Sleep reveals dynamics integrating and segregating movement and stimulus representations in V1

Sleep reveals dynamics integrating and segregating movement and stimulus representations in V1 | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Sleep reveals dynamics integrating and segregating movement and stimulus representations in V1 Eliezyer de Oliveira, Soyoun Kim, Tian Qiu, Adrien Peyrache, Renata Batista-Brito, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-1816540/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract The primary visual cortex (V1) encodes multidimensional representations of ongoing movements, and how these influence stimulus representations without interfering with visual processing is unknown. Here we addressed this question by using extracellular recordings in deep layers of mouse V1 to explore the relationship of movement and stimulus representations to intrinsic local circuit dynamics observed during non-REM (NREM) sleep. Movement and stimulus representations are concentrated in an intrinsic low-dimensional “on-manifold” subspace, where they interact additively. However, stimulus representations are also concentrated in a high-dimensional “off-manifold” subspace where interference from movement-evoked activity is minimized. Off-manifold coding comprises population-sparse stimulus-evoked activity in chorister neurons, revealing an unexpected link between dimensionality, chorister/soloist cells, and sparse coding. Our findings suggest that intrinsic dynamics constrain neuronal activity in V1 and provide a structured substrate balancing the integration and segregation of movement and stimulus representations. Intrinsic manifold Local circuit dynamics Movement representations Chorister neurons Sparse coding Full Text Additional Declarations There is NO Competing Interest. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-1816540","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":523868875,"identity":"2811ec91-9e4f-44e5-a244-95f201f9de04","order_by":0,"name":"Eliezyer de Oliveira","email":"","orcid":"https://orcid.org/0000-0002-9651-8570","institution":"Albert Einstein College of Medicine","correspondingAuthor":false,"prefix":"","firstName":"Eliezyer","middleName":"","lastName":"de Oliveira","suffix":""},{"id":523868876,"identity":"4b4e0b3e-f3c3-4997-a123-216e6e442a7e","order_by":1,"name":"Soyoun 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