Evaluation of the influence of clinical risk factors on the performance of extracorporal fertilization programs

V. V. Likhacheva, Аркадий Геннадьевич Маркдорф, Л. Г. Баженова, А. Е. Власенко, S. V. Shramko
In: Bulletin of Siberian Medicine · 2018 · vol. 17(2) , pp. 49–59 · doi:10.20538/1682-0363-2018-2-49-59 · W2884632877
article OA: diamond CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-15 ⓘ

This study evaluated 3,969 IVF programs and found that female age over 30, repeat attempts, tubal factors with chronic endometritis, and uterine fibroids alongside tubal factors or adenomyosis significantly increased the risk of negative outcomes.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-07, 2026-07-15 · read from full text ⓘ

The paper evaluated how major clinical risk factors affected IVF outcomes in 3,969 women treated for infertility at a single human reproduction clinic in 2010–2015, using inclusion based on availability of procedural outcome data and focusing largely on women ≤34 years and mostly first IVF attempts. It found that female infertility etiologies commonly involved tubal factor (sometimes with chronic endometritis), endocrine factor, and external genital endometriosis and adenomyosis, and that uterine fibroids—while not considered the primary cause in this dataset—were more frequent in patients with adenomyosis and tubal factor associated with chronic endometritis, with quantified impacts of both individual and combined factors on negative IVF outcomes. The authors identified key risk factors as age >30 years, repeat attempts in women ≤30 compared with the first attempt, tubal infertility with chronic endometritis, and the presence of fibroids in the context of tubal factor with chronic endometritis or adenomyosis. This paper is centrally about endometriosis and adenomyosis within the IVF risk-factor context—specifically through reporting their role among female infertility causes and their association with fibroids and unfavorable IVF outcomes.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Purpose of the study . To assess the influence of main clinical risk factors on the effectiveness of the in vitro fertilization (IVF) program. Materials and methods . The study included 3,969 IVF programs conducted in the “Medica” clinic of the “Mother and Child” group of companies in Novokuznetsk for 2010–2015. The inclusion criterion was the availability of information on the results of the procedure conducted. Results. The structure of the considered risk factors was identified, their key features were identified: the majority of women who underwent IVF procedure were under the age of 34, inclusive, more than half of all procedures were performed at the first attempt. The main causes of female infertility were: tubal factor, including those associated with chronic endometritis, polycystic ovary syndrome, external genital endometriosis and adenomyosis. In a number of cases, as a concomitant gynecological disease, uterine fibroids have been extirpated, which is not the main cause of infertility, but the presence of which can influence the effectiveness of IVF programs. Statistically significantly more often, fibroids were found in adenomyosis and tubal factors associated with chronic endometritis. A quantitative assessment of the degree of influence of the considered risk factors on the effectiveness of IVF programs was considered, and the influence of both individual factors and their combination was considered. Conclusion. The main factors statistically significantly increasing the risk of a negative outcome of the program are: the age of a woman over 30; repeated attempt at the age of up to 30 years inclusive (in comparison with the first attempt); tubular factor associated with chronic endometritis; presence of uterine fibroids in the tubular factor associated with chronic endometritis; The presence of fibroids in the tubular factor, complicated by adenomyosis.
Full text 6,377 characters · extracted from oa-doi-fallback · click to expand
Оценка влияния клинических факторов на результативность программ экстракорпорального оплодотворения https://doi.org/10.20538/1682-0363-2018-2-49-59 Аннотация Цель исследования – изучить и оценить влияние основных клинических факторов на результативность программ экстракорпорального оплодотворения (ЭКО). Материалы и методы. В исследование включены 3 969 пациенток, проходивших лечение бесплодия методом ЭКО в клинике женского здоровья и репродукции человека «Медика» группы компаний «Мать и дитя» (г. Новокузнецк) в 2010–2015 гг. Критерием включения являлось наличие информации о результатах проведенной процедуры. Большинство женщин, которым проводилась процедура ЭКО, находились в возрасте до 34 лет включительно, больше половины всех проведенных процедур приходились на первую попытку. Результаты. Основными причинами женского бесплодия являлись: трубный фактор, в ряде случаев ассоциированный с хроническим эндометритом, эндокринный фактор, наружный генитальный эндометриоз и аденомиоз. У части пациенток в качестве сопутствующего гинекологического заболевания была выявлена миома матки, которая не считается основной причиной бесплодия, но ее наличие может оказывать влияние на результативность программ ЭКО. Статистически значимо чаще миома встречалась при аденомиозе и трубном факторе, ассоциированном с хроническим эндометритом. Дана количественная оценка степени влияния рассматриваемых факторов риска на результативность программ ЭКО, рассматривалось влияние как отдельных факторов, так и их сочетания. Выводы. Основными факторами риска отрицательного исхода программы ЭКО являются: возраст женщины более 30 лет; повторная попытка в возрасте до 30 лет включительно (по сравнению с первой попыткой); трубное бесплодие в ассоциации с хроническим эндометритом; наличие миомы матки при трубном факторе, ассоциированном с хроническим эндометритом или аденомиозом. Об авторах В. В. ЛихачеваРоссия канд. мед. наук, ассистент, кафедра акушерства и гинекологии, 654005, Кемеровская область, г. Новокузнецк, пр. Строителей, 15 А. Г. Маркдорф Россия канд. мед. наук, медицинский директор, 654041, Кемеровская область, г. Новокузнецк, ул. Сеченова, 30 Л. Г. Баженова Россия д-р мед. наук, профессор, зав. кафедрой акушерства и гинекологии, 654005, Кемеровская область, г. Новокузнецк, пр. Строителей, 15 А. Е. Власенко Россия канд. техн. наук, преподаватель, кафедра кибернетики и информатики, 654005, Кемеровская область, г. Новокузнецк, пр. Строителей, 15 С. В. Шрамко Россия канд. мед. наук, доцент, кафедра акушерства и гинекологии, 654005, Кемеровская область, г. Новокузнецк, пр. Строителей, 15 Список литературы 1. Bahamondes L., Makuch M.Y. Infertility care and the introduction of new reproductive technologies in poor resource settings. Reprod Biol Endocrinol. 2014; 8: 12–87. DOI: 10.1186/1477-7827-12-87. 2. Корсак В.С. Регистр центров ВРТ России. Отчет за 2014 год. СПб.: РАРЧ, 2016: 48. [Korsak V.S. Register of VRT centers in Russia. Report for the year 2014. St.-Petersburg: RARCH, 2016; 48 (in Russ.)]. 3. González-Foruria I., Peñarrubia J., Borràs A. Age, independent from ovarian reserve status, is the main prognostic factor in natural cycle in vitro fertilization. Fertil. Steril. 2016; 106: 342–347. DOI: 10.1016/j.fertnstert.2016.04.007. 4. Mcclintock S., Ma Z.Q., Rieger R.H. Incorrect inference in prevalence trend analysis due to misuse of the odds ratio. Ann. Epidemiol. 2016; 26(2): 136–140. DOI: 10.1016/j.annepidem.2015.12.009. 5. Базина М.И., Сыромятникова С.А., Емельянова Е.Ю., Савалова Н.С. Эффективность программ вспомогательных репродуктивных технологий у пациенток с трубным бесплодием в Красноярском крае. Доктор. Ру. 2015; 11: 8–12. [Bazina M.I., Syromyatnikova S.A., Emel’yanova E.Y., Savalova N.S. Efficiency of assisted reproductive technologies in patients with tubal infertility in the Krasnoyarsk Territory. Doktor.Ru. – Doktor.Ru. 2015; 11: 8–12 (in Russ.)]. 6. Kim H., Sung N., Song I., Predictors of live birth and pregnancy success after in vitro fertilization in infertile women aged 40 and over. Clin. Exp. Reprod. Med. 2017; 44(2): 111–117. DOI: 10.5653/cerm.2017.44.2.111. 7. Abrahamyan G. Results of preparation and implementation of ivf program in patients with thrombophilia and history of failed IVF. Georgian Med News. 2017; 268: 17–23. 8. Вартанян Э.В., Мартышкина Е.Ю., Цатурова К.А. Роль сочетанной патологии в неудачных протоколах ЭКО. Акушерство, гинекология и репродукция. 2011; 4: 25–43. [Vartanyan E.V., Martyshkina E.Y., Tsaturova K.A. The role of combined pathology in unsuccessful IVF protocols. Akusherstvo, ginekologiya i reproduktsiya – Obstetrics, gynecology and reproduction. 2011; 4: 25–43 (in Russ.)]. 9. Замаховская Л.Ю., Рудакова Е.Б., Трубникова О.Б. Факторы риска и профилактика ранних потерь беременности после ýкстракорпорального оплодотворения. Медицинский совет. 2016; 12: 88–94. [Zamakhovskaya L.Yu., Rudakova E.B., Trubnikova O.B. Risk factors and prevention of early loss of pregnancy after in vitro fertilization. Meditsinskiy sovet – Medical Council. 2016; 12: 88–94 (in Russ.)]. 10. Samejima T., Koga K., Nakae H., Wada-Hiraike O., Fujimoto A., Fujii T., Osuga Y. Identifying patients who can improve fertility with myomectomy. Eur. J. Obstet. Gynecol. Reprod. Biol. 2015; 185: 28–32. DOI: 10.1016/j. ejogrb.2014.11.033. 11. Yan L., Ding L., Li C., Wang Y., Tang R., Chen Z.J. Effect of fibroids not distorting the endometrial cavity on the outcome of in vitro fertilization treatment: a retrospective cohort study. Fertil. Steril. 2014; 101(3): 716–721. DOI: 10.1016/j.fertnstert.2013.11.023. 12. Zepiridis L.I., Grimbizis G.F., Tarlatzis B.C. Infertility and uterine fibroids. Best. Pract. Res. Clin. Obstet. Gynaecol. 2016; 34: 66–73. DOI: 10.1016/j.bpobgyn.2015.12.001. Рецензия Для цитирования: Лихачева В.В., Маркдорф А.Г., Баженова Л.Г., Власенко А.Е., Шрамко С.В. Оценка влияния клинических факторов на результативность программ экстракорпорального оплодотворения. Бюллетень сибирской медицины. 2018;17(2):49-59. https://doi.org/10.20538/1682-0363-2018-2-49-59 For citation: Likhacheva V.V., Markdorf A.G., Bazhenova L.G., Vlasenko A.E., Shramko S.V. Evaluation of the influence of clinical risk factors on the performance of extracorporal fertilization programs. Bulletin of Siberian Medicine. 2018;17(2):49-59. (In Russ.) https://doi.org/10.20538/1682-0363-2018-2-49-59 JATS XML

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosisadenomyosisinfertility

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (9)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK