Effect of administration of GnRH agonist on pregnancy occurrence after the laparoscope surgery of endometriosis

Objective:To evaluate the effect of using GnRH agonist(GnRH-a)after the laparoscopyCLP)surgery for treatment of endometriosis.Methods:Eighty infertile patients with stage I-D endometriosis who underwent laparoscopy surgery were randomly divided into GnRH-a group(40 patients) and non-treatment group(40 patients).Seventy seven patients completed the trial.The pregnancy rate within 6 months after treatment was observed.Results:Twenty-six of the 77 infertile patients with endometriosis were pregnant within 6 months after the treatment and the total pregnancy rate was 33.8%.In non-treatment group,13 patients were pregnant in 166 cycles observed.The cycle pregnancy rate was 7.8%(13/166) and the average pregnancy interval time after surgery was(4.15+1.34) months.In GnRH-a group,13 patients were pregnant in 149 cycles observed.The cycle pregnancy rate was 8.7%(13/149) and the average pregnancy interval time was(2.61 ±1.56) months.Although there was no significant difference in cycle pregnancy rate,the average pregnancy interval time after LP surgery was significantly different(P 0.05) between the two groups.Conclusions:For infertile patients with stage I-I]endometriosis,the pregnancy interval time can be shorten by giving GnRH-a treatment for 3 months after the LP surgery,but the cumulative pregnancy rate is not significantly increased.