Significant association of TP53 Arg72Pro polymorphism in susceptibility to differentiated thyroid cancer.

Khan MS, Pandith AA, Masoodi SR, Khan SH, Rather TA, Andrabi KI, Mudassar S
Cancer biomarkers : section A of Disease markers · 2015 · doi:10.3233/cbm-150485 · PMID:25835179 · PMC12965092
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This case-control study found a significant association between the TP53 Arg72Pro polymorphism and increased susceptibility to differentiated thyroid cancer, particularly in young females and non-smokers.

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This case-control study investigated the association between the TP53 Arg72Pro polymorphism and susceptibility to differentiated thyroid cancer among 140 patients and 200 controls from the Kashmir Valley. The researchers utilized PCR-RFLP to analyze genotype distributions and found that the proline allele frequency was significantly higher in the patient group compared to healthy controls. Significant associations were observed between the variant genotype and specific factors including young age, female gender, urban residence, non-smoking status, and elevated TSH levels. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

BackgroundAmong various polymorphic variants of TP53 gene, codon 72 polymorphism (Arg72Pro) has been found to be associated with cancer susceptibility, but only few studies have investigated their effect on thyroid cancer risk.ObjectiveA case control study was conducted to elucidate the possible role of this SNP as risk factor in thyroid cancer development and to examine its correlation with various clinicopathological variables.MethodsIn this study, we tested the genotype distribution by PCR-RFLP in 140 thyroid cancer patients and 200 cancer-free controls from Kashmir Valley.ResultsGenotype frequencies of Arg/Arg (GG), Arg/Pro (GC), and Pro/Pro (CC) genotypes among cases were 0.286, 0.343 and 0.371 while in controls 0.45, 0.37 and 0.18 respectively. Proline allele frequency was significantly higher than arginine frequency in patient group (OR = 2.06, 95% C.I = 1.5-2.8). Significant association was found between variant genotype of codon 72 of TP53 gene and young age group, female gender, urban dwellers, non-smokers and patients with elevated TSH levels (P < 0.05).ConclusionIt is evident from our study that Arg72Pro SNP of TP53 gene is connected with higher susceptibility to thyroid cancer especially in young age group, female gender, non-smokers and patients with elevated TSH levels, hence, implicated in thyroid carcinogenesis.
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Abstract

BACKGROUND: Among various polymorphic variants of TP53 gene, codon 72 polymorphism (Arg72Pro) has been found to be associated with cancer susceptibility, but only few studies have investigated their effect on thyroid cancer risk.

Objective

A case control study was conducted to elucidate the possible role of this SNP as risk factor in thyroid cancer development and to examine its correlation with various clinicopathological variables.

Methods

In this study, we tested the genotype distribution by PCR-RFLP in 140 thyroid cancer patients and 200 cancer-free controls from Kashmir Valley.

Results

Genotype frequencies of Arg/Arg (GG), Arg/Pro (GC), and Pro/Pro (CC) genotypes among cases were 0.286, 0.343 and 0.371 while in controls 0.45, 0.37 and 0.18 respectively. Proline allele frequency was significantly higher than arginine frequency in patient group (OR = 2.06, 95% C.I = 1.5-2.8). Significant association was found between variant genotype of codon 72 of TP53 gene and young age group, female gender, urban dwellers, non-smokers and patients with elevated TSH levels (P < 0.05).

Conclusion

It is evident from our study that Arg72Pro SNP of TP53 gene is connected with higher susceptibility to thyroid cancer especially in young age group, female gender, non-smokers and patients with elevated TSH levels, hence, implicated in thyroid carcinogenesis.

Keywords

Papillary thyroid cancer, thyroid stimulating hormone, benign thyroid disease, differentiated thyroid cancer, polymerase chain reaction, restriction digestion Full Text The Full Text of this article is available as a PDF (108.5 KB).

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