Signification of nitric oxide concentration in peritoneal fluid and serum of women with early endometriosis-associated infertility

Objective:To investigate the relation of nitric oxide(NO) and the pathogenesis of early endometriosis-associated infertility.Methods:The concentration of NO in peritoneal fluid and serum of 37 patients with early endometriosis-associated infertility (EMS group),28 patients with tubal infertility (Tubal group) and 20 patients without infertility (control group) were measured with 4,5-diaminofluorescein (DAF-2),a fluorescence indicator of NO that emits fluorescence in response to a reaction with NO.Results:The F/F0 which reflects the concentration of NO in peritoneal fluid of the control group , the tubal group and the EMS group respectively were (1.1 298±0.039 251)、(1.136 317±0.058 752)and(1.205 783±0.043 172).The F/F0 was statistically higher in the EMS group compared with the control group (P0.05) and the tubal group (P0.05).But the F/F0 didn't seem to be different between the tubal group and the control group(P0.05). The F/F0 in serum was(1.143 167±0.045 557)in the control group,(1.1 334±0.026 565) in the tubal group and (1.12 725±0.0 497)in the EMS group.The difference of NO concentration without statistical significance among the three group(P0.05).Conclusion:NO may play an important role in the pathogenesis of early endometriosis-associated and pathophysiology of endometriosis-associated infertility.