Efficacy of a Tailored COMET Protocol Combined with Medication on Vibratory Perception and SkinConductance in Diabetic Neuropathy- A Protocol for Randomized Controlled Trial

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Participants will be allocated to either the intervention group, which will get the customized COMET protocol and medicine, or the control group, which will receive standard medication alone, in a randomized controlled trial. Validated measurement instruments will be used in the trial to evaluate variations in skin conductance and vibratory perception both at baseline and during the course of the investigation. Strict adherence to ethical rules will guarantee the safety and well-being of participants. This study intends to provide important insights into the holistic management of diabetic neuropathy by examining the effects of the customized COMET protocol in conjunction with medication on vibratory perception and skin conductance. This could result in better treatment plans and an improvement in the quality of life for those who are affected. CTRI Reference Number CTRI/2023/07/055366,https://ctri.nic.in/Clinicaltrials/rmaindet.php?trialid=89691&EncHid=88073.73654&modid=1&compid=19,20/07/2023 " } { "@context": "http://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": "1", "item": { "@id": "https://f1000research.com/", "name": "Home" } }, { "@type": "ListItem", "position": "2", "item": { "@id": "https://f1000research.com/browse/articles", "name": "Browse" } }, { "@type": "ListItem", "position": "3", "item": { "@id": "https://f1000research.com/articles/13-344/v1", "name": "Efficacy of a Tailored COMET Protocol Combined with Medication on..." } } ] } Home Browse Efficacy of a Tailored COMET Protocol Combined with Medication on... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Raghuveer R, Hullumani V S and Irshad Qureshi M. Efficacy of a Tailored COMET Protocol Combined with Medication on Vibratory Perception and SkinConductance in Diabetic Neuropathy- A Protocol for Randomized Controlled Trial [version 1; peer review: 1 approved, 1 not approved] . F1000Research 2024, 13 :344 ( https://doi.org/10.12688/f1000research.144809.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Study Protocol Efficacy of a Tailored COMET Protocol Combined with Medication on Vibratory Perception and SkinConductance in Diabetic Neuropathy- A Protocol for Randomized Controlled Trial [version 1; peer review: 1 approved, 1 not approved] Raghumahanti Raghuveer https://orcid.org/0000-0001-7696-0786 1 , Sharath Hullumani V https://orcid.org/0009-0000-2926-5609 2 , Moh’d Irshad Qureshi 1 Raghumahanti Raghuveer https://orcid.org/0000-0001-7696-0786 1 , Sharath Hullumani V https://orcid.org/0009-0000-2926-5609 2 , Moh’d Irshad Qureshi 1 PUBLISHED 23 Apr 2024 Author details Author details 1 Neurophysiotherapy, Professor, Ravi Nair Physiotherapy College, Datta Meghe Institute of Higher Education and Research (DU), Sawangi Meghe, Wardha, Maharashtra, 442004, India 2 Assistant Professor, Paediatric Physiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute Higher Education and Research (DU), Sawangi Meghe, Wardha, Maharashtra, 442004, India Raghumahanti Raghuveer Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Software, Validation Sharath Hullumani V Roles: Investigation, Software, Writing – Original Draft Preparation, Writing – Review & Editing Moh’d Irshad Qureshi Roles: Conceptualization, Data Curation, Resources, Software, Supervision, Validation, Visualization OPEN PEER REVIEW DETAILS REVIEWER STATUS This article is included in the Datta Meghe Institute of Higher Education and Research collection. Abstract This research attempts to evaluate the effectiveness of a customized COMET protocol in conjunction with medicine for the treatment of diabetic neuropathy, with vibratory perception and skin conductance being the main focus. Participants will be allocated to either the intervention group, which will get the customized COMET protocol and medicine, or the control group, which will receive standard medication alone, in a randomized controlled trial. Validated measurement instruments will be used in the trial to evaluate variations in skin conductance and vibratory perception both at baseline and during the course of the investigation. Strict adherence to ethical rules will guarantee the safety and well-being of participants. This study intends to provide important insights into the holistic management of diabetic neuropathy by examining the effects of the customized COMET protocol in conjunction with medication on vibratory perception and skin conductance. This could result in better treatment plans and an improvement in the quality of life for those who are affected. CTRI Reference Number CTRI/2023/07/055366,https://ctri.nic.in/Clinicaltrials/rmaindet.php?trialid=89691&EncHid=88073.73654&modid=1&compid=19,20/07/2023 READ ALL READ LESS Keywords Diabetic Neuropathy, Foot, Rehabilitation, Skin Conductance, Research Protocol Corresponding Author(s) Sharath Hullumani V ( [email protected] ) Close Corresponding author: Sharath Hullumani V Competing interests: No competing interests were disclosed. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2024 Raghuveer R et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Raghuveer R, Hullumani V S and Irshad Qureshi M. Efficacy of a Tailored COMET Protocol Combined with Medication on Vibratory Perception and SkinConductance in Diabetic Neuropathy- A Protocol for Randomized Controlled Trial [version 1; peer review: 1 approved, 1 not approved] . F1000Research 2024, 13 :344 ( https://doi.org/10.12688/f1000research.144809.1 ) First published: 23 Apr 2024, 13 :344 ( https://doi.org/10.12688/f1000research.144809.1 ) Latest published: 23 Apr 2024, 13 :344 ( https://doi.org/10.12688/f1000research.144809.1 ) Introduction These days, diabetes is thought to be one of the main causes of morbidity and death. 1 The International Diabetes Federation has released updated statistics showing that 463 million people worldwide have diabetes and 374 million are at risk of becoming type 2 diabetes mellitus (T2DM). 