geneSTRUCTURE: A Modern Platform for Visualization of Gene Structures

Abstract Even in the era of genomics and pan-genomics, the gene remains the fundamental unit of heredity. Accurate visualization of gene structures provides essential insights into the organization, regulation, and evolution of each gene. Representing elements such as exons, introns, untranslated regions, and functional domains in a clear and interpretable format is particularly important for analyzing complex gene architectures and for communicating results effectively. Despite the availability of several visualization tools, many are limited in their ability to incorporate user-defined annotations or to support interactive and customizable figure generation, which reduces their utility in modern analytical workflows. To address these limitations, we developed geneSTRUCTURE, both command-line-interface and web-based application designed to provide flexible and user-friendly visualization of gene structures based on widely used annotation formats, GFF3 and GTF. In addition to visualizing core gene components, the platform allows users to overlay supplemental annotations, including mutation sites and protein domains, and to adjust layout features in real time. By combining a modern interface with annotation flexibility and high-resolution output, geneSTRUCTURE offers a robust solution for gene-level visualization. Competing Interest Statement The authors have declared no competing interest.