PREVALENCE AND OUTCOME OF CLEAR CELL CARCINOMA AND ENDOMETRIOID CARCINOMA OF OVARY COEXISTING WITH ENDOMETRIOSIS

PREVALENCE AND OUTCOME OF CLEAR CELL CARCINOMA AND ENDOMETRIOID CARCINOMA OF OVARY COEXISTING WITH ENDOMETRIOSIS Jitima Tiyayon*, Raweewan Promsila***Department of Obstetrics and Gynaecology, Rajavithi Hospital, College of Medicine Rangsit University**Department of Obstetrics and Gynaecology, Sawanpracharak HospitalAbstractObjectives. The association between endometriosis and ovarian carcinoma has been widely proposed. We retrospectively evaluated clinical manifestation, surgical outcome and complication of endometriosis-associated ovarian cancer compare to non-endometriosis-associated ovarian cancer with histologic type of clear cell carcinoma and endometrioid carcinoma.Methods. The study was conducted to review 330 patients with primary ovarian clear cell carcinoma and endometrioid carcinoma who had been initially treated at Rajavithi Hospital. The clinical backgrounds, surgical outcome and complication was reviewed.Results. 13.51% had pathological-confirmed coexisting endometriosis in clear cell carcinoma and endometrioid carcinoma. 76.57% of endometriosis-associated ovarian cancer (EAOC) presented with earlier stage (stage I-II) than non-EAOC. The higher probability of optimally surgical staging was reported in EAOC compare to non-EAOC with statistically significance (77.8% versus 54.7% respectively, p=0.002). Post-operative complication was also lower in EAOC (p=0.02). There was no difference on age, stage and surgical outcome between clear cell carcinoma and endometrioid carcinoma associated with endometriosis.Conclusion. Endometriosis-associated ovarian cancer related to early-stage disease and tend to underwent optimal surgery. The operative complication seemed to be lower in endometriosis-associated ovarian cancer.