Effects of endometriosis on pregnancy outcomes in Fujian province

Z-Z Liu, Liu Zz, S-J Tang, X Chen, Xiao‐Dong Chen, J-Y Wang, Jiu‐Yao Wang, Y-L Zhang, YL Zhang
European review for medical and pharmacological sciences · 2023 · vol. 27(22) , pp. 10968–10978 · doi:10.26355/eurrev_202311_34465 · PMID:38039027 · W4389244466
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study found that endometriosis in pregnant women is associated with increased rates of preeclampsia, placenta previa (especially with more severe disease), and postpartum hemorrhage compared to women without endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

This retrospective study analyzed pregnancy complications and neonatal outcomes in 3,809 women who were examined, hospitalized, and delivered by cesarean section in Fujian Maternal and Child Health Hospital (2014–2020), comparing 1,026 with endometriosis diagnosed after delivery to 2,783 without endometriosis. The authors report that preeclampsia and placenta previa were more common in the endometriosis group than in controls, while most other complications (including GDM, ICP, PROM, and placental abruption) did not differ. Severity-stratified analysis showed higher placenta previa incidence in stage III/IV versus stage I/II, and postpartum hemorrhage volume was greater in the endometriosis group, although postpartum hemorrhage incidence did not differ by stage. Limitations include reliance on retrospective records and diagnosis of endometriosis after cesarean delivery. This paper is centrally about endometriosis — it evaluates how endometriosis affects pregnancy outcomes in a Fujian cohort.

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Abstract

OBJECTIVE: Endometriosis is a common gynecological disease, affecting 5 to 10% of women of childbearing age. We analyzed pregnancy complications and neonatal outcomes of patients with pregnancies complicated with endometriosis. The aim of the study was to explore the effects of endometriosis on pregnancy and to evaluate the potential pregnancy risks associated with this disease. PATIENTS AND METHODS: The retrospective study included 3,809 parturients who were routinely examined, hospitalized and underwent cesarean section delivery in Fujian Maternal and Child Health Hospital from January 2014 to December 2020. Among them, 1,026 parturients were diagnosed with endometriosis after the cesarean section (endometriosis group), and 2,783 parturients without endometriosis comprised the control group. The endometriosis group was further divided into subgroups according to the severity of the disease: 882 parturients with stage Ⅰ or Ⅱ of endometriosis, and 144 parturients with stage Ⅲ or Ⅳ of endometriosis. General data of all patients and medical records of pregnancy complications and neonatal outcomes for each group were collected and retrospectively analyzed. RESULTS: There were no statistically significant differences in the age, gestational age, gestation, and parity times between all groups (p>0.05). The incidence of preeclampsia and placenta previa in the endometriosis group was higher than that in the control group (p<0.05). There was no significant difference in rates of other pregnancy complications, such as chronic hypertension with pregnancy, preeclampsia with chronic hypertension, hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome, gestational diabetes mellitus (GDM), pregestational diabetes mellitus (PGDM), intrahepatic cholestasis of pregnancy (ICP), premature rupture of membranes or placental abruption between the two groups. The incidence of placenta previa in the group of patients with stage III/IV endometriosis was higher than in patients with stage I/II endometriosis (p<0.05). However, there was no significant difference in the incidence of other pregnancy complications. The amount of postpartum hemorrhage (1,000-1,500 ml) in the endometriosis group was greater than that in the control group, and the difference was statistically significant (p<0.05). However, there was no significant difference in the incidence of postpartum hemorrhage in patients with pregnancies complicated with endometriosis at different stages. CONCLUSIONS: In pregnant women, endometriosis is associated with an increased incidence of placenta previa that correlates with the severity of the disease. Pregnant women with endometriosis have higher rates of preeclampsia and postpartum hemorrhage, compared to women without endometriosis.
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Objective

Endometriosis is a common gynecological disease, affecting 5 to 10% of women of childbearing age. We analyzed pregnancy complications and neonatal outcomes of patients with pregnancies complicated with endometriosis. The aim of the study was to explore the effects of endometriosis on pregnancy and to evaluate the potential pregnancy risks associated with this disease. PATIENTS AND METHODS: The retrospective study included 3,809 parturients who were routinely examined, hospitalized and underwent cesarean section delivery in Fujian Maternal and Child Health Hospital from January 2014 to December 2020. Among them, 1,026 parturients were diagnosed with endometriosis after the cesarean section (endometriosis group), and 2,783 parturients without endometriosis comprised the control group. The endometriosis group was further divided into subgroups according to the severity of the disease: 882 parturients with stage Ⅰ or Ⅱ of endometriosis, and 144 parturients with stage Ⅲ or Ⅳ of endometriosis. General data of all patients and medical records of pregnancy complications and neonatal outcomes for each group were collected and retrospectively analyzed.

Results

There were no statistically significant differences in the age, gestational age, gestation, and parity times between all groups (p>0.05). The incidence of preeclampsia and placenta previa in the endometriosis group was higher than that in the control group (p<0.05). There was no significant difference in rates of other pregnancy complications, such as chronic hypertension with pregnancy, preeclampsia with chronic hypertension, hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome, gestational diabetes mellitus (GDM), pregestational diabetes mellitus (PGDM), intrahepatic cholestasis of pregnancy (ICP), premature rupture of membranes or placental abruption between the two groups. The incidence of placenta previa in the group of patients with stage III/IV endometriosis was higher than in patients with stage I/II endometriosis (p<0.05). However, there was no significant difference in the incidence of other pregnancy complications. The amount of postpartum hemorrhage (1,000-1,500 ml) in the endometriosis group was greater than that in the control group, and the difference was statistically significant (p<0.05). However, there was no significant difference in the incidence of postpartum hemorrhage in patients with pregnancies complicated with endometriosis at different stages.

Conclusions

In pregnant women, endometriosis is associated with an increased incidence of placenta previa that correlates with the severity of the disease. Pregnant women with endometriosis have higher rates of preeclampsia and postpartum hemorrhage, compared to women without endometriosis. Free PDF DownloadThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License To cite this article Z.-Z. Liu, S.-J. Tang, X. Chen, J.-Y. Wang, Y.-L. Zhang Effects of endometriosis on pregnancy outcomes in Fujian province Eur Rev Med Pharmacol Sci Year: 2023 Vol. 27 - N. 22 Pages: 10968-10978 DOI: 10.26355/eurrev_202311_34465 Publication History Published online: 29 Nov 2023

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Hypertension Hypertension Hypertension Hypertension Hypertension Hypertension Hypertension Placenta Previa Placenta Previa Placenta Previa Placenta Previa Placenta Previa

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