2 In India, the number of individuals with diabetes is expected to increase from approximately 77 million in 2019 to 134.2 million by 2045. 2 Numerous issues, such as microvascular and macrovascular consequences, are brought on by diabetes. 3 – 5 Diabetic neuropathy is the most prevalent and alarming consequence of diabetes mellitus (DM). Peripheral, focal, proximal, or autonomic can all be described. Over 40 million diabetics worldwide suffer from neuropathy. 6 Diabetic peripheral neuropathy (DPN) is defined by the American Diabetes Association (ADA) as “the presence of symptoms and/or signs of peripheral nerve dysfunction in people with diabetes after the exclusion of other causes. 7 It affects particular nerve system regions 8 causing morbidity and raising the cost of diabetic care. 9 Up to 50% of instances of this long-term diabetic consequence are asymptomatic. 10 , 11 Additionally, 40–60% of amputations of the lower extremities are caused by it. 12 DPN symptoms might be silent and go unnoticed, or they can be subjective and transient, 13 resembling symptoms of other illnesses. It may result in extremely painful symptoms or loss of feeling. 14 Consequently, the preferred technique for diagnosing peripheral neuropathy is clinical examination. 15 Significant abnormalities in touch and pain sensitivity, kinaesthesia, lower-limb proprioception, and vibration sense are common symptoms of diabetic peripheral neuropathy (DPN), which is brought on by the stimulation of neuronal death and restriction of nerve regeneration. 16 Sensory alterations in the “glove-and-stocking” distribution are the primary indicator of it. 17 We don’t know the actual prevalence of DPN. According to studies, the percentage of diabetes patients with neuropathy can range from 10% to 90%, depending on the definition and techniques employed. In surveys of Indian patients, DPN has been reported in 26–31% of cases. 18 DPN is difficult to treat, and there are few medications available. Tricyclic antidepressants, opioids, gabapentin, pregabalin, serotonin and norepinephrine reuptake inhibitors, and gabapentin are common therapy drugs. 19 Frequent exercise lowers body weight enhances insulin sensitivity and blood glucose control, and lowers the risk of neuropathy in diabetic individuals. The standard treatment for obesity and diabetes mellitus involves nutrition and increased physical activity. 20 Research suggests that those with type 1 diabetes are more likely than those with other types of diabetes to exercise. The data demonstrates that practice interventions can enhance diabetes control. The majority of research have shown that it is beneficial to carry out training treatments between 8 weeks and 12 months for diabetes patients who have a peripheral neuropathy risk factor for diabetic foot ulcers. Significant increases in physical activity have been observed in several investigations, without a corresponding rise in injury risk. If health care is incomplete, foot ulcers may develop, which is the most common cause of hospitalization and amputation. 21 Usually, the combination of various treatments, including pharmacotherapy, physiotherapy, and orthotic devices are used to maintain biomechanical parameters, physiological patterns, and at last, for wound healing. 22 Insulin therapy, including pharmacotherapy and lifestyle interventions, is considered a conventional treatment for preventing diabetes complaints. 23 Objectives The objectives of the present study are: 1. To determine the effectiveness of a comprehensive COMET Protocol when given along with medication on vibratory perception in subjects with Diabetic Polyneuropathy. 2. To determine the effectiveness of a comprehensive COMET Protocol when given along with medication on skin conductance in subjects with Diabetic Polyneuropathy. 3. To determine the effectiveness of a comprehensive COMET Protocol when given along with medication on the Quality of Life in subjects with Diabetic Polyneuropathy. Protocol This protocol has been registered with CTRI and Reg No. CTRI/2023/07/055366, https://ctri.nic.in/Clinicaltrials/rmaindet.php?trialid=89691&EncHid=88073.73654&modid=1&compid=19 Date: 20/07/2023. Ethics and consent This study will be conducted with written informed consent from all participants. Ethical approval was received from the Datta Meghe Institute of Higher Education and Research (DU). IEC:DMIHER Date of approval: July 7th 2023 institutional ethics committee REF/2023/07/070102. Trial design It is a two-arm parallel group, equal allocation superiority trial. This study will be conducted with written informed consent from all participants. Participants will be chosen from inpatient and outpatients from Neurophysiotherapy Outpatient Department, AVBRH, Sawangi, Meghe, Wardha, Maharashtra, following acceptance from the institutional ethics committee of DMIHER. Once given consent and assent, these participants will be divided into two groups by simple random sampling method and allocation will be done through Sequentially Numbered Opaque Sealed Envelope (SNOSE) method into the Experimental group and Control group. The experimental group will be receiving COMET protocol for one hour each day, 6 days per week for 4 weeks. The participants of this group will continue with their diabetic neuropathy medication along with physiotherapy. The control group will be receiving their medication for diabetic polyneuropathy and general exercises will be taught which the participants will be continuing for a month. Inclusion criteria 1. Those who were aged more than 30 years and diagnosed positive for type 2 diabetes for at least 1-year duration with random blood sugar >200 mg/dL or fasting blood sugar >126 mg/dL as per the Indian Council of Medical Research guidelines 2005. 