Lean metabolic dysfunction–associated steatotic liver disease: A wolf in Sheep’s Clothing

Lean metabolic dysfunction–associated steatotic liver disease: A wolf in Sheep’s Clothing | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 16 April 2025 V1 Latest version Share on Lean metabolic dysfunction–associated steatotic liver disease: A wolf in Sheep’s Clothing Authors : Xixi Fang , Chenhao Xu , Jun Lu , Runzhou Zhuang , Xiao Xu , and Xuyong Wei 0000-0001-8755-5268 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174480521.18991962/v1 Published Cell Biochemistry and Function Version of record Peer review timeline 242 views 202 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) affects around 25% of the global population. It is expected to be the primary cause of end-stage liver disease and liver transplantation. Obesity is regarded as a major risk factor for MASLD. Still, there is a subset of MASLD patients who do not exhibit obesity-related traits, and this group is frequently neglected in clinical workups. It cannot be detected and treated immediately. More and more research has shown that MASLD is a multi-systemic disease that is linked not only to type-2 diabetes but also to end-stage liver disorders like cirrhosis, liver failure, hepatocellular carcinoma, cardiovascular disease, and chronic kidney disease. Furthermore, lean MASLD patients may be more likely to develop liver fibrosis and end-stage liver disease, as well as a higher risk of cardiovascular disease and mortality. Supplementary Material File (manuscript.docx) Download 68.00 KB Information & Authors Information Version history V1 Version 1 16 April 2025 Peer review timeline Published Cell Biochemistry and Function Version of Record 4 Nov 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords cardiovascular disease end-stage liver disorders lean masld liver transplantation macrophage Authors Affiliations Xixi Fang Hangzhou Normal University View all articles by this author Chenhao Xu Hangzhou First People's Hospital View all articles by this author Jun Lu Hangzhou First People's Hospital View all articles by this author Runzhou Zhuang The First Affiliated Hospital of Zhejiang University School of Medicine View all articles by this author Xiao Xu Affiliated People's Hospital of Hangzhou Medical College (Zhejiang Provincial People's Hospital View all articles by this author Xuyong Wei 0000-0001-8755-5268 [email protected] Hangzhou First People's Hospital View all articles by this author Metrics & Citations Metrics Article Usage 242 views 202 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Xixi Fang, Chenhao Xu, Jun Lu, et al. Lean metabolic dysfunction–associated steatotic liver disease: A wolf in Sheep’s Clothing. 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