Influência do uso de contraceptivo hormonal sobre o perfil inflamatório do peritônio com endometriose

Endometriosis results from the abnormal implantation of endometrial tissue outside the uterine cavity and has an uncertain etiology. It mainly occurs with pain and infertility, the first choice for pain control is hormonal contraceptives (HC), although their action is not well established in the literature. The present study analyzed the influence of the use of HC on the inflammatory profile of the peritoneum of patients with endometriosis. This was a crosssectional study with laboratory analysis. The study took place in tertiary hospitals in southern Brazil, with sample collection from 65 patients, 42 with endometriosis (26 without HC and 16 with HC) and 23 without endometriosis. An interview was conducted with a questionnaire for clinical-demographic information, peritoneal lavage and biopsy of the peritoneum were collected. The samples were analyzed at the neuroscience laboratory to quantify the concentration of IL-10 (using ELISA’s method), the averages obtained were analyzed by ANOVA. The samples of peritoneal lavage with endometriosis showed a higher concentration of IL-10 than the control group (p ≤ 0.05) and statistical significance was obtained for the reduction of IL-10 in the peritoneal lavage of patients with endometriosis using HC (8.1 ± 7.4 pg/mL), compared to women with endometriosis without using HC (17.9 ± 10.5 pg/mL). Considering the stage of the disease, a higher level of IL-10 (p ≤ 0.05) was observed both in the initial stages (12.1 ± 10.5 pg/mL) and in the advanced stages (15.4 ± 9.7 pg/mL), in relation to the control (1.7 ± 1.8 pg/mL); being significantly higher in advanced endometriosis. This study contributes to fill gaps about the real influence of HC use in peritoneum affected by endometriosis and the behavior of inflammatory system in peritoneum’s profile in mild and minimal degree. Therefore, it reinforces the hypotheses of a higher concentration of IL-10 in moderate and severe stages.