Differential Tissue Coupled Powering for Battery-Free Injectable Electroceuticals

Differential Tissue Coupled Powering for Battery-Free Injectable Electroceuticals | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Differential Tissue Coupled Powering for Battery-Free Injectable Electroceuticals Adam Khalifa, Han Wu, Sultan Mahmud, Mali Halac, Domenica Baez, and 9 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8082600/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Electroceutrical implants that deliver targeted neural stimulation show strong therapeutic promise, yet wirelessly powering ultra-miniaturized, fully injectable systems remains challenging. Here we present a thread-like injectable neural technology (TINY) powered by a differential tissue-coupled powering (DTCP) scheme. DTCP applies mid-frequency differential potentials across external electrodes on a compact wearable transmitter to deliver energy through tissue to an implant integrating a custom ASIC and PEDOT-coated electrodes. Benchtop studies in agar phantoms reveal that DTCP’s power-transfer efficiency increases with implant length without a proportional increase in cross-section or overall volume, while maintaining high angular misalignment tolerance. In vivo tests in rat hindlimbs demonstrate wireless sciatic nerve activation, confirming effective transcutaneous energy delivery. A 20-day implantation study further shows stable positioning and minimal tissue response, indicating chronic compatibility. DTCP thus overcomes key limitations of conventional wireless powering and provides a scalable, alignment-robust strategy for minimally invasive electroceutical therapies. Physical sciences/Engineering/Biomedical engineering Physical sciences/Engineering/Electrical and electronic engineering Full Text Additional Declarations There is NO Competing Interest. Supplementary Files Supplement.docx Supplement for Differential Tissue Coupled Powering for Battery-Free Injectable Electroceuticals Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8082600","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":546769419,"identity":"d48d01d7-7ef7-4eb2-ac93-e6cbaa471343","order_by":0,"name":"Adam 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