Expression of PTEN gene in endometriosis of the ovary

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This study detected PTEN mRNA expression in ovarian endometriosis and normal ovary tissues, finding that expression levels differed significantly and correlated with disease staging but not patient age or cyst size.

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Abstract

The expression of PTEN mRNA was detected by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) in tissues of endometriosis and normal ovary. The difference between the relative expression level of PTEN mRNA exon 1-9 and 5-9 in tissues of endometriosis and normal ovary was statisatically significant (t=3.122, 2.209, P<0.01, 0.05). The expression level of PTEN mRNA in endometriosis of ovary was related to staging (t=2.678, 2.284, P0.05). PTEN gene inactivation may represent early events in the transformation of benign endometriotic cells to malignancy.

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europepmc
last seen: 2026-07-06T06:10:23.601157+00:00