Cross-sectional Study on the Association Between Hyperuricemia and Other Metabolic Diseases

Abstract Purpose: Hyperuricemia (HUA) is a metabolic disease caused by overproduction and/or underexcretion of serum uric acid (SUA). The study was conducted to find the association between Hyperuricemia and hypertension, diabetes and hyperlipidemia. Methods: A total of 1632 people aged older than 18 years were selected through cluster random sampling in 2015 from two hospitals in Qiqihar, China. Epidemiological investigations were conducted to determine SUA, blood pressure, blood lipids, blood glucose and other indicators. Statistical comparisons of the results were evaluated by using t test, chi-square test, and logistic regression analysis with SPSS 19.0. Results: The prevalence of HUA, hypertension, diabetes and hyperlipidemia were 21.68%, 37.26%, 10.98% and 57.45% in the male population and 1.34%, 19.91%, 4.59% and 40.38% in the female population, respectively. There was a significant difference in the prevalence of HUA, hypertension, diabetes and hyperlipidemia between males and females (p＜0.001). Using the lowest SUA range as a reference group, the risk of hyperlipidemia increased with SUA levels in population (Q2: OR=1.570, p=0.003; Q3: OR=2.049, p＜0.001; Q4: OR=3.519, p＜0.001). (This trend persisted after adjusting for BMI, sex and age, Q2: OR=1.632, p=0.002; Q3: OR=2.091, p＜0.001; Q4: OR=3.719, p＜0.001). However, there was no statistically significant difference between the levels of SUA in the context of diabetes and hypertension, not even been adjusted. Conclusion: The level of SUA is associated with hyperlipidemia. It may be useful to maintain normal SUA level in the prevention and treatment of hyperlipidemia.