Ring vaccination campaign reduces the incidence of dog rabies in N’Djaména, Chad

Ring vaccination campaign reduces the incidence of dog rabies in N’Djaména, Chad | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Ring vaccination campaign reduces the incidence of dog rabies in N’Djaména, Chad Louis Perriens, Fatima Abdelrazak Zakaria, Monique Léchenne, Mahamat Fayiz Abakar Alhilou, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7860121/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted You are reading this latest preprint version Abstract Rabies is a neglected vaccine-preventable zoonotic disease, causing a fatal neurological infection in humans and animals. Domestic dogs can maintain rabies and are the primary reservoir of infection to humans. Recent evidence has suggested that rabies cannot be maintained in urban dog populations and requires repeated introduction of exposed dogs. This study aims to assess the role of human-mediated transport on dog rabies incidence in N’Djaména, Chad. To this end, a ring vaccination campaign around the city was conducted from 2022 to 2023, and incoming dogs were vaccinated. Changes in local dog rabies incidence were used to assess the impact of the intervention with a compartmental model. Analysis and simulations of the model confirmed the role of human-mediated transport as a driver of rabies persistence in N’Djaména. Uncertainty analysis showed that the results were robust despite identifiability issues in separating the importation rate and the transmission rate. Health sciences/Diseases/Infectious diseases/Viral infection Health sciences/Health care/Public health/Epidemiology dog rabies control human-mediated transport parameter identifiability Full Text Additional Declarations There is NO Competing Interest. Supplementary Files CleanDataAll2025.xlsx Sheet 1 Cite Share Download PDF Status: Under Review Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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