2. MNSI score ≥ 7 for History and ≥ 2.5 for Examination. Exclusion criteria 1. Patients with Gestational Diabetes 2. Patients diagnosed with Type-1 DM 3. Patients with foot ulcers 4. Patients who underwent amputation following DPN. 5. History of surgical procedures secondary to DPN 6. Patients with a history of Joint degenerative diseases 7. Subjects falling under the absolute contraindication category for physiotherapy. Participant timeline Data will be collected on the baseline as pre and post-data, followed by intervention for 4 weeks and post-intervention data on the last day of the 4 th week is again recorded, CONSORT Flow chart is mentioned in Figure 1 . Figure 1. CONSORT flow chart. Group A: The experimental group will be receiving COMET protocol ( Table 1 ), the Acronym 1. CO ntrast Bath 2. M obility - Nerve Mobilization & Mobility Exercises 3. E -Stim - Plantar Electrical Stimulation 4. T herapeutic Foot Massage Table 1. COMET protocol. S. No. Intervention Procedure Dosage 1. Contrast Bath Application of Hot & Cold Immersion: 1. Position of the Patient: The patient is comfortably placed in a seated position on a chair with back support. The height of the chair must be sufficient to position the hips and knees at 90 o . 2. Instructions to the Patient: The patient is instructed to be as relaxed as possible and inform the therapist at once in case of any discomfort. 3. Procedure: i. The contrast bath is applied either by a Contrast Bath Modality (CBM) or by using a bucket filled with warm or cold water sufficient to immerse the patient’s foot. ii. A thermometer is used to record the water temperature throughout the intervention and a clock to measure the time duration. iii. The patient is instructed to place his foot (one at a time) in the CBM/Bucket filled with warm water between 37 o -43 o for a duration of 4 minutes. iv. After 4 minutes, the leg is lifted from the bucket and at once placed in a CBM/Bucket filled with cold water between 12 o -15 o for a duration of 1 minute. v. This process of alternating between warm water and cold water is repeated 4 times for a total duration of 20 minutes. 4. Winding up of the procedure : Once the total immersion time of 20 minutes is complete, the patient is instructed to lift his leg from the bucket, and the skin is dried with a soft towel. The process is repeated for the contralateral foot. 20 minutes per session, 6 sessions per week for 4 weeks 2. Nerve Mobilization Application of Nerve Mobilization to Posterior Tibial and Peroneal nerve. 1. Position of the Patient: The patient is positioned in a relaxed supine lying position without any pillow under the head. 2. Instructions to the Patient: The patient is instructed to be as relaxed as possible and inform the therapist at once in case of any discomfort. 3. Nerve mobilization for Peroneal Nerve: Application of Proximal and Distal Sliders: i. With the patient in a supine, and the therapist in a walk stance on the side being treated, the therapist elevates the hip to 45 o and the knee slightly flexed to allow the leg to be positioned horizontally. ii. The therapist faces towards the foot and holds the knee between his forearm and trunk. The therapist's upper limb nearer to the patient will support the leg. iii. The volar aspect of the therapist's forearm will be in contact with the posteromedial aspect of the patient's leg supporting it. iv. The farther upper limb of the therapist places his palm on the dorsolateral aspect of the patient's forefoot such that the fingers overlap the toes, and the thumb is towards the dorso- medial surface. v. For the proximal slider, the therapist extends the knee on the flexed hip with the foot drawn into dorsiflexion and eversion. vi. For the distal slider, the therapist flexes the knee up to 90 o on the flexed hip with the foot drawn into plantarflexion and inversion. 4. Nerve mobilization for Posterior Tibial Nerve: Application of Proximal and Distal Sliders: i. With the patient in a supine, and the therapist in a walk stance on the side being treated, the therapist elevates the hip to 45 o and the knee slightly flexed to allow the leg to be positioned horizontally. ii. The therapist faces towards the foot and holds the knee between his forearm and trunk. The therapist's upper limb nearer to the patient will support the leg. iii. The volar aspect of the therapist's forearm will be in contact with the posteromedial aspect of the patient's leg and the therapist's hand will caress the calcaneum of the patient. iv. For the proximal slider, the therapist dorsiflexes the heel with his proximal hand by pushing it forward and dorsiflexes the forefoot and toes drawing them into eversion with his distal hand. This is done till resistance is encountered or symptoms elicited. v. This is followed by slowly extending the knee until further range is impossible or there is discomfort. vi. At this position, the pressure of dorsiflexion and eversion is slowly released with the knee still in the previous extended position. This will allow the nerve to migrate proximally. vii. For the distal slider, the therapist elevates the hip to 45 o and the knee slightly flexed to allow the leg to be positioned horizontally. viii. The therapist dorsiflexes the heel with his proximal hand by pushing it forward and dorsiflexes the forefoot and toes drawing them into eversion with his distal hand. This is done till resistance is encountered or symptoms elicited. Once a good response becomes consistent, each movement can be performed in four or five sets of 5-30 repetitions per set (maximum of 25-150 repetitions depending on the severity of symptoms and response). Breaks of approximately 10 seconds to several minutes between sets can be given according to the patient outcome. Total Treatment time between 10-15 minutes per session, 3 sessions per week for 4 weeks. 3. Mobility Exercise Application of an Aerobic Mobility Exercise: The patient will be instructed to enrol in a walking program initiating with 5 minutes of normal walking for warm-up, followed by 40 minutes of brisk walking at their favourable pace, and ending with 5 minutes of normal walking for cool down. Total of 50 minutes per day, 300 minutes per week for 4 weeks 4. Plantar Electrical Stimulation Application of Transcutaneous Electrical Nerve Stimulation on the plantar surface of the foot: 1. Position of the Patient: The patient is comfortably placed in a supine position with a pillow under the knee. 2. Instructions to the Patient: The patient is instructed to be as relaxed as possible and is informed that he will feel mild tingling in the sole where the electrode is placed. The patient is also instructed to inform the therapist immediately in case of discomfort. 