Effect of Curcuma on migration and growth of endometriosis in rat

Objective To investigate the mechanism of the Curcuma treatment to endometriosis.Methods The endometriosis model was established in clean female SD rats.After 3 weeks,the model rats were divided into model,gestrinone and Curcuma groups(n = 10).Rats in sham group were selected as control.After 3 weeks of treatment,the volume of ectopic endometrial was measured.Level of E2 was determined by ELISA.Expressions of ERα,VEGF and MMP-3 were determined by immunostaining.Results There were obvious differences in ectopic tissue volume,E2,ERα,VEGF,MMP-3 between treatment groups and model group.There was no difference between gestrinone and Curcuma groups.Conclusions Curcuma can inhibit the ectopic tissue volume,level of E2,expressions of ERα,VEGF and MMP-3,inhibit ectopic endometrium growth and neovascularity and cure endometriosis.