Persisting active and proliferative intrinsic ureteral endometriosis under GNRH agonists therapy: a case with immunohistological study

Anaf V, V Anaf, Vincent Anaf, M V Vanden Bossche, Marc Vanden Bossche, Vanden Bossche MV, P Simon, Simon P, Ph. Simon, Cristina Riera, Riera C, C Riera, Fayt I, I Fayt, Isabelle Fayt, Noel JC, Jean‐Christophe Noël, J C Noel
European journal of obstetrics, gynecology, and reproductive biology · 2001 · vol. 97(2) , pp. 250–254 · doi:10.1016/s0301-2115(00)00531-5 · PMID:11451560 · W2080985257
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This case study describes a patient with persistent active and proliferative intrinsic ureteral endometriosis that continued despite treatment with GNRH agonists, confirmed by immunohistological analysis.

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Abstract

We report the case of a 30-year-old patient who underwent a segmental ureteral resection with ureteroureterostomy because of the presence of a left ureterohydronephrosis caused by an intrinsic ureteral endometriotic lesion. Preoperatively, the patient received a 3 months course of GNRH agonists. The serum estradiol level was at 12 pg/ml at the moment of surgery. Histology and immunohistochemistry performed on the resected specimen showed the presence of numerous large haemorrhagic endometriotic foci containing very high levels of alpha-estrogen and progesterone nuclear receptors, a high Ki-67 labeling index and a strong positivity for EGF-receptor. This is the first report of immunohistochemical study performed on ureteral endometriosis preoperatively treated with GNRH agonists. Because hormonal treatments are often prescribed in the treatment of ureteral endometriosis, clinicians should be aware of the possibility of persisting very active and proliferative ureteral endometriotic lesions even under treatment with GNRH agonists and very low levels of circulating estradiol.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Goserelin Ureteral Diseases Adult Endometriosis Endometriosis Endometriosis ErbB Receptors ErbB Receptors Estradiol Estradiol Estrogen Receptor alpha Female Goserelin Goserelin Humans Hydronephrosis Hydronephrosis Immunohistochemistry Ki-67 Antigen

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (17)

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