Mifepristone for treatment of endometriosis after conservative operation

Objective: To evaluate the clinical effect and side effect of mifepristone in treatment of endometriosis after conservative operation.Methods: Ninety-three women with endometriosis after conservative surgery were randomly divided into two groups: mifepristone group(33 cases,mifepristone 10 mg/d,6 months); gonadotropin releasing hormone agonist(GnRH-a) group(30 cases,hypodermically leuprorelin acetate 3.75 mg,once per twenty-eight days for 6 months);control group(30 cases did not receive any postoperative medical treatment).Results: Mifepristone group and GnRH-a group achieved similar significant relief of pelvic symptoms and signs(75.6% and 80%),compared with the control group 56.7%(P0.05).The cumulative recurrence rates of Mifepristone group and GnRH-a group were 9.1% and 6.6%,significant lower than that of the control group 40.0%(P0.01).There were no significant differences between Mifepristone and GnRH-a groups (P0.05).Conclusion:Mifepristone seems to be an effective,safe and convenient treatment for endometriosis with low-cost,good compliance and few side effects.