Contractility of late pregnant rat myometrium is refractory to activation of soluble but not particulate guanylate cyclase

Eva Fulep, Yuri P. Vedernikov, George R. Saade, Robert E. Garfield
In: American Journal of Obstetrics and Gynecology · 2001 · vol. 185(1) , pp. 158–162 · doi:10.1067/mob.2001.114871 · PMID:11483921 · W2024150556
article OA: closed CC0
View on OpenAlex View on PubMed View at publisher

Abstract

ObjectiveOur purpose was to compare the effects of agents activating particulate or soluble guanylate cyclases on the spontaneous contractile activity of the isolated pregnant rat uterus.Study designUterine rings from midpregnant (14-day) and late pregnant (21-day) rats were suspended in organ chambers to record spontaneous contractile activity. Concentration-response curves were obtained for the following natriuretic peptides: atrial, brain, and C-type; concentration-response curves were also obtained for diethylamine nitric oxide, 3-morpholino-sydnominine, and authentic nitric oxide.ResultsAll 3 natriuretic peptides inhibited spontaneous uterine contractions equally at midgestation and late gestation. The inhibitory effects of the nitric oxide donors diethylamine nitric oxide, 3-morpholino-sydnominine, and authentic nitric oxide were attenuated in uterine tissues from animals in late stages of pregnancy.ConclusionAgents activating either soluble or particulate guanylate cyclase inhibit contractions of uterine rings from midgestation rats, whereas the effects of soluble guanylate cyclase are attenuated at late pregnancy. Thus spontaneous uterine contractions are under the control of both soluble and particulate guanylate cyclases; the former is dependent on gestational age but the latter is not.

My notes (saved in your browser only)

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (28)

Source provenance

openalex
last seen: 2026-05-11T06:27:45.971503+00:00
unpaywall
last seen: 2026-07-31T06:42:51.797318+00:00
License: CC0 · commercial use OK