3. Procedure : i. The skin on the plantar surface of both feet is cleansed with cotton dipped in tap water and dried. ii. A two-channel TENS machine is used with each channel of paired electrodes applied on each foot. iii. The self-sticking adhesive electrodes are used, and each pair are placed with one electrode over the metatarsal heads in the middle of the forefoot and the other over the attachment of the plantar fascia in the middle of the junction between the mid-foot and hind foot. iv. The machine is switched on, and the intensity is gradually increased till the patient informs a comfortable tingling sensation under the electrodes. v. The intensity is maintained at this level and the foot is stimulated for a duration of 20 minutes. 4. Winding up of the procedure : Once the total stimulation time of 20 minutes is complete, the machine is switched off, the electrodes are removed, and the skin is inspected for any changes. If no changes are found, the skin is cleansed again with cotton dipped in tap water and dried. The patient is instructed to get up from a lying position whenever he/she is comfortable. 20 min at 80Hz, 60μs pulse duration. Comfortable tingling, 3 times per week for 4 weeks 5. Therapeutic Foot Massage Application of Therapeutic Foot Massage Techniques: 1. Position of the Patient: The patient is comfortably placed in the prone position and the lower limb is exposed up to the inferior gluteal region. 2. Instruction to the patient: The patient is instructed to be relaxed as much as possible and inform the therapist at once in case of any discomfort. 3. The procedure of Massage: i. Massaging gel or coconut oil is used for massaging as it helps in moisturizing and lubrication. ii. The massage begins with touching the heel of the foot to initiate contact. iii. Effleurage strokes are used from the heel to the entire leg 3-5 times to spread the lubricant and warm the tissues. iv. Petrissage manipulation including horizontal and vertical thumb and finger kneading, and static pressure are applied to the bottom of the feet starting with the base of the middle toe, moving one thumb width up towards the center of the foot, moving up towards the heel, spreading down towards the mid arches of the foot and ending at the base of the first and fifth toes. v. These are followed by effleurage strokes 3-5 times toward the popliteal lymph nodes. vi. Using both hands, hold the calcaneum between the thenar and hypothenar muscles and apply compression and distraction at the talocalcaneal joint. vii. This is followed by contacting the Achilles tendon by the ulnar side of both hands caressing it and sliding back and forth. viii. The calf muscle is reached with hands still in contact with the skin, and petrissage manipulations including thumb kneading, finger kneading, wringing, and picking up are applied to the calf muscles from distal to proximal till the knee joint line. ix. Thumb kneading is done to the tender areas of the calf muscle between the heel and the knee joint. x. These manipulations are ended by effleuraging the entire foot, leg, and thigh 3-5 times. 4. Winding of the Procedure : After completion of the massage, the patient is instructed to lie for a few minutes and get up whenever he/she is comfortable. 10-15 minutes per session, 3 times per week for 4 weeks Group B The control group will be receiving their medication for diabetic polyneuropathy and general exercises will be taught which the participants will be continuing for a month. Outcomes A. Vibratory Perception Threshold (VPT): it is an instrument which is used to measure the vibratory perception threshold. B. Galvanic Skin Conductance (GSC): It is an instrument which is used to measure the level of conductance across the skin. C. Michigan Neuropathy Screening Instrument (MNSI): An instrument to screen and diagnose diabetic patients with neuropathy. D. NeuroQoL questionnaire (NQOL): It is a specific validated neuropathy and foot ulcer QoL instrument which assesses diabetic neuropathy-related physical and emotional problems affecting daily life and well-being. Sample size calculation N = ( Z ( α / 2 ) + Z β ) 2 ( P 1 ( 1 − P 1 ) + ( P 2 ( 1 − P 2 ) ) 2 ( P 2 − P 1 ) 2 ) Z α / 2 = at 95 % ( CI ) = 1.96 Represents the desired level of statistical significance Z β = 0.84 Represents the desired power = 0.80 for 80% N = Minimum samples required for each group Primary Variable = Perception of vibration sensitivity Where, % of improvement in Perception of vibration sensitivity (Pre) in control group = P1 = (79.31%- 75.86%) = 3.45% (As per ref. article Krishna Dalal et al., Determination of efficacy of reflexology in managing patients with Diabetic Neuropathy; A Randomised Controlled Trial). Considering 20% significant margin superiority of improvement for interventional group (comet protocol) = 23.45% Minimum sample size required N = ( 1.96 + 0.84 ) 2 ( ( 0.0345 ) ∗ ( 1 − 0.0345 ) + ( 0.2345 ) ∗ ( 1 − 0.2345 ) ) 2 / ( 0.20 ) 2 = 45 Per group Considering 10% drop out = 45 per group Total samples required = 45 + 5 = 50 per group. Safety outcomes Adverse events will be reported at each time. No adverse effects are anticipated. Methods Data collection methods : The assessment and collection of outcomes will be done in the preintervention stage after assigning them to the intervention groups. Post- intervention data will be collected on the same day. This will be followed by the collection of post-intervention data after the completion of 4 weeks of intervention. Data management: The collected information will be summarized by using frequency percentage for qualitative data and mean and standard deviation for quantitative data. Statistical methods: To find the effectiveness of COMET Protocol along with medication on Vibratory Perception Threshold (VPT), Galvanic Skin Conductance (GSC), Michigan Neuropathy Screening Instrument (MNSI) and NeuroQOL in subjects with Diabetic Polyneuropathy, paired t-test will be used for