Evaluation of the Anti-Inflammatory Impact of Vitamin D on Polycystic Ovary Syndrome and Endometriosis

Elif İşbilen, Özge Karuserci Kömürcü
In: Experimed · 2022 · vol. 12(2) , pp. 80–84 · doi:10.26650/experimed.1111483 · W4290805723
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This study evaluated the correlation between vitamin D levels and inflammatory markers NLR and PLR in women with PCOS and endometriosis, finding vitamin D negatively correlated with NLR in PCOS patients.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

The paper evaluates the anti-inflammatory effects of vitamin D in the context of polycystic ovary syndrome and endometriosis, comparing how vitamin D influences inflammatory measures relevant to these gynecologic conditions. The available text does not provide details on study design, participants, assays, or specific outcomes, and therefore the key findings and limitations cannot be determined from the excerpt. No explicit methodological caveats or results are described in the provided content. Relevance to endometriosis: the paper’s title and stated scope include endometriosis alongside polycystic ovary syndrome, with vitamin D’s anti-inflammatory impact examined in that context.

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Abstract

Objective: Although numerous studies demonstrate the link between vitamin D and its anti-inflammatory effects, the correlations could not be fully explained. Platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) are investigated as biomarkers for diagnosis and follow-up in various obstetrics and gynecological studies. We aimed to evaluate the correlation between the anti-inflammatory effect of vitamin D and inflammatory parameters NLR and PLR in women with polycystic ovary syndrome (PCOS) and endometriosis. Materials and Methods: Serum 25-hydroxy vitamin D (25(OH)D) levels, complete blood count (CBC) parameters, NLR, PLR, Vitamin B12, and thyroid stimulating hormone (TSH) levels of 140 patients who applied to the Department of Obstetrics and Gynecology between 2010-2019 were evaluated. In our study, the levels of 25(OH)D, TSH, vitamin B12 and CBC measurements were analyzed simultaneously. SPSS 22.0 Windows version software was utilized in the data analysis, and p<0.05 was accepted as statistical significance level. Results: There were significant differences in NLR (p=0.026) and lymphocytes count between PCOS and endometriosis groups (p=0.010). When we examined PCOS and endometriosis patients as a patient group; according to 25(OH)D vitamin levels, we found that NLR was significantly higher in the group with 25(OH)D vitamin levels below 20 ng/ml (p=0.017), vit B12 levels were significantly lower (p=0.034). Bivariate correlation analysis showed that vitamin D was negatively correlated with NLR (r=-0.196, p=0.050) in the patients with PCOS but not with endometriosis. Conclusion: This retrospective study assessed the association between vitamin D levels and the new inflammation biomarkers in patients with PCOS and endometriosis. The CBC and neutrophil/lymphocyte ratios are accessible and easily measurable biomarkers, therefore, evaluating the anti-inflammatory effect of vitamin D together with NLR is valuable for both PCOS and endometriosis.
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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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