Expression and significance of CD44v6,ICAM-1 and E-cadherin in endometriosis

Objective To investigate the role of CD44v6,ICAM-1 and E-cadherin in development of endmetriosis(EMs).Methods Immunohistochemical method was used to detect the expression of CD44v6,ICAM-1 and E-cadherin in the EMs eutopic,ectopic endometrium and normal endometrium.Results CD44v6 expression in ectopic endometrium was significantly higher than that in the eutopic endometrium and the normal endometrium(P0.05).ICAM-1 expression in the ectopic endometrium was higher than that in the eutopic endometrium,and ICAM-1 expression in the eutopic endometrium was higher than that in the normal endometrium(P0.05).E-cadherin expression in the ectopic endometrium and the eutopic endometrium decreased significantly than that in the normal endometrium(P0.05).Conclusion Higher expression of CD44v6 and ICAM-1 and lower expression of E-cadherin in ectopic and eutopic endometrium of EMs play an important role in the development of EMs.