within-group comparison and unpaired t-test will be used for between-group comparisons. If the data is not following a normal distribution, the Wilcoxon sign rank test will be used for within-group comparisons and the Mann-Whitney U test will be used for between- group comparisons. A “p” value less than 0.05 will be considered significant. Outcome measures will be evaluated by using SPSS 21 software version. Methods: Monitoring Data monitoring: The data will be monitored by the Data Monitoring Committee of Ravi Nair Physiotherapy College. Harms Any episode of the adverse events shall be reported to the Ethical Committee and the clinician in charge for assessing and managing the solicited and spontaneous adverse events and other unintended effects of trial interventions or trial conduct. Ethics and dissemination Consent and assent: Participants who will be enrolled in the study will be made aware of the study and informed consent and assent will be obtained from each one of them. Confidentiality: Any information pertaining to the subjects participating in the study shall be maintained confidential. Any patient-related information will only be used with due permission from the subjects. Declaration of interests: There are no financial or competing interests to mention. Access to data : All the data collected during or after the study shall be stored and maintained by the study’s Principal Investigator. The PI will have access to the final trial dataset, and it will be shared with de-identification after receiving a formal request for research and publication purposes only. Ancillary and post-trial care: Care shall be provided to the study subjects in case of events leading to harm from trial participation by the PI in accordance with the policy of Ravi Nair Physiotherapy College and DMIHER. Dissemination policy: Any data collected during or after the study will only be used for academic and research-related purposes culminating in a publication in a reputed journal and to present in international or national journal. Discussion With a specific focus on vibratory perception and skin conductance as primary outcome measures, this proposed randomized controlled trial seeks to assess the effectiveness of a customized COMET protocol in conjunction with medication for the management of diabetic neuropathy. A thorough evaluation of participants’ baseline skin conductance and vibratory perception will be part of the procedure. After that, participants will be randomly assigned to either the intervention group, which will get the customized COMET protocol and the control group, which will receive standard medication alone. Using established measurement instruments, researchers will closely monitor changes in skin conductance and vibratory perception throughout the experiment to provide quantitative evidence on the efficacy of the combined intervention approach. The research will comply with strict ethical standards and give top priority to participant safety, guaranteeing that every participant will receive the necessary attention and supervision throughout the study. This trial has the potential to offer important insights into the comprehensive management of diabetic neuropathy by examining the effects of the customized COMET protocol in conjunction with medication on vibratory perception and skin conductance. Ultimately, this could improve the quality of life for those who suffer from this difficult condition. This study protocol aims to produce credible evidence on the efficacy of the customized COMET protocol combined with medication in addressing vibratory perception and skin conductance in diabetic neuropathy through the use of a robust randomized controlled trial design and standardized assessment tools. The study will carefully gather and examine data pertaining to alterations in these physiological parameters, allowing for a thorough assessment of the influence of the intervention on peripheral nerve function and autonomic nervous system activity. The trial design places a strong emphasis on participant welfare and ethical considerations, making sure that participants receive the proper assistance and oversight during the study. Through a more thorough comprehension of the possible advantages of the customized COMET protocol when combined with medication, this study could influence clinical practice and help create efficient, individualized treatment plans for people with diabetic neuropathy, ultimately improving their general health and well-being. Ethics and consent This study will be conducted with written informed consent from all participants. Ethical approval was received from the Datta Meghe Institute of Higher Education and Research (DU)IEC:DMIHER Date of approval: July 7th 2023 institutional ethics committee REF/2023/07/070102. Data availability Underlying data No data were associated with this article. Reporting guidelines Zenodo: Spirit Checklist for Efficacy of a Tailored COMET Protocol Combined with Medication on Vibratory Perception and SkinConductance in Diabetic Neuropathy - A Protocol for Randomized Controlled Trial, DOI https://doi.org/10.5281/zenodo.10076923 Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0). Acknowledgement We would like to acknowledge Mr. Laxmikant Umate Sir, who has helped us in sample size calculation and data analysis planning. References 1. Zychowska M, Rojewska E, Przewlocka B, et al. : Mechanisms and pharmacology of diabetic neuropathy - experimental and clinical studies. Pharmacol. Rep. 2013; 65 (6): 1601–1610. PubMed Abstract | Publisher Full Text 2. Collins SL, Moore RA, McQuayHJ WP: Antidepressants and anticonvulsants for diabetic neuropathy and postherpetic neuralgia: a quantitative systematic review. J. Pain Symptom Manag. 2000 Dec; 20 (6): 449–458. PubMed Abstract | Publisher Full Text 3. Hussain S, Habib A, Najmi AK: Anemia prevalence and its impact on health-related quality of life in Indian diabetic kidney disease patients: Evidence from a cross-sectional study. J. Evid. Based Med. 2019 Nov; 12 (4): 243–252. PubMed Abstract | Publisher Full Text 4. Gheith O, Farouk N, Nampoory N, et al. : Diabetic kidney disease: world wide difference of prevalence and risk factors. J. Nephropharmacol. 