Role of Bariatric Surgery in Patients With Endometrial Cancer: A Case Report and Review of Literature

Maliheh Arab, Azadeh Jafari Ashtiani, Behnaz Ghavami, Behnaz Nouri, Giti Noghabaei, Masoomeh Raoufi
In: Journal of Family & Reproductive Health · 2024 · vol. 18(2) , pp. 140–145 · doi:10.18502/jfrh.v18i2.15938 · PMID:39011410 · W4400038000
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-29 ⓘ

This report presents two morbidly obese endometrial cancer patients who underwent bariatric surgery before laparoscopic cancer removal, achieving favorable body mass index changes and no recurrence post-treatment.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-04 · read from full text ⓘ

This case report and literature review examines the clinical management of a patient with endometrial cancer who also presented with severe obesity, highlighting the therapeutic potential of bariatric surgery as an adjunctive treatment. The authors discuss how significant weight loss achieved through surgical intervention can improve metabolic profiles and potentially enhance outcomes for patients with hormone-dependent malignancies. While the paper emphasizes the benefits of addressing obesity in this oncological context, it notes that large-scale randomized controlled trials are lacking to definitively establish standardized protocols for combining these procedures. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

Objective: The standard surgery for endometrial cancer can be deferred in some situations, including morbid obesity, comorbidities, and the patient's desire for fertility. One of the options to improve patients' circumstances is bariatric surgery. Case report: This study presented two patients with stage IA, grade I endometrioid endometrial adenocarcinoma. Both patients had morbid obesity and had comorbidities. In case 1, because of fertility preservation, and in case 2, because of severe comorbidities, hormone therapy was started, followed by bariatric surgery after counseling patients. Both patients had acceptable changes in body mass index during follow-up, so cancer surgery through laparoscopy was done. Both patients did not need adjuvant therapy; months after cancer surgery, there is no recurrence, and their body mass index is also decreasing. Conclusion: Bariatric surgery can improve outcomes in patients with morbid obesity who suffer endometrial cancer.
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Publication Journal of Family & Reproductive Health Record type Journal article Published 26 June 2024 Authors Maliheh Arab | Azadeh Jafari Ashtiani | Behnaz Ghavami | Behnaz Nouri | Giti Noghabaei | Masoomeh Raoufi The publisher of this work supports multiple resolution. The work is available from the following locations: {'doi': '10.18502/jfrh.v18i2.15938', 'member_id': '7770', 'member': 'Knowledge E DMCC', 'container-title': 'Journal of Family & Reproductive Health', 'primary-resource': 'https://publish.kne-publishing.com/index.php/JFRH/article/view/15938', 'tld': 'kne-publishing.com', 'clearbit-logo': '/static/no_logo.svg', 'coaccess': [], 'multiple-resolution': [{'url': 'https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2688', 'tld': 'tums.ac.ir', 'clearbit-logo': '/static/no_logo.svg'}], 'type': 'JOURNAL ARTICLE', 'published_date': '26 June 2024', 'publication': 'Journal of Family & Reproductive Health', 'title': 'Role of Bariatric Surgery in Patients With Endometrial Cancer: A Case Report and Review of Literature', 'name': None, 'id': None, 'location': None, 'display_doi': 'https://doi.org/10.18502/jfrh.v18i2.15938', 'grant_info': None, 'grant_info_funders': None, 'grant_info_funder_ids': '', 'grant_info_type': None, 'multiple_lead_investigators': [], 'multiple_co_lead_investigators': [], 'multiple_investigators': [], 'finances': [], 'project_description': None, 'award_amount': None, 'award_start': None, 'funding_scheme': None, 'internal_award_number': None, 'editors': None, 'authors': 'Maliheh Arab | Azadeh Jafari Ashtiani | Behnaz Ghavami | Behnaz Nouri | Giti Noghabaei | Masoomeh Raoufi', 'chairs': None, 'supplementary_ids': None} https://doi.org/10.18502/jfrh.v18i2.15938 JSON XML

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chemicals 12
estrogen estrogen androgen estrone estrogen estrogen medroxyprogesterone acetate levonorgestrel megestrol megestrol hormone
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noordeloos 2009062

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