Identification of p75 and TrkB receptors role in the incidence of endometriosis and endometrioma tissue invasion onto chorioallantoic membrane
article
OA: diamond
CC0
Abstract
Link of Video Abstact: https://youtu.be/noF1KQ1W7Sk Background: The tropomyosin kinase receptor B (TrkB) and p75 receptors may play a role in the formation of deep endometriosis and are related to the more intense pain in deep nodular endometriosis. Neurotrophins brain-derived neurotrophic factor (BDNF) regulate the survival, growth, and programmed cell death of neurons. This study aimed to explore the expression of BDNF and its receptors in endometriosis and endometrioma tissue invasion implanted in the chorioallantoic membrane (CAM) of chicken eggs. Methods: Peritoneal endometriosis lesion, endometrioma, and eutopic endometrium were taken from 27 women who underwent hysteroscopy/laparoscopy and analyzed with 15 tissue samples in each group. The age of the patients ranged from 22-45 years old. Samples were transplanted into CAM of fertile chicken eggs for five days then harvested, and histological preparations were made using the paraffin method. IHC staining was performed on p75, Ki67, TrkB, and BDNF stains. Invasion analysis and IHC evaluation was performed with a semi quantitative method. Data were analyzed using SPSS Statistics version 25.0. Result: Normal endometrium expressed the highest expression of BDNF than peritoneal endometriosis and endometrioma. The endometrioma expressed the highest expression of TrkB than other tissues. The P75 expression correlated positively with Ki67 expression in peritoneum and endometrioma samples (p = 0.012; p = 0.008). Conclusion: The p75 receptor may have a role in endometriosis tissue proliferation, but this receptor does not play a direct role in the process of tissue invasion into CAM. While proliferation in endometriomas is positively correlated with invasion into CAM, it is not correlated with peritoneal endometriosis.
Full text
2,980 characters
· extracted from
oa-html
· click to expand
Identification of p75 and TrkB receptors role in the incidence of endometriosis and endometrioma tissue invasion onto chorioallantoic membrane
- Agung Dewanto ,
- Muhammad Dimas Reza Rahmana ,
- Regina Arumsari ,
- Nurida Khasanah ,
- Wicesa Nugraha ,
- Vanessa Trizia ,
- Khoiruddin Anshori ,
Agung Dewanto
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito Central Hospital, Jalan Kesehatan Sekip, Yogyakarta, Indonesia ; Department of Obstetrics and Gynecology, Universitas Gadjah Mada–Dr. Sardjito Central Hospital, Jalan Kesehatan, Sekip, Yogyakarta, Indonesia
Search for the other articles from the author in:
Google Scholar | PubMed | BMJ Journal
Muhammad Dimas Reza Rahmana
Department of Women and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, William Henry Duncan Building 6 West Derby Street , Liverpool, United Kingdom
Search for the other articles from the author in:
Google Scholar | PubMed | BMJ Journal
Regina Arumsari
Department of Obstetrics and Gynecology, Universitas Gadjah Mada–Dr. Sardjito Central Hospital, Jalan Kesehatan, Sekip, Yogyakarta, Indonesia
Search for the other articles from the author in:
Google Scholar | PubMed | BMJ Journal
Nurida Khasanah
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito Central Hospital, Jalan Kesehatan Sekip, Yogyakarta, Indonesia
Search for the other articles from the author in:
Google Scholar | PubMed | BMJ Journal
Wicesa Nugraha
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito Central Hospital, Jalan Kesehatan Sekip, Yogyakarta, Indonesia
Search for the other articles from the author in:
Google Scholar | PubMed | BMJ Journal
Vanessa Trizia
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito Central Hospital, Jalan Kesehatan Sekip, Yogyakarta, Indonesia
Search for the other articles from the author in:
Google Scholar | PubMed | BMJ Journal
Khoiruddin Anshori
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito Central Hospital, Jalan Kesehatan Sekip, Yogyakarta, Indonesia ; Biomedical Science Graduate Program, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Jalan Farmako, Sekip Utara, Yogyakarta, Indonesia
Search for the other articles from the author in:
Google Scholar | PubMed | BMJ Journal
- pdf |
- DOI: https://doi.org/10.15562/bmj.v13i1.4877 |
- Published: 2024-01-02
Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.
My notes (saved in your browser only)
Ask this paper
Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works
Condition tags
Citation neighborhood (no data yet)
We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2024) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.
Source provenance
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0
· commercial use OK