Absence of WDR13 in p53-Null Mice Increases Longevity

Abstract Absence of WDR13 is known to be involved in pancreatic, colon and uterine hyperproliferation. However, a recent study showed its antiproliferative role liver regeneration in response to hepatotoxins. These findings intrigued to study the role of WDR13-null condition in Trp53 knockout mouse to study the tumour predisposition and survival. We report absence of Wdr13 in Trp53-null background alleviates the tumour load, in turn increasing total survival in mouse model.