CHARACTERISTICS OF CHANGES IN THE HORMONAL PROFILE OF FEMALE SEXUAL DYSFUNCTION AND GENITAL ENDOMETRIOSIS IN THE TREATMENT PROCESS

Vitamin D deficiency and hormonal disbalance could be involved in the development of endometriosis and female sexual dysfunction (FSD). The purpose of the study – to determine the characteristics of changes in the hormonal profile of women with FSD and external genital endometriosis. The evaluation of peptide, steroid hormones, vitamin D, and homocysteine level was conducted on the 5–7th days of the menstrual cycle at the beginning of the study and 3, 6, 9 months after the treatment. A value of p < 0.0085 was considered significant difference between the intervention group (n=70) and control group (healthy women, n=30) under comparison. Results. Statistical analysis (Friedman’s test) of the dynamics of laboratory indicators during the control periods in group I showed a significant gradual increase in the levels of dehydroepiandrosterone sulfate (DHEA-S), free testosterone, estradiol, progesterone, FSH, LH, and Vitamin D (p<0.001) and decrease – 17-ОНР, Prolactin, thyroid-stimulating hormone (TSH), antibodies to thyroperoxidase (Anti-TPO) and homocysteine (p<0.001) against the background of the treatment. Normalization of the level of vitamin D was observed starting at the 6th and 9th months of observation in 32.9% (n=23) and 80.0% (n=56) and was significantly higher compared to the 6th month – χ2 = 29.75, p<0.001. Reference values of the homocysteine level in the 1st group were also achieved starting from the 6th month, but the share of such women was only 20.0% (n=14). In the 9th month of treatment, the proportion of patients with normhomocysteinemia increased significantly to 38.6% (n=27), χ2 = 4.97, p=0.026. Dynamics of changes in the hormonal profile of the thyroid gland after 3 months was characterized by a significant decrease in the initial levels of TSH level (on the 3rd, 6th, 9th months, p<0.001). The optimization of female sexual function occurs in the 9th month of therapy and is accompanied by a reliable normalization of the index of sexual dysfunction. In this term, the indicator of the sexual dysfunction index approaches the norm (26.55), which is classified as a sign of the absence of female sexual dysfunction.