P01.02: Experimental study of lauromacrogol injection in treating endometrial cyst

To evaluate the therapeutical effect of lauromacrogol injection in treating endometrial cyst. Experimental endometrial cyst was surgically induced in 45 healthy female SD rats with autotransplantation. The volume of the cyst was calculated and recorded. 4 weeks later, second laparotomy showed 54 cysts successfully established which were divided into four groups randomly. The fluid of the cysts was sucked out and deferent concentrations of lauromacrogol injection (1%, 0.8% and 0.5%) injected into the cysts of group A, B and C, respectively. In group D, the fluid was sucked out and no drug was injected. The third laparotomy was performed 4 weeks later, the cyst volume was observed and recorded. Then the rats were sacrificed. The histopathological change of each cyst was observed under microscope. The wall of the induced cyst was thin and the blood vessels on the surface clearly visible. The epithelial cell, gland tissue and mesenchyma were clearly seen in the cyst wall and grew well on histopathologic observation. Before the treatment, the voluminal difference of each group has no significance (p > 0.05). Four weeks after treatment, the cystic volume of group A and B decreased remarkably (P 0.05). 1% lauromacrogol injection could decrease the cyst obviously and the depressant effect was significant; the depressant effect of 0.8% lauromacrogol injection was inferior to 1% lauromacrogol injection; the depressant effect of 0.5% lauromacrogol injection was little; the cysts without any intervention accreted after 4 weeks. Histopathologic observation showed that the epithelial, mesenchyma cells and glands of cyst wall in group A and B were atrophic while in the group C the endometrium grew well. Lauromacrogol injection could make the volume of induced endometrial cyst decrease significantly, restrain the growth of the cyst. The inhibition rate was related to the concentration of the injection.