2015 Oct 9; 5 (1): 49–56. PubMed Abstract | Free Full Text 5. Abbott CA, Malik RA, van Ross ER , et al. : Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K. Diabetes Care. 2011 Oct; 34 (10): 2220–2224. PubMed Abstract | Publisher Full Text | Free Full Text 6. Pop-Busui R, Boulton AJ, Feldman EL, et al. : Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Diabetes Care. 2017 Jan; 40 (1): 136–154. PubMed Abstract | Publisher Full Text | Free Full Text 7. Vinik AI, Nevoret ML, Casellini C, et al. : Diabetic neuropathy. Endocrinol. Metab. Clin. N. Am. 2013 Dec; 42 (4): 747–787. PubMed Abstract | Publisher Full Text 8. Dyck PJ, Kratz KM, Karnes JL, et al. : The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study. Neurology. 1993 Apr; 43 (4): 817–824. Erratum in: Neurology 1993 Nov;43(11):2345. PubMed Abstract | Publisher Full Text 9. Aslam A, Singh J, Rajbhandari S: Pathogenesis of painful diabetic neuropathy. Pain Res. Treat. 2014; 2014 : 412041. Epub 2014 May 6. PubMed Abstract | Publisher Full Text | Free Full Text 10. Consensus statement: Report and recommendations of the San Antonio conference on diabetic neuropathy. American Diabetes Association American Academy of Neurology. Diabetes Care. 1988 Jul-Aug; 11 (7): 592–597. PubMed Abstract | Publisher Full Text 11. Baxi H, Habib A, Hussain MS, et al. : Prevalence of peripheral neuropathy and associated pain in patients with diabetes mellitus: Evidence from a cross-sectional study. J. Diabetes Metab. Disord. 2020 Jul 31; 19 (2): 1011–1017. PubMed Abstract | Publisher Full Text | Free Full Text 12. Dros J, Wewerinke A, Bindels PJ, et al. : Accuracy of monofilament testing to diagnose peripheral neuropathy: a systematic review. Ann. Fam. Med. 2009 Nov-Dec; 7 (6): 555–558. PubMed Abstract | Publisher Full Text | Free Full Text 13. Yang Z, Chen R, Zhang Y, et al. : Scoring systems to screen for diabetic peripheral neuropathy. Cochrane Database Syst. Rev. 2018 Jul 30; 2018 (7): CD010974. Publisher Full Text | Free Full Text 14. Bansal V, Kalita J, Misra UK: Diabetic neuropathy. Postgrad. Med. J. 2006 Feb; 82 (964): 95–100. PubMed Abstract | Publisher Full Text | Free Full Text 15. Yoo M, D’Silva LJ, Martin K, et al. : Pilot Study of Exercise Therapy on Painful Diabetic Peripheral Neuropathy. Pain Med. 2015 Aug; 16 (8): 1482–9. Epub 2015 Mar 20. PubMed Abstract | Publisher Full Text | Free Full Text 16. Paul UK, Sinharay K, Bhattacharyya AK, et al. : Update in diabetic neuropathy with special reference to Indian scenario. J. Indian Med. Assoc. 2012 Sep; 110 (9): 616–622. PubMed Abstract 17. Francia P, Gulisano M, Anichini R, et al. : Diabetic foot and exercise therapy: step by step the role of rigid posture and biomechanics treatment. Curr. Diabetes Rev. 2014 Mar; 10 (2): 86–99. PubMed Abstract | Publisher Full Text | Free Full Text 18. Crews RT, Schneider KL, Yalla SV, et al. : Physiological and psychological challenges of increasing physical activity and exercise in patients at risk of diabetic foot ulcers: a critical review. Diabetes Metab. Res. Rev. 2016 Nov; 32 (8): 791–804. PubMed Abstract | Publisher Full Text | Free Full Text 19. Barbosa AP, Medina JL, Ramos EP, et al. : Prevalence and risk factors of clinical diabetic polyneuropathy in a Portuguese primary health care population. Diabetes Metab. 2001 Sep; 27 (4 Pt 1): 496–502. PubMed Abstract 20. Sartor CD, Watari R, Pássaro AC, et al. : Effects of a combined strengthening, stretching and functional training program versus usual-care on gait biomechanics and foot function for diabetic neuropathy: a randomized controlled trial. BMC Musculoskelet. Disord. 2012 Mar 19; 13 : 36. PubMed Abstract | Publisher Full Text | Free Full Text 21. Dalal K, Maran VB, Pandey RM, et al. : Determination of efficacy of reflexology in managing patients with diabetic neuropathy: a randomized controlled clinical trial. Evid. Based Complement. Alternat. Med. 2014; 2014 : 843036. Epub 2014 Jan 9. PubMed Abstract | Publisher Full Text | Free Full Text 22. Bird SJ, Brown MJ, Spino C, et al. : Value of repeated measures of nerve conduction and quantitative sensory testing in a diabetic neuropathy trial. Muscle Nerve. 2006 Aug; 34 (2): 214–224. PubMed Abstract | Publisher Full Text 23. Gao M, Yun X, Zhang T: VSA-3000: A Quantitative Vibration Sensation Testing Device for Patients With Central Nervous System Injury. Front. Neurol. 2020 Sep 8; 11 : 936. PubMed Abstract | Publisher Full Text | Free Full Text Comments on this article Comments (0) Version 1 VERSION 1 PUBLISHED 23 Apr 2024 ADD YOUR COMMENT Comment Author details Author details 1 Neurophysiotherapy, Professor, Ravi Nair Physiotherapy College, Datta Meghe Institute of Higher Education and Research (DU), Sawangi Meghe, Wardha, Maharashtra, 442004, India 2 Assistant Professor, Paediatric Physiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute Higher Education and Research (DU), Sawangi Meghe, Wardha, Maharashtra, 442004, India Raghumahanti Raghuveer Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Software, Validation Sharath Hullumani V Roles: Investigation, Software, Writing – Original Draft Preparation, Writing – Review & Editing Moh’d Irshad Qureshi Roles: Conceptualization, Data Curation, Resources, Software, Supervision, Validation, Visualization Competing interests No competing interests were disclosed. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (1) version 1 Published: 23 Apr 2024, 13:344 https://doi.org/10.12688/f1000research.144809.1 Copyright © 2024 Raghuveer R et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Raghuveer R, Hullumani V S and Irshad Qureshi M. Efficacy of a Tailored COMET Protocol Combined with Medication on Vibratory Perception and SkinConductance in Diabetic Neuropathy- A Protocol for Randomized Controlled Trial [version 1; peer review: 1 approved, 1 not approved] . F1000Research 2024, 13 :344 ( https://doi.org/10.12688/f1000research.144809.