Clinical Study on Dahuang Zhechong Capsule for Treating Endometriosis

Objective:To explore the effect of Dahuang Zhechong capsule(DZC) for treating endometriosis and the influence to prostaglandin(PG).Method:Sixty-seven cases of patients with endometriosis were randomly divided into control group and experimental group,while control group was received mifepristone(12.5 mg daily),and experimental group received DZ,5 tablets bid.The treatment was lasted for 12 weeks.Score of visual analogue scale(VAS) and the score of BB multidimensional scale were investigated,and the level of plasma PGs were determined.Result:VAS score in the experimental group was lower than that in the control group(P0.05).BB multidimensional scale score in the experimental group was lower than that in the control group(P0.01).Level of prostaglandin F2a(PGF2a),prostaglandin E2(PGE2) and thromboxane B2(TXB2) of experimental group was lower than those of control group(P0.05).But level of 6-keto-PGF1a of experimental group was higher than that of control group(P0.01).Conclusion:For treating patients with endometriosis,DZC can improve symptom and signs.The effect of alleviating dysmenorrhea is likely related to regulation of levels of PGs.