Liesegang rings and endometriosis

Case report OA: closed CC0 ⤵ 9 in-corpus citations
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Liesegang rings, acellular ringlike structures typically found in inflamed tissue, were observed in three new cases associated with endometriosis and should be distinguished from benign or malignant processes.

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This case series describes the presence of Liesegang rings, which are acellular ringlike structures typically associated with inflammation or necrosis, within the female genital tract. The authors report three additional patients who exhibited these eosinophilic, sharply demarcated structures, noting that one case involved an endometriotic cyst adjacent to a well-differentiated endometrioid adenocarcinoma of the ovary. The study highlights that such findings in this anatomical region are closely related to endometriosis and must be carefully distinguished from benign or malignant pathological processes to avoid misdiagnosis. This paper is centrally about endometriosis — specifically the identification of Liesegang rings as a histological feature within endometriotic cysts and their differential diagnosis alongside ovarian malignancy.

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Abstract

Liesegang rings (LRs) are acellular, ringlike structures that may from within and around inflamed or necrotic tissue. LRs are most commonly found within the kidneys, synovium, and eyelid and in association with pelvic inflammatory disease and other infectious processes. LRs are only rarely found within the female genital tract, usually within endometriotic cysts or around areas of chronic inflammation. Three additional patients with LRs associated with endometriosis are described. In one of them, LRs occurred at the edge of an endometriotic cyst adjacent to a well-differentiated endometrioid adenocarcinoma of the ovary. All cases were characterized by the presence of multiple eosinophilic, sharply demarcated ringlike structures that were highlighted by the periodic acid-Schiff method. LRs within the female genital tract, which appear to be closely related to endometriosis, should be distinguished from both benign or malignant processes.
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Liesegang Rings and Endometriosis - Peter L. Perrotta - Frances W. Ginsburg - Cleo I. Siderides - Vinita Parkash Summary Liesegang rings (LRs) are acellular. ringlike structures that may form within and around inflamed or necrotic tissue. LRs are most commonly found within the kidneys, synovium, and eyelid and in association with pelvic inflammatory disease and other infectious processes. LRs are only rarely found within the female genital tract, usually within endometriotic cysts or around areas of chronic inflammation. Three additional patients with LRs associated with endometriosis are described. In one of them, LRs occurred at the edge of an endometriotic cyst adjacent to a well-differentiated endometrioid adenocarcinoma of the ovary. All cases were characterized by the presence of multiple eosinophilic, sharply demarcated ringlike structures that were highlighted by the periodic acid-Schiff method. LRs within the female genital tract, which appear to be closely related to endometriosis, should be distinguished from both benign or malignant processes.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Adenocarcinoma Adenocarcinoma Adenocarcinoma Adult Adult Cysts Cysts Cysts Endometriosis Endometriosis Eosinophils Eosinophils Eosinophils Female Female Humans Humans Necrosis Necrosis

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Cited by (4)

Cited by (4)

Source provenance

europepmc
last seen: 2026-10-21T06:16:17.486033+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-10-08T22:00:48.437354+00:00
unpaywall
last seen: 2026-10-21T06:41:41.500114+00:00
License: CC0 · commercial use OK