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 1 VERSION 1 PUBLISHED 23 Apr 2024 Views 0 Cite How to cite this report: Abraham MM. Reviewer Report For: Efficacy of a Tailored COMET Protocol Combined with Medication on Vibratory Perception and SkinConductance in Diabetic Neuropathy- A Protocol for Randomized Controlled Trial [version 1; peer review: 1 approved, 1 not approved] . F1000Research 2024, 13 :344 ( https://doi.org/10.5256/f1000research.158656.r300800 ) The direct URL for this report is: https://f1000research.com/articles/13-344/v1#referee-response-300800 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 16 Sep 2024 Manoj Manoharlal Abraham , KG College of Physiotherapy, Coimbatore, Tamil Nadu, India Approved VIEWS 0 https://doi.org/10.5256/f1000research.158656.r300800 1. Wonderful work done by the authors. Yet in the Introduction, there is no content about the Comprehensive COMET Protocol. Because only one part of the COMET, ie., mobility or exercises were explained, but not the other components. Also the ... Continue reading READ ALL 1. Wonderful work done by the authors. Yet in the Introduction, there is no content about the Comprehensive COMET Protocol. Because only one part of the COMET, ie., mobility or exercises were explained, but not the other components. Also the importance of assessing Vibratory Perception, Skin conduction was not clearly mentioned. 2. More of inclusion criteria could be added which would improve the precision effect of the procedures. History on Diabets onset and duration could have been added. 3. Regarding the Protocol, I have a query on duration, as it is mentioned one hour per day, and the protocol has so many things to do. Like Contrast bath, Mobility (which included both Nerve mobilization and mobility exercises – be precise with technique), E-stim and Therapeutic foot massage. The split up which was given in the table 1, was not match with the total duration of one hour. 4. Can be accepted for indexing after it is completely done and making the availability of the data sets, as it is mentioned in the article as No data were associated. Is the rationale for, and objectives of, the study clearly described? Yes Is the study design appropriate for the research question? Yes Are sufficient details of the methods provided to allow replication by others? Yes Are the datasets clearly presented in a useable and accessible format? Partly Competing Interests: No competing interests were disclosed. Reviewer Expertise: Exercise Sciences, Physiotherapy, Orthopedics, Diabetes, Manual therapy, Sports injuries, I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Abraham MM. Reviewer Report For: Efficacy of a Tailored COMET Protocol Combined with Medication on Vibratory Perception and SkinConductance in Diabetic Neuropathy- A Protocol for Randomized Controlled Trial [version 1; peer review: 1 approved, 1 not approved] . F1000Research 2024, 13 :344 ( https://doi.org/10.5256/f1000research.158656.r300800 ) The direct URL for this report is: https://f1000research.com/articles/13-344/v1#referee-response-300800 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Yusuf S. Reviewer Report For: Efficacy of a Tailored COMET Protocol Combined with Medication on Vibratory Perception and SkinConductance in Diabetic Neuropathy- A Protocol for Randomized Controlled Trial [version 1; peer review: 1 approved, 1 not approved] . F1000Research 2024, 13 :344 ( https://doi.org/10.5256/f1000research.158656.r300797 ) The direct URL for this report is: https://f1000research.com/articles/13-344/v1#referee-response-300797 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 29 Jul 2024 Saldy Yusuf , Faculty of Nursing, Hasanuddin University, Makassar, South Sulawesi, Indonesia Not Approved VIEWS 0 https://doi.org/10.5256/f1000research.158656.r300797 Dear Authors The protocol is interesting, with aim to evaluate the effectiveness of COMET again three different intervention, however we note some issue need to clarify. First, the urgency and novelty of current study ... Continue reading READ ALL Dear Authors The protocol is interesting, with aim to evaluate the effectiveness of COMET again three different intervention, however we note some issue need to clarify. First, the urgency and novelty of current study unclear. In the last paragraph of introduction, authors fail to explain research problems. There is missing explanation from problems to research question and study aims. Authors uses following sentences: 1. Frequent exercise lowers body weight enhances insulin sensitivity...... 2. Type 1 diabetes more likely than those .....to exercise... 3. Significant increases in physical activity.... Three aforementioned premises seems that authors tend to introduce effect of exercise, with totally different with study aims (medication, not exercise). Protocol: No information what is Comprehensive COMET protocol, whats different with others COMET study? Trial Design Intervention group: Medication + Physiotherapy Control group: Medication + General exercise Its unclear for reader, what is the content both Physiotherapy and general exercise. Please give brief explanation and justification, why experiments conducted one hour a day for four weeks? give relevant citation. Inclusion Criteria MNSI is a complex assessment, who performed MNSI assessment, what is their competence? Group A COMET Protocol, again is unclear, what is the consideration giving COMET intervention (Contracts Bath, Nerve mobilization and mobility exercise, Plantar electrical simulation, and therapeutic foot massage). The COMET is mismatch with Trial Design, and Study Aim. Group B authors use NQOL, but in inclusion criteria authors uses MNSI. In study aim, QoL is the 3rd study aim, but is unclear why QoL only evaluate in control group solely. Is the rationale for, and objectives of, the study clearly described? Partly Is the study design appropriate for the research question? Partly Are sufficient details of the methods provided to allow replication by others? Partly Are the datasets clearly presented in a useable and accessible format? Not applicable Competing Interests: No competing interests were disclosed. Reviewer Expertise: diabetic foot care I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Yusuf S. Reviewer Report For: Efficacy of a Tailored COMET Protocol Combined with Medication on Vibratory Perception and SkinConductance in Diabetic Neuropathy- A Protocol for Randomized Controlled Trial [version 1; peer review: 1 approved, 1 not approved] . F1000Research 2024, 13 :344 ( https://doi.org/10.5256/f1000research.158656.r300797 ) The direct URL for this report is: https://f1000research.com/articles/13-344/v1#referee-response-300797 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Comments on this article Comments (0) Version 1 VERSION 1 PUBLISHED 23 Apr 2024 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 Version 1 23 Apr 24 read read Saldy Yusuf , Hasanuddin University, Makassar, Indonesia Manoj Manoharlal Abraham , KG College of Physiotherapy, Coimbatore, India Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Abraham M. