers in Khobar and Dammam warrant focused investigation, nor how this study advances existing literature. The authors should explicitly state the unmet research gap and the study’s unique contribution.” Response: This was done as well as I could without exceeding the word limit of the abstract, which is three hundred words. Comment: “ Objectives Require Greater Clarity and Analytical Focus The study aims are stated in a generalized manner and conflate perceptions, service evaluation, and barriers without clearly distinguishing primary and secondary objectives. The abstract should clearly specify whether the central focus is patient perception, service accessibility, systemic barriers, or policy implications, and how these components are analytically linked.” Response: There are two objectives (aims) to the study, both of which have been edited to make them more concise and briefly explained in the background section of the abstract. Comment “Methodological Description Lacks Rigor and Transparency The methods section is insufficiently detailed for a qualitative study. The term “qualitative, hybrid thematic analysis” is vague and not adequately explained. The abstract should briefly clarify what is meant by “hybrid” (e.g., inductive–deductive), the data collection method (e.g., interviews, focus groups), and the rationale for including three distinct participant groups. Additionally, justification for the small sample size (n=15) and its adequacy for thematic saturation is absent.” Response: The recommended information has been added to the methods section, but was kept brief due to the concise nature of the abstract and further elaborated in the manuscript. Comment “ Results Section Is Incomplete and Conceptually Inconsistent There is an inconsistency in the reporting of themes: the abstract states that four themes were identified but lists only three . This is a major structural flaw. Furthermore, the results are presented at a superficial level, largely restating common assumptions (e.g., financial burden, societal influence) without highlighting novel, context-specific insights. The authors should succinctly articulate the most salient and distinctive findings emerging from the data.” Response: Thank you for highlighting the error it was corrected and further elaboration were added to the results in the abstract. “Conclusions Are Overgeneralized and Not Fully Grounded in the Results The conclusions section introduces policy recommendations (e.g., case management, insurance coverage) that are not clearly tied to the reported findings within the abstract. The authors should ensure that conclusions logically flow from the stated results and avoid introducing new concepts not previously mentioned. The implications should be framed cautiously, reflecting the qualitative nature and limited sample size of the study.” Response: In accordance with this recommendation, the conclusion section in the abstract was edited accordingly. Comment: “ Language, Structure, and Technical Accuracy Require Improvement The abstract contains grammatical errors (e.g., “his study” instead of “This study”) and stylistic inconsistencies that detract from clarity and professionalism. The abstract should be carefully edited for language precision, coherence, and alignment with standard structured abstract conventions. “ Response: Thank you for your feedback. All grammatical errors have been corrected. Comment” Introduction Improve the introduction by expanding. Add the following references in the introduction to improve the background with recent findings: Ref 1, 2 and 3.” Response: I thoroughly read the three references and found them very insightful. I have included Reference 2 since it is most relevant to our study. View more View less Competing Interests No competing interests were disclosed. reply Respond Report a concern Obeagu EI. Peer Review Report For: Exploring Infertility in Saudi Arabia: Qualitative Insights into IVF Treatment Services and Policy Recommendations [version 2; peer review: 1 approved, 1 approved with reservations] . F1000Research 2026, 14 :1130 ( https://doi.org/10.5256/f1000research.196152.r460091) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/14-1130/v2#referee-response-460091 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2025 Alyaemni A. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 16 Dec 2025 | for Version 1 Asmaa Alyaemni , King Saud University, Riyadh, Riyadh Province, Saudi Arabia 0 Views copyright © 2025 Alyaemni A. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions 1.the research question clearly stated and suitable for a qualitative approach 2. Sampling strategy was not specified. 3. The data collection is rigour yet interview guide were not included. 3. the description of the analysis approach should be more clear (thematic analysis, framework analysis, grounded theory coding) and Step-by-step explanation of coding ,e.g. use of multiple coders or peer checking and also evidence of data saturation needs some illustration 4.Trustworthiness (Rigor Criteria); qualitative studies use trustworthiness Criterion. Teh author might want to look for: Credibility: Member checking, prolonged engagement Dependability: Audit trail, clear methodology Confirmability: Reflexivity, researcher positionality Transferability: Thick description, context detail Overall, the paper is very strong and can be indexed. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? No source data required Are the conclusions drawn adequately supported by the results? Yes Competing Interests No competing interests were disclosed. Reviewer Expertise Heath care administrations research, qualitative studies I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Alyaemni A. Peer Review Report For: Exploring Infertility in Saudi Arabia: Qualitative Insights into IVF Treatment Services and Policy Recommendations [version 2; peer review: 1 approved, 1 approved with reservations] . F1000Research 2026, 14 :1130 ( https://doi.org/10.5256/f1000research.185167.r438620) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/14-1130/v1#referee-response-438620 Alongside their report, reviewers assign a status to the article: Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions Adjust parameters to alter display View on desktop for interactive features Includes Interactive Elements View on desktop for interactive features Competing Interests Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. Consider the following examples, but note that this is not an exhaustive list: Examples of 'Non-Financial Competing Interests' Within the past 4 years, you have held joint grants, published or collaborated with any of the authors of the selected paper. You have a close personal relationship (e.g. parent, spouse, sibling, or domestic partner) with any of the authors. You are a close professional associate of any of the authors (e.g. scientific mentor, recent student). You work at the same institute as any of the authors. 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