Expression and significance of Bax and E2F-1 in human adenomyosis
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Adenomyosis eutopic endometrium exhibited significantly higher expression of apoptosis regulators Bax and E2F-1 compared to normal endometrium.
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Abstract
Objective:To study the pathophysiological effect of expression of apoptosis regulating protein Bax and transcription factor E2F-1 in human adenomyosis. Methods:Immunohistochemical SP method was employed to detect the expression of Bax and E2F -1 in 72 specimens of eutopic endometrium of adenomyosis and 55 specimens of normal endometrium. Results:The expressions of Bax and E2F-1 in eutopic endometrium of adenomyosis were significantly higher than those of normal endometrium (P0.05). The expression of Bax or E2F-1 in eutopic endometrium was the same as ectopic endometrium of adenomyosis (P0.05). Conclusion:The abnormal expression of Bax and E2F-1 may be correlated with the pathogenesis of human adenomyosis.
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- last seen: 2026-06-04T00:00:01.174412+00:00
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