Assessment of the expression of mir-29c, mir-200a and mir-145 in endometrial tissue and the downstream molecules in infertile patients with endometriosis

Objective: To study the expression of mir-29c, mir-200a and mir-145 in endometrial tissue and \nanalyze the downstream molecules in infertile patients with endometriosis. Methods: Female \npatients with infertility caused by endometriosis who were treated in Leshan Maternal and \nChild Health Hospital between May 2014 and February 2017 were selected as the infertility \ngroup of the research, and female patients with infertility caused by male factors over the same \nperiod were selected as the control group of the research. Endometrial tissue was collected \nto detect the expression of mir-29c, mir-200a, mir-145, HOXA-10 and HOXA-11 as well as \ndownstream molecules and adhesion molecules. Results: mir-29c, mir-200a and mir-145 \nexpression in endometrial tissue of infertility group were significantly higher than those of \ncontrol group; HOXA-10, HOXA-11, integrin αvβ3, IGFBP-1, CD44V6, N-cadherin and FAK \nmRNA expression in endometrial tissue of infertility group were significantly lower than those \nof control group and negatively correlated with mir-29c, mir-200a and mir-145 expression \nwhile E-cadherin and FUT4 mRNA expression were significantly higher than those of control \ngroup and positively correlated with mir-29c, mir-200a and mir-145 expression. Conclusion: \nThe highly expressed mir-29c, mir-200a and mir-145 in endometrial tissue can regulate the \nexpression of HOXA-10 and HOXA-11 as well as downstream molecules and adhesion \nmolecules, and influence the endometrial receptivity in infertile patients with endometriosis.