Airway Intervention in Pediatric Angioedema: A National Analysis of Clinical Predictors and Outcomes

Airway Intervention in Pediatric Angioedema: A National Analysis of Clinical Predictors and Outcomes | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 8 September 2025 V1 Latest version Share on Airway Intervention in Pediatric Angioedema: A National Analysis of Clinical Predictors and Outcomes Authors : Saharsh Talwar 0009-0007-1552-1502 [email protected] , Aryan Mahajan , Gaurav N. Pathak , Babar K. Rao , and Rachel Kaye Authors Info & Affiliations https://doi.org/10.22541/au.175731318.86995814/v1 177 views 93 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Objective: To characterize pediatric hospitalizations for angioedema and identify the prevalence and outcomes of airway interventions using a large national database. Methods: We performed a cross-sectional analysis of the Kids’ Inpatient Database (2003–2019), including pediatric patients (0–20 years) hospitalized with angioedema identified by ICD-9/10 codes. Outcomes included hospital length of stay (LOS), total charges, and in-hospital mortality. Multivariable logistic regression evaluated predictors of airway intervention, and comparative analyses assessed outcome differences between patients with and without airway procedures. Results: Among 4,238 pediatric angioedema hospitalizations, 174 (4.1%) underwent airway procedures. Compared to non-intervention cases, these patients had significantly longer LOS (median 6 vs. 2 days, p < 0.001), higher charges ($59,571 vs. $7,628, p < 0.001), and higher mortality (5.8% vs. 0.15%, p < 0.001). Black (adjusted odds ratio [AOR] 5.23, 95% CI 1.56–19.30) and Hispanic race (AOR 7.83, 95% CI 1.51–44.89) were associated with higher odds of intervention, while hospitalizations in the Northeast (AOR 0.10, 95% CI 0.015–0.55) and South (AOR 0.13, 95% CI 0.03–0.49) had lower odds compared to the Midwest. Conclusion: Airway interventions in pediatric angioedema are rare but linked to significantly higher morbidity, mortality, and healthcare costs. Geographic and racial disparities highlight the need to explore systemic factors shaping airway management decisions. Supplementary Material File (final pediatric angioedema - clinical otolaryngology (2).docx) Download 25.98 KB Information & Authors Information Version history V1 Version 1 08 September 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Affiliations Saharsh Talwar 0009-0007-1552-1502 [email protected] Rutgers Robert Wood Johnson Medical School View all articles by this author Aryan Mahajan Rutgers Robert Wood Johnson Medical School View all articles by this author Gaurav N. Pathak Rutgers Robert Wood Johnson Medical School View all articles by this author Babar K. Rao Rutgers Robert Wood Johnson Medical School View all articles by this author Rachel Kaye Rutgers New Jersey Medical School View all articles by this author Metrics & Citations Metrics Article Usage 177 views 93 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Saharsh Talwar, Aryan Mahajan, Gaurav N. Pathak, et al. Airway Intervention in Pediatric Angioedema: A National Analysis of Clinical Predictors and Outcomes. Authorea . 08 September 2025. DOI: https://doi.org/10.22541/au.175731318.86995814/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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