The Role of Serum and Urine CRP Levels in Predicting Pathology Results in Patients Undergoing Prostate Biopsy

The Role of Serum and Urine CRP Levels in Predicting Pathology Results in Patients Undergoing Prostate Biopsy | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article The Role of Serum and Urine CRP Levels in Predicting Pathology Results in Patients Undergoing Prostate Biopsy Cihat Genç, Erkan Erkan, Uğur Yücetaş, Semih Aktaş, Esma Yücetaş This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6545712/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Objective: The definitive diagnosis of prostate cancer, the second most common cancer in men, relies on histopathological examination of tissue obtained through prostate biopsy. Prostate biopsy, typically performed transrectally and occasionally via transperineal routes, carries a range of complication risks from psychological stress to hematuria and urosepsis. Avoiding unnecessary prostate biopsies is crucial. In this context, CRP, an inflammatory marker, may help prevent unnecessary biopsies related to PSA increases due to non-neoplastic local inflammatory causes. Based on this hypothesis, our study aimed to evaluate the role of urine and serum CRP levels in predicting possible pathology results (BPH, chronic prostatitis, and PCa) in patients planned for prostate biopsy. Materials and Methods: A total of 251 patients who presented to the urology clinic at Istanbul Training and Research Hospital between 01/09/2023 and 31/01/2023 and underwent biopsy were included in the study. Patients had normal urine tests at presentation, serum total PSA levels between 2.5-10 ng/dl, and normal digital rectal examination findings. Urine and blood samples were collected to determine pre-biopsy CRP levels, which were centrifuged and stored at -80 degrees; appropriate serum and urine kits were used for analysis. Following this, TRUS-Bx was performed under suitable conditions. Based on histopathological results, patients were divided into three groups: BPH, chronic prostatitis, and PCa. Measurements and evaluations were conducted regarding comorbidities (HT, CVD, COPD, DM, etc.), BMI, smoking status, PSA, PV, and urine and serum CRP levels. Results were analyzed statistically, and comparisons among the groups were made. Results: When examining the relationship between demographic characteristics, comorbidity groups, and CRP levels, no significant difference was found in serum and urine CRP levels (p>0.05). In the histopathological subgroup analysis (BPH, chronic inflammation, PCa), it was observed that urine and serum CRP levels were not related to comorbidity, weight, height, BMI, or smoking status (p>0.05). While a significant difference was observed in PV among the three groups (P=0.00), no difference was found regarding PSA levels. No significant difference was determined in serum and urine CRP levels among the three study groups. Conclusion : According to the findings of our study, urine and serum CRP levels prior to TRUS-BX for suspected prostate cancer do not provide additional benefit in predicting benign or malignant pathology results. Nonetheless, further larger and comprehensive studies supported by advanced imaging techniques are needed. serum CRP urine CRP prostate biopsy prostate cancer chronic inflammation Full Text Additional Declarations No competing interests reported. Supplementary Files veri.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6545712","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":450046716,"identity":"ddf5c558-e01c-42d3-82e2-f626432eddfd","order_by":0,"name":"Cihat 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Biopsy","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"serum CRP, urine CRP, prostate biopsy, prostate cancer, chronic inflammation","lastPublishedDoi":"10.21203/rs.3.rs-6545712/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6545712/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eObjective:\u003c/strong\u003e The definitive diagnosis of prostate cancer, the second most common cancer in men, relies on histopathological examination of tissue obtained through prostate biopsy. Prostate biopsy, typically performed transrectally and occasionally via transperineal routes, carries a range of complication risks from psychological stress to hematuria and urosepsis. Avoiding unnecessary prostate biopsies is crucial. In this context, CRP, an inflammatory marker, may help prevent unnecessary biopsies related to PSA increases due to non-neoplastic local inflammatory causes. Based on this hypothesis, our study aimed to evaluate the role of urine and serum CRP levels in predicting possible pathology results (BPH, chronic prostatitis, and PCa) in patients planned for prostate biopsy.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMaterials and Methods:\u003c/strong\u003e A total of 251 patients who presented to the urology clinic at Istanbul Training and Research Hospital between 01/09/2023 and 31/01/2023 and underwent biopsy were included in the study. Patients had normal urine tests at presentation, serum total PSA levels between 2.5-10 ng/dl, and normal digital rectal examination findings. Urine and blood samples were collected to determine pre-biopsy CRP levels, which were centrifuged and stored at -80 degrees; appropriate serum and urine kits were used for analysis. Following this, TRUS-Bx was performed under suitable conditions. Based on histopathological results, patients were divided into three groups: BPH, chronic prostatitis, and PCa. Measurements and evaluations were conducted regarding comorbidities (HT, CVD, COPD, DM, etc.), BMI, smoking status, PSA, PV, and urine and serum CRP levels. Results were analyzed statistically, and comparisons among the groups were made.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e When examining the relationship between demographic characteristics, comorbidity groups, and CRP levels, no significant difference was found in serum and urine CRP levels (p\u0026gt;0.05). In the histopathological subgroup analysis (BPH, chronic inflammation, PCa), it was observed that urine and serum CRP levels were not related to comorbidity, weight, height, BMI, or smoking status (p\u0026gt;0.05). While a significant difference was observed in PV among the three groups (P=0.00), no difference was found regarding PSA levels. No significant difference was determined in serum and urine CRP levels among the three study groups.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion\u003c/strong\u003e: According to the findings of our study, urine and serum CRP levels prior to TRUS-BX for suspected prostate cancer do not provide additional benefit in predicting benign or malignant pathology results. Nonetheless, further larger and comprehensive studies supported by advanced imaging techniques are needed.\u003c/p\u003e","manuscriptTitle":"The Role of Serum and Urine CRP Levels in Predicting Pathology Results in Patients Undergoing Prostate Biopsy","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-05-06 04:21:47","doi":"10.21203/rs.3.rs-6545712/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"ad2d4096-62a8-4445-ae2d-c9b75241fb4b","owner":[],"postedDate":"May 6th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-07-18T10:39:14+00:00","versionOfRecord":[],"versionCreatedAt":"2025-05-06 04:21:47","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6545712","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6545712","identity":"rs-6545712","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}