Serum levels of monocyte chemoattractant protein-1,hepatocyte growth factor and transforming growth factor-β1 in patients with endometriosis

Objective To investigate serum levels of monocyte chemoattractant protein-1( MCP-1),hepatocyte growth factor( HGF), transforming growth factor-β1( TGF-β1) in patients with endometriosis( EMs) and their significance. Methods Sixty eight patients with EMs admitted in the hospital from January 2012 to December 2013 were enrolled in the study. According to the American Fertility Society revised score( r-AFS) 31 cases were classified as stage Ⅰ-Ⅱ and 37 as stage Ⅲ-Ⅳ;and according to dysmenorrhea score 42 cases had score 0-1 and 26 had score 2-3. Thirty patients with benign tumor served as disease control group and 20 healthy women as healthy control group. Serum levels of MCP-1,HGF and TGF-β1 were measured with ELISA method. The correlation of MCP-1,HGF and TGF-β1 levels with EMs stage and dysmenorrhea score was analyzed. Results Serum levels of MCP-1,HGF and TGF-β1 in EMs group were significantly higher than those in healthy control group and disease control group( P 0. 01),while there were no significant differences between healthy control group and disease control group( P 0. 05). As the EMs stage and dysmenorrhea score elevated,the levels of MCP-1 decreased significantly( P 0. 05),while the levels of HGF and T GF-β1 levels significantly increased( P 0. 01). Conclusion Serum MCP-1,HGF and T GF-β1levels are associated with the disease stage and severity of dysmenorrhea in patients with endometriosis.