Conjunctive tuning and cortical geometry shape predictive visual remapping

Conjunctive tuning and cortical geometry shape predictive visual remapping | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Conjunctive tuning and cortical geometry shape predictive visual remapping Xize Xu, Sachira Denagamage, Anirvan Nandy, Monika Jadi This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7536239/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted You are reading this latest preprint version Abstract Perceptual continuity across saccades depends on pre-saccadic remapping of receptive fields (RFs) of visual neurons, a process driven by corollary discharge (CD). Yet how accurate remapping is achieved within the brain’s non-uniform representation of visual space remains unclear. We present a recurrent network model in which neurons conjunctively tuned to retinotopic location and planned saccade direction integrate CD signals to remap. Pre-saccadic suppression stabilizes this process by counteracting distortions from direction selectivity. The model preserves cell-cell RF relationships and constrains population dynamics to a low-dimensional manifold. Recordings in macaque V2 during cued saccades validate saccade direction selectivity and preserved RF relationships of visual neurons. The model reveals eccentricity-dependent remapping errors due to non-uniform cortical representation, a prediction corroborated by our data. Finally, countervailing distortions in cortical representation reduce remapping errors. By revealing novel properties of visual neurons, our study reconciles the demands of acuity and continuity in the visual cortex. Biological sciences/Neuroscience/Computational neuroscience/Network models Biological sciences/Neuroscience/Visual system/Extrastriate cortex Biological sciences/Neuroscience/Oculomotor system/Saccades Biological sciences/Neuroscience/Sensory processing Biological sciences/Neuroscience/Computational neuroscience/Dynamical systems Full Text Additional Declarations There is NO Competing Interest. Cite Share Download PDF Status: Under Review Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7536239","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":514282488,"identity":"59ceb49f-82c8-4b8d-bd67-69b0162e7b08","order_by":0,"name":"Xize Xu","email":"","orcid":"","institution":"Yale School of Medicine","correspondingAuthor":false,"prefix":"","firstName":"Xize","middleName":"","lastName":"Xu","suffix":""},{"id":514282489,"identity":"52ae5883-8598-4b9c-9c2f-c2cf6e4d129d","order_by":1,"name":"Sachira Denagamage","email":"","orcid":"","institution":"Columbia University","correspondingAuthor":false,"prefix":"","firstName":"Sachira","middleName":"","lastName":"Denagamage","suffix":""},{"id":514282490,"identity":"b7771fb6-858c-447c-823e-73b921960a36","order_by":2,"name":"Anirvan Nandy","email":"","orcid":"https://orcid.org/0000-0002-4225-5349","institution":"Yale University School of Medicine","correspondingAuthor":false,"prefix":"","firstName":"Anirvan","middleName":"","lastName":"Nandy","suffix":""},{"id":514282487,"identity":"2478f8ab-e399-4c4f-aa09-d3e3163de7b4","order_by":3,"name":"Monika Jadi","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA6klEQVRIie3PIQvCQBTA8acHWzmxPov7BMKGIAbxs2wMtNgEi4KTwa1Mswa/gxb7IcxymAcW1w1axCTexDwvCt4/vIPH+4UD0Ol+NB4AEABvdgZo5wtbmYTyFNVIKXg/roFKpBHNOV9OwKxGPhvTCdbBDHdYRFri6PJNAgRFxk40wSbQZFRM0oHNz4b8S+pJYqAX4KClQJ5ALEmG9InTwLookC0DYktCKgxdQPqFCGHz1QKJI7Kwtl6gw2hv2C4kh7h5i+8dv37oZ9fLvWNVzf02LSKf0M9nmcphKJy/6+aj9FA91+l0ur/qBVXRSinu2hDpAAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0003-1092-5026","institution":"Yale School of Medicine","correspondingAuthor":true,"prefix":"","firstName":"Monika","middleName":"","lastName":"Jadi","suffix":""}],"badges":[],"createdAt":"2025-09-04 12:41:07","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-7536239/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-7536239/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":92886370,"identity":"b245d945-8219-42c7-bc25-b1f06eac5434","added_by":"auto","created_at":"2025-10-06 16:32:28","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1696396,"visible":true,"origin":"","legend":"Article File","description":"","filename":"XXSD2025Combo.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7536239/v1_covered_d52fa229-49b5-40ad-990e-f73dc1670653.pdf"}],"financialInterests":"There is \u003cb\u003eNO\u003c/b\u003e Competing Interest.","formattedTitle":"Conjunctive tuning and cortical geometry shape predictive visual remapping","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"nature-portfolio","isNatureJournal":true,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"","title":"Nature Portfolio","twitterHandle":"","acdcEnabled":false,"dfaEnabled":false,"editorialSystem":"ejp","reportingPortfolio":"","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-7536239/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7536239/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Perceptual continuity across saccades depends on pre-saccadic remapping of receptive fields (RFs) of visual neurons, a process driven by corollary discharge (CD). Yet how accurate remapping is achieved within the brain’s non-uniform representation of visual space remains unclear. We present a recurrent network model in which neurons conjunctively tuned to retinotopic location and planned saccade direction integrate CD signals to remap. Pre-saccadic suppression stabilizes this process by counteracting distortions from direction selectivity. The model preserves cell-cell RF relationships and constrains population dynamics to a low-dimensional manifold. Recordings in macaque V2 during cued saccades validate saccade direction selectivity and preserved RF relationships of visual neurons. The model reveals eccentricity-dependent remapping errors due to non-uniform cortical representation, a prediction corroborated by our data. Finally, countervailing distortions in cortical representation reduce remapping errors. By revealing novel properties of visual neurons, our study reconciles the demands of acuity and continuity in the visual cortex.","manuscriptTitle":"Conjunctive tuning and cortical geometry shape predictive visual remapping","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-09-25 09:25:11","doi":"10.21203/rs.3.rs-7536239/v1","editorialEvents":[],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"nature-communications","isNatureJournal":true,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"NCOMMS","sideBox":"Learn more about [Nature Communications](http://www.nature.com/ncomms/)","snPcode":"","submissionUrl":"https://mts-ncomms.nature.com/","title":"Nature Communications","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"ejp","reportingPortfolio":"Nature Communications","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"9556f96b-b885-4827-810c-b2812609ed4e","owner":[],"postedDate":"September 25th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[{"id":54640433,"name":"Biological sciences/Neuroscience/Computational neuroscience/Network models"},{"id":54640434,"name":"Biological sciences/Neuroscience/Visual system/Extrastriate cortex"},{"id":54640435,"name":"Biological sciences/Neuroscience/Oculomotor system/Saccades"},{"id":54640436,"name":"Biological sciences/Neuroscience/Sensory processing"},{"id":54640437,"name":"Biological sciences/Neuroscience/Computational neuroscience/Dynamical systems"}],"tags":[],"updatedAt":"2025-09-25T09:25:11+00:00","versionOfRecord":[],"versionCreatedAt":"2025-09-25 09:25:11","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7536239","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7536239","identity":"rs-7536239","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}