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 16 Sep 2024 | for Version 1 Manoj Manoharlal Abraham , KG College of Physiotherapy, Coimbatore, Tamil Nadu, India 0 Views copyright © 2024 Abraham M. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions 1. Wonderful work done by the authors. Yet in the Introduction, there is no content about the Comprehensive COMET Protocol. Because only one part of the COMET, ie., mobility or exercises were explained, but not the other components. Also the importance of assessing Vibratory Perception, Skin conduction was not clearly mentioned. 2. More of inclusion criteria could be added which would improve the precision effect of the procedures. History on Diabets onset and duration could have been added. 3. Regarding the Protocol, I have a query on duration, as it is mentioned one hour per day, and the protocol has so many things to do. Like Contrast bath, Mobility (which included both Nerve mobilization and mobility exercises – be precise with technique), E-stim and Therapeutic foot massage. The split up which was given in the table 1, was not match with the total duration of one hour. 4. Can be accepted for indexing after it is completely done and making the availability of the data sets, as it is mentioned in the article as No data were associated. Is the rationale for, and objectives of, the study clearly described? Yes Is the study design appropriate for the research question? Yes Are sufficient details of the methods provided to allow replication by others? Yes Are the datasets clearly presented in a useable and accessible format? Partly Competing Interests No competing interests were disclosed. Reviewer Expertise Exercise Sciences, Physiotherapy, Orthopedics, Diabetes, Manual therapy, Sports injuries, I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Abraham MM. Peer Review Report For: Efficacy of a Tailored COMET Protocol Combined with Medication on Vibratory Perception and SkinConductance in Diabetic Neuropathy- A Protocol for Randomized Controlled Trial [version 1; peer review: 1 approved, 1 not approved] . F1000Research 2024, 13 :344 ( https://doi.org/10.5256/f1000research.158656.r300800) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/13-344/v1#referee-response-300800 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Yusuf S. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 29 Jul 2024 | for Version 1 Saldy Yusuf , Faculty of Nursing, Hasanuddin University, Makassar, South Sulawesi, Indonesia 0 Views copyright © 2024 Yusuf S. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Not Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Dear Authors The protocol is interesting, with aim to evaluate the effectiveness of COMET again three different intervention, however we note some issue need to clarify. First, the urgency and novelty of current study unclear. In the last paragraph of introduction, authors fail to explain research problems. There is missing explanation from problems to research question and study aims. Authors uses following sentences: 1. Frequent exercise lowers body weight enhances insulin sensitivity...... 2. Type 1 diabetes more likely than those .....to exercise... 3. Significant increases in physical activity.... Three aforementioned premises seems that authors tend to introduce effect of exercise, with totally different with study aims (medication, not exercise). Protocol: No information what is Comprehensive COMET protocol, whats different with others COMET study? Trial Design Intervention group: Medication + Physiotherapy Control group: Medication + General exercise Its unclear for reader, what is the content both Physiotherapy and general exercise. Please give brief explanation and justification, why experiments conducted one hour a day for four weeks? give relevant citation. Inclusion Criteria MNSI is a complex assessment, who performed MNSI assessment, what is their competence? Group A COMET Protocol, again is unclear, what is the consideration giving COMET intervention (Contracts Bath, Nerve mobilization and mobility exercise, Plantar electrical simulation, and therapeutic foot massage). The COMET is mismatch with Trial Design, and Study Aim. Group B authors use NQOL, but in inclusion criteria authors uses MNSI. In study aim, QoL is the 3rd study aim, but is unclear why QoL only evaluate in control group solely. Is the rationale for, and objectives of, the study clearly described? Partly Is the study design appropriate for the research question? Partly Are sufficient details of the methods provided to allow replication by others? Partly Are the datasets clearly presented in a useable and accessible format? Not applicable Competing Interests No competing interests were disclosed. Reviewer Expertise diabetic foot care I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. reply Respond to this report Responses (0) Yusuf S. Peer Review Report For: Efficacy of a Tailored COMET Protocol Combined with Medication on Vibratory Perception and SkinConductance in Diabetic Neuropathy- A Protocol for Randomized Controlled Trial [version 1; peer review: 1 approved, 1 not approved] . F1000Research 2024, 13 :344 ( https://doi.org/10.5256/f1000research.158656.r300797) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. 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