WITHDRAWN: Targeting CCDC90B restores intestinal stem cell function and ameliorates hyperuricemia induced intestinal dysfunction

WITHDRAWN: Targeting CCDC90B restores intestinal stem cell function and ameliorates hyperuricemia induced intestinal dysfunction | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article WITHDRAWN: Targeting CCDC90B restores intestinal stem cell function and ameliorates hyperuricemia induced intestinal dysfunction Xiuying Peng, Moxuan Li, Kaixuan Zeng, Wantong Lv, Shuai Huang, and 5 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7709255/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Editorial Note The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author. Editorial notes are used to provide important context regarding the topic of a preprint or to alert readers to potential issues concerning that preprint or a downstream publication associated with it. For more information on editorial notes, see our Editorial Policies . Abstract The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author. Biological sciences/Cell biology Health sciences/Gastroenterology Full Text The authors have withdrawn this preprint from Research Square. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7709255","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":553608550,"identity":"8003408c-9de7-4bc1-843b-a26cb023a744","order_by":0,"name":"Xiuying Peng","email":"","orcid":"","institution":"The Third Affiliated Hospital of Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Xiuying","middleName":"","lastName":"Peng","suffix":""},{"id":553608551,"identity":"d631aaec-3394-4393-93f0-b1de55b3a70a","order_by":1,"name":"Moxuan Li","email":"","orcid":"","institution":"Shenzhen Campus of Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Moxuan","middleName":"","lastName":"Li","suffix":""},{"id":553608552,"identity":"b0a50cf6-e05a-4480-9826-09c1147e39c9","order_by":2,"name":"Kaixuan Zeng","email":"","orcid":"","institution":"Shenzhen Campus of Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Kaixuan","middleName":"","lastName":"Zeng","suffix":""},{"id":553608553,"identity":"ae97414d-9da5-438c-b8f9-6aff2279e0ff","order_by":3,"name":"Wantong Lv","email":"","orcid":"","institution":"Shenzhen Campus of Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Wantong","middleName":"","lastName":"Lv","suffix":""},{"id":553608554,"identity":"50062c97-c010-4c95-abdd-6ebb3c3d2472","order_by":4,"name":"Shuai Huang","email":"","orcid":"","institution":"Shenzhen Campus of Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Shuai","middleName":"","lastName":"Huang","suffix":""},{"id":553608555,"identity":"dbe4576d-9d8a-447d-ac52-f583eadda6a0","order_by":5,"name":"Zhaopeng Chen","email":"","orcid":"","institution":"Shenzhen Campus of Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Zhaopeng","middleName":"","lastName":"Chen","suffix":""},{"id":553608556,"identity":"b89cbebc-b582-46c3-ab2a-f2e16db03d86","order_by":6,"name":"Yunwei Guo","email":"","orcid":"","institution":"The Third Affiliated Hospital of Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Yunwei","middleName":"","lastName":"Guo","suffix":""},{"id":553608557,"identity":"008a65fa-3dec-4fe8-ad61-fd7e79172f1f","order_by":7,"name":"Taoli Liu","email":"","orcid":"","institution":"The Seventh Affiliated Hospital of Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Taoli","middleName":"","lastName":"Liu","suffix":""},{"id":553608558,"identity":"6a329ef2-9c9a-4fb2-9319-eee3fc1fad4c","order_by":8,"name":"Fengping Zheng","email":"","orcid":"","institution":"The Third Affiliated Hospital of Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Fengping","middleName":"","lastName":"Zheng","suffix":""},{"id":553608559,"identity":"970d2641-c3cc-4893-9ccd-c4bb0925879d","order_by":9,"name":"Peng Huang","email":"data:image/png;base64,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","orcid":"","institution":"The Seventh Affiliated Hospital of Sun Yat-sen University","correspondingAuthor":true,"prefix":"","firstName":"Peng","middleName":"","lastName":"Huang","suffix":""}],"badges":[],"createdAt":"2025-09-25 06:08:27","currentVersionCode":2,"declarations":"","doi":"10.21203/rs.3.rs-7709255/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-7709255/v2","draftVersion":[],"editorialEvents":[],"editorialNote":"The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.","failedWorkflow":false,"files":[{"id":97187127,"identity":"61a0f396-6ed0-4783-b8d8-7ec0b7890fe8","added_by":"auto","created_at":"2025-12-01 18:05:10","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":191341,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7709255/v2/318b9dc7-3134-49e2-a68d-b18ce29590b4.pdf"},{"id":97187125,"identity":"6544a499-5d71-41c5-8bf6-d9db09ce58a5","added_by":"auto","created_at":"2025-12-01 18:05:08","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":191341,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7709255/v2/a480713d-0d14-4373-b3a7-66398bb60fa8.pdf"},{"id":97187126,"identity":"a91573ff-f6cf-4f0b-8818-a16b99964e7e","added_by":"auto","created_at":"2025-12-01 18:05:08","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":191341,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7709255/v2/cad478cf-4099-4740-a4d6-2af6ab65f97d.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"WITHDRAWN: Targeting CCDC90B restores intestinal stem cell function and ameliorates hyperuricemia induced intestinal dysfunction","fulltext":[{"header":"Full Text","content":"The authors have withdrawn this preprint from Research Square."}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":true,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":true,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-7709255/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7709255/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.","manuscriptTitle":"WITHDRAWN: Targeting CCDC90B restores intestinal stem cell function and ameliorates hyperuricemia induced intestinal dysfunction","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2025-12-01 18:05:00","doi":"10.21203/rs.3.rs-7709255/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2025-11-24 09:24:47","doi":"10.21203/rs.3.rs-7709255/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"dd50fc5b-e45d-4fcc-9cde-e20d5c2eb74b","owner":[],"postedDate":"December 1st, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":58909958,"name":"Biological sciences/Cell biology"},{"id":58909959,"name":"Health sciences/Gastroenterology"}],"tags":[],"updatedAt":"2025-12-01T18:05:00+00:00","versionOfRecord":[],"versionCreatedAt":"2025-12-01 18:05:00","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v2","identity":"rs-7709255","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7709255","identity":"rs-7709255","version":["v2"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}