Anginogenesis of eutopic and ectopic endometria in endometriosis

Liu Y, Yi Liu, Liqun Lü, Lü L, Guijin Zhu, Zhu G
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2003 · doi:10.1007/BF02859954 · PMID:12973947
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Ectopic and eutopic endometrial tissues from endometriosis patients exhibited significantly higher vascular surface area and microvessel density compared to normal endometrium, suggesting a role for angiogenesis in endometriosis development.

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The paper quantitatively assessed angiogenesis by comparing eutopic and ectopic endometrial tissues from patients with endometriosis. Using color morphometric image system measurements of vascular surface area and microvessel density (MVD), the authors found that, within each menstrual phase, both vascular surface area and MVD were significantly higher in ectopic endometria than in eutopic endometria from endometriosis patients and in normal endometrium. The main caveat is that the study design is described as observational comparison across tissues and phases, and it does not directly test a causal mechanism beyond proposing involvement of angiogenesis. This paper is centrally about endometriosis — it focuses on angiogenesis differences between eutopic and ectopic endometrial tissue in endometriosis.

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Abstract

In order to study the angiogenesis in endometriosis, the samples of eutopic and ectopic endometria from patients with endometriosis were quantitatively analyzed by color morphometric image system (CMIS) for vascular surface area, and by examining endometrial blood vessel for microvessel density (MVD). The results showed that within each menstrual phase the vascular surface area and MVD were significantly higher in ectopic endometria with endometriosis than those in eutopic endometria with endometriosis or normal endometrium (P < 0.05). It is concluded that angiogenesis might be involved in the development of endometriosis.
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Summary In order to study the angiogenesis in endometriosis, the samples of eutopic and ectopic endometria from patients with endometriosis were quantitatively analyzed by color morphometric image system (CMIS) for vascular surface area, and by examining endometrial blood vessel for microvessel density (MVD). The results showed that within each menstrual phase the vascular surface area and MVD were significantly higher in ectopic endometria with endometriosis than those in eutopic endometria with endometriosis or normal endometrium (P<0.05). It is concluded that angiogenesis might be involved in the development of endometriosis. Similar content being viewed by others References Potgen A J, Lubsen M C, Schoenmakers D Jet al., Vascular permeability factor expression influences tumor angiogenesis in human meanoma lines xenografted to nude mice. Am J Pathol, 1993, 146:147 Koch A E, Harlow G, Haines E,et al. Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis. J Immunol, 1995, 152: 4149 Ravindranath N L, Little-Ihring H S, Phillips Net al. Vascular endothelial growth factor messenger ribonucleic acid expression in the primate ovary. Endocrinology, 1992, 131:254 Breier G, Albrecht U, Sterrer S,et al. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development (Camb.), 1992, 114;521 Smith S K. Angiogenesis. Semin Reprod Endocrinol, 1996, 15:221 Nisolle M F, Cassanas-Roux V, Anaf J Met al. Morphometric study of the stromal vascularition in peritoneal endometriosis. Fertil Steril, 1993, 59:442 Author information Authors and Affiliations Additional information LIU Yi, male, born in 1968, Associate Professor Rights and permissions About this article Cite this article Yi, L., Liqun, L. & Guijin, Z. Anginogenesis of eutopic and ectopic endometria in endometriosis. Current Medical Science 23, 190–191 (2003). https://doi.org/10.1007/BF02859954 Received: Published: Issue date: DOI: https://doi.org/10.1007/BF02859954

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Neovascularization, Pathologic Pelvis Adult Endometriosis Endometriosis Endometrium Female Humans Menstrual Cycle

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