Challenging Skull Base Lesions: A Neurosurgical Perspective

Challenging Skull Base Lesions: A Neurosurgical Perspective | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Challenging Skull Base Lesions: A Neurosurgical Perspective Harsh Patel, Preeti Singh, Abhaya Kumar This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6404005/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Lesions in the skull base represent a significant diagnostic and therapeutic challenge due to the complex anatomy of the area. Their close proximity to critical neural and vascular structures makes them potentially life-threatening, and their deep location complicates both diagnosis and treatment. Most skull base lesions are benign and don’t spread to other parts of the body. We present 2 challenging cases we faced first case is 62 year old immunocompetent male, radiological investigation suggestive of skull base lesion but upon further investigation it was found to be high grade intracranial glioma invading skull base and second case is of young 19 year female who was diagnosed with primary extraosseous intracranial Ewing's sarcoma, also known as a peripheral primitive neuroectodermal tumor or "small round blue cell tumor," is an extremely rare entity with only 9 cases reported in the literature till date. Early detection, careful planning, and a multidisciplinary approach are essential for effective management, with the goal of maximizing the patient's functional outcomes and quality of life. Histopathological misdiagnosis can lead to devastating consequences of late treatment and disease progression therefore close follow up and reviewing of tissue blocks may be required as sometimes key histopathological features get masked by extensive fibrosis. therefore continuous reevaluation of the pathology, especially in the case of unexpected changes in the patient’s condition is crucial. Skull Base Intracranial Extraosseous Neuroectodermal Functional Full Text Additional Declarations Consent to publish was obtained from the participants in the study. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6404005","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":441012166,"identity":"2eaa8443-6750-4512-b2ca-9120d5636fb0","order_by":0,"name":"Harsh Patel","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAx0lEQVRIiWNgGAWjYBACAwbmgw8SDCTkQJwDD4jTwpZs8KDCxhisJYE4LTxmgg/OpCU2gHhEaTGXbktjSGw7nD4/7PBDoC12croNBLRYzjl87AFQS+7G22kGQC3JxmYHCDnsRlq6AVjL7ASQlgOJ2whryTGTADnMcHb6BxK0JJxJS5CXziHWljvHkg0SKmwMN0jnFBxIMCDGL7ebDz78YSAhLz87ffOHDxV2cgS1MEjA9IJVGhBSjqxFvoEY1aNgFIyCUTAiAQDAzU27VpaInwAAAABJRU5ErkJggg==","orcid":"","institution":"Kokilaben Dhirubhai Ambani Hospital \u0026 Research Institute","correspondingAuthor":true,"prefix":"","firstName":"Harsh","middleName":"","lastName":"Patel","suffix":""},{"id":441012167,"identity":"780b1cb1-afae-491f-9505-98f000c618f4","order_by":1,"name":"Preeti Singh","email":"","orcid":"","institution":"Kokilaben Dhirubhai Ambani Hospital \u0026 Research Institute","correspondingAuthor":false,"prefix":"","firstName":"Preeti","middleName":"","lastName":"Singh","suffix":""},{"id":441012168,"identity":"e0c3598d-1ebb-4013-b031-cc7dbc8a5946","order_by":2,"name":"Abhaya Kumar","email":"","orcid":"","institution":"Kokilaben Dhirubhai Ambani Hospital \u0026 Research Institute","correspondingAuthor":false,"prefix":"","firstName":"Abhaya","middleName":"","lastName":"Kumar","suffix":""}],"badges":[],"createdAt":"2025-04-08 13:53:13","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6404005/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6404005/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":80984944,"identity":"3e4895e5-1e33-4912-afea-451b28d1448f","added_by":"auto","created_at":"2025-04-20 22:31:31","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":381977,"visible":true,"origin":"","legend":"","description":"","filename":"SKULLBASEF12.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6