Physicochemical characterization of a lycopene-loaded mesoporous silica nanoparticle formulation

Physicochemical characterization of a lycopene-loaded mesoporous silica nanoparticle formulation | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Physicochemical characterization of a lycopene-loaded mesoporous silica nanoparticle formulation Gabriela Corrêa Carvalho, Gabriel Davi Marena, André Luiz Carneiro Soares do Nascimento, and 5 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-2524778/v3 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 12 Mar, 2024 Read the published version in Nano Select → Version 3 posted You are reading this latest preprint version Show more versions Abstract Lycopene (LYC), a carotenoid extracted mainly from tomatoes, has several biological properties, making its use desirable as a nutraceutical and pharmaceutical active ingredient. Among its various applications vulvovaginal candidiasis stands out. However, the use of LYC in therapy has limitations related to its solubility and stability. In this study, mesoporous silica nanoparticles (MSNs) are used to load and protect LYC from degradation. The exact amount of drug incorporated was determined by analytical techniques, such as high performance liquid chromatography (HPLC) and thermal analysis. For this we developed and validated an HPLC method for LYC quantification and evaluated LYC impregnation in MSNs, followed by thermogravimetry analysis (TGA). Differential scanning calorimetry (DSC) was also used in order to confirm drug incorporation. Additionally, an in vitro release study in simulated vaginal fluid was also carried out. The HPLC method was duly validated for the range of 26–125 µg/mL and proved to be suitable for LYC quantification. DSC measurements suggest an improvement in the stability of the impregnated drug, which was reinforced by the release assay. Overall, the developed method is suitable to quantify LYC-loaded porous materials enabling its use in vaginal applications. High performance liquid chromatography validation thermogravimetry lycopene mesoporous silica nanoparticles Full Text Additional Declarations The authors declare no competing interests. Supplementary Files APPENDIXA.docx GA.jpg Cite Share Download PDF Status: Published Journal Publication published 12 Mar, 2024 Read the published version in Nano Select → Version 3 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-2524778","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":191700591,"identity":"7ced5422-cd9e-4685-98b8-52ad215480cb","order_by":0,"name":"Gabriela Corrêa Carvalho","email":"data:image/png;base64,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","orcid":"","institution":"School of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903 Araraquara, Brazil; Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen Ant. 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