An assessment of sequential measurements of immune complex levels in ovarian cancer patients with respect to clinical progress

Mooney NA, N A Mooney, Townsend PA, P A Townsend, Wiltshaw E, E Wiltshaw, Evans DG, D G Evans, K Shanti-Raju, Shanti-Raju K, Poulton TA, T A Poulton
Gynecologic Oncology · 1983 · vol. 15(2) , pp. 207–13 · doi:10.1016/0090-8258(83)90076-8 · PMID:6299906
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This study assessed sequential immune complex levels in ovarian cancer patients undergoing chemotherapy, finding that while levels correlated with tumor mass changes, they lacked clinical utility for patient evaluation.

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Abstract

An evaluation of immune-complex levels as an additional parameter in the clinical follow-up of ovarian cancer patients is described. These patients were treated aggressively with monthly chemotherapy following surgery. Sequential measurements of immune-complex levels have been carried out concurrently and clinical findings were recorded in a uniform manner suitable for comparison with the levels of immune complexes. The relationships between changes in tumor mass and changes in levels of immune complexes were investigated. A significant relationship between decreasing immune-complex levels and simultaneously decreasing tumor mass was found. Chemotherapy was associated with a decrease in immune-complex levels which increased again within 1 month. These data did not support an effective role for immune-complex levels in the evaluation of these patients.

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Condition tags

endometriosis

MeSH descriptors

Antigen-Antibody Complex Antineoplastic Agents Ovarian Neoplasms Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma, Mucinous Adenocarcinoma, Mucinous Adenocarcinoma, Mucinous Adenocarcinoma, Mucinous Adenocarcinoma, Mucinous Antigen-Antibody Complex Antigen-Antibody Complex Antineoplastic Agents Antineoplastic Agents Carcinoma, Papillary Carcinoma, Papillary Carcinoma, Papillary

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europepmc
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pubmed
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