Mucinous ovarian tumors of Mullerian-type: an analysis of 17 cases including borderline tumors and intraepithelial, microinvasive, and invasive carcinomas
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Analysis of 17 Mullerian-type mucinous ovarian tumors, frequently associated with endometriosis, revealed an indolent clinical course with no recurrences or deaths despite varying histologic features and stages.
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This study analyzed 17 cases of Mullerian-type mucinous ovarian tumors, encompassing borderline lesions and various stages of carcinoma. The cohort demonstrated a predominantly favorable prognosis, with no recurrences or disease-related deaths observed across all patients despite variations in tumor stage, bilaterality, or treatment approach. Notably, endometriosis was present in nearly half of the cases, highlighting a frequent association between these specific ovarian neoplasms and the condition. This paper is centrally about endometriosis — specifically noting its presence in 47% of Mullerian-type mucinous ovarian tumor cases, which supports the hypothesis of an endometriosis-derived origin for this rare tumor subtype.
Abstract
Mullerian-type mucinous tumors (MMTs) of the ovary are characterized by a papillary architecture similar to that of serous tumors and a content of endocervical-like mucinous epithelium. The latter may be admixed with other mullerian-type epithelia, including those of serous, endometrioid, and squamous types, and indifferent eosinophilic epithelial cells. We analyzed 17 MMTs, including 12 borderline tumors, 2 intraepithelial carcinomas, 2 microinvasive carcinomas, and 1 invasive carcinoma. Fourteen of 16 tumors (88%) with available staging were stage I; the remaining two cases (both borderline) were stage IIa and IIIc. Endometriosis was identified in eight cases (47%). Only two patients (12%) had bilateral tumors, a frequency of bilaterality lower than in previous studies. Five patients (31%) had conservative treatment consisting of a cystectomy or unilateral salpingo-oophorectomy. All patients had a favorable outcome, with no recurrences or disease-related deaths, regardless of the presence of high mitotic index, intraepithelial carcinoma, microinvasion, bilaterality, conservative treatment, or advanced stage. This indolent behavior of MMTs is similar to that previously reported, but additional cases of invasive carcinomas in this category are needed to better define their outcome.
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Mucinous Ovarian Tumors of Mullerian-type: An Analysis of 17 Cases Including Borderline Tumors and Intraepithelial, Microinvasive, and Invasive Carcinomas
- Valérie Dubé
- Michel Roy
- Marie Plante
- Marie-Claude Renaud
- Bernard Têtu
Summary:
Mullerian-type mucinous tumors (MMTs) of the ovary are characterized by a papillary architecture similar to that of serous tumors and a content of endocervical-like mucinous epithelium. The latter may be admixed with other mullerian-type epithelia, including those of serous, endometrioid, and squamous types, and indifferent eosinophilic epithelial cells. We analyzed 17 MMTs, including 12 borderline tumors, 2 intraepithelial carcinomas, 2 microinvasive carcinomas, and 1 invasive carcinoma. Fourteen of 16 tumors (88%) with available staging were stage I; the remaining two cases (both borderline) were stage IIa and IIIc. Endometriosis was identified in eight cases (47%). Only two patients (12%) had bilateral tumors, a frequency of bilaterality lower than in previous studies. Five patients (31%) had conservative treatment consisting of a cystectomy or unilateral salpingo-oophorectomy. All patients had a favorable outcome, with no recurrences or disease-related deaths, regardless of the presence of high mitotic index, intraepithelial carcinoma, microinvasion, bilaterality, conservative treatment, or advanced stage. This indolent behavior of MMTs is similar to that previously reported, but additional cases of invasive carcinomas in this category are needed to better define their outcome.
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Condition tags
endometriosis
MeSH descriptors
Adenocarcinoma, Mucinous
Mixed Tumor, Mullerian
Ovarian Neoplasms
Adenocarcinoma, Mucinous
Adenocarcinoma, Mucinous
Adenocarcinoma, Mucinous
Adenocarcinoma, Mucinous
Adolescent
Adolescent
Adult
Adult
Aged
Aged
Aged, 80 and over
Aged, 80 and over
Endometriosis
Endometriosis
Endometriosis
Female
Female
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Source provenance
- europepmc
- last seen: 2026-10-10T06:11:15.153948+00:00
- pubmed
- last seen: 2026-10-08T21:03:04.870308+00:00
- unpaywall
- last seen: 2026-10-10T06:25:47.132674+00:00
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