Pyogenic Brain Abscess with haemorrhage as the first radiological presentation of hereditary haemorrhagic telangiectasia

Pyogenic Brain Abscess with haemorrhage as the first radiological presentation of hereditary haemorrhagic telangiectasia | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Pyogenic Brain Abscess with haemorrhage as the first radiological presentation of hereditary haemorrhagic telangiectasia Rashmi Jayakar Poojary, Y Vikhyath Shetty, Rahul Karthik Lingutla, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6268541/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Pulmonary arteriovenous malformations (PAVM) are rare pulmonary vascular anomalies that produce right to left shunt, which may result in septic or non-septic emboli to the systemic circulation, leading to serious central nervous system (CNS) complication like cerebral abscess. We report a case of a pyogenic brain abscess in a 72 year old male demonstrating haemorrhage in its walls on CT and GRE sequence of 1.5T MRI as an initial radiological manifestation, and an incidentally detected PAVM on CT scan of the thorax. Further workup revealed multiple telangiectasia in liver and angiodysplasia in stomach suggesting hereditary haemorrhagic telangiectasia. Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6268541","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":439565816,"identity":"7089011e-78f7-4384-b364-01ffb0dc4bbe","order_by":0,"name":"Rashmi Jayakar Poojary","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA+klEQVRIiWNgGAWjYHACNgYGAyB1AIg+/rMBshgbDxCt5eAMtjSQlgYitDBAtDDzsB2GsXED8/bjzx7dKGBI7LuRe/AwD895u7Xth4G21NhE49IicybH3DjHgCFx5o28hINzJG4nbzuTCNRyLC23AYcWCYYcNmmQlg03cgwOvDG4nWx2AKiFseEwbi38z58htPAknEs2O/+QgBaJBDO4loM8Bw7Ymd0gZIvEG5AWCeOZZ94lHJzZkJxgdgNoSwI+v/CnAx32x0a273ju4Q8fG+zszc6nP3zwocYGpxZ4KDAw8IBZiWCVCfiVwwBEiz1xikfBKBgFo2AkAQD7PmeNWEElTwAAAABJRU5ErkJggg==","orcid":"","institution":"Manipal Hospital","correspondingAuthor":true,"prefix":"","firstName":"Rashmi","middleName":"Jayakar","lastName":"Poojary","suffix":""},{"id":439565817,"identity":"f5191a99-e78c-47b0-bc9f-40527ca254e5","order_by":1,"name":"Y Vikhyath Shetty","email":"","orcid":"","institution":"Manipal Hospital","correspondingAuthor":false,"prefix":"","firstName":"Y","middleName":"Vikhyath","lastName":"Shetty","suffix":""},{"id":439565818,"identity":"16dcf028-efce-4545-a631-221fc6fb69ba","order_by":2,"name":"Rahul Karthik Lingutla","email":"","orcid":"","institution":"Manipal Hospital","correspondingAuthor":false,"prefix":"","firstName":"Rahul","middleName":"Karthik","lastName":"Lingutla","suffix":""},{"id":439565819,"identity":"77c56081-0f78-4420-8d78-ecaa98aadccd","order_by":3,"name":"Madhu Kumar S B","email":"","orcid":"","institution":"Manipal Hospital","correspondingAuthor":false,"prefix":"","firstName":"Madhu","middleName":"Kumar S","lastName":"B","suffix":""},{"id":439565820,"identity":"65621c50-d4b5-4d82-af8b-b05ad75e0048","order_by":4,"name":"Dhineshkumar Thirumoorthy","email":"","orcid":"","institution":"Manipal Hospital","correspondingAuthor":false,"prefix":"","firstName":"Dhineshkumar","middleName":"","lastName":"Thirumoorthy","suffix":""}],"badges":[],"createdAt":"2025-03-20 10:08:21","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6268541/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6268541/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":100414491,"identity":"a3f47977-e39d-4416-be6e-c7d28920a9c4","added_by":"auto","created_at":"2026-01-16 13:19:29","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":637356,"visible":true,"origin":"","legend":"","description":"","filename":"HHTREPORT.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6268541/v1_covered_1f641d64-cb4b-438f-aaee-4babc947c14a.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Pyogenic Brain Abscess with haemorrhage as the first radiological presentation of hereditary haemorrhagic telangiectasia","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-6268541/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6268541/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003ePulmonary arteriovenous malformations (PAVM) are rare pulmonary vascular anomalies that produce right to left shunt, which may result in septic or non-septic emboli to the systemic circulation, leading to serious central nervous system (CNS) complication like cerebral abscess.\u003c/p\u003e \u003cp\u003eWe report a case of a pyogenic brain abscess in a 72 year old male demonstrating haemorrhage in its walls on CT and GRE sequence of 1.5T MRI as an initial radiological manifestation, and an incidentally detected PAVM on CT scan of the thorax. 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