Novel Tetrahydrocyclohepteneindole Derivatives Targeting Estrogen Receptor Alpha for the Treatment of Breast Cancer

Song Z, Zhendong Song, Steven H Liang
ACS medicinal chemistry letters · 2025 · vol. 16(6) , pp. 967–969 · doi:10.1021/acsmedchemlett.5c00283 · PMID:40529053 · PMC12169604
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This patent describes new tetrahydrocyclohepteneindole compounds that selectively inhibit estrogen receptor alpha, showing promise for treating ERα-related conditions like breast cancer.

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Abstract

This patent presents novel substituted tetrahydrocyclohepteneindole derivatives as selective estrogen receptor alpha (ERα) inhibitors. These compounds demonstrate potential for treating Erα-related diseases such as cancers, ovulatory dysfunction, endometriosis, and inflammation diseases.

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Condition tags

endometriosis

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SciLite annotations

chemicals 2
benzocycloheptene benzocycloheptene

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europepmc
last seen: 2026-08-23T06:15:12.370321+00:00
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Courtesy of the U.S. National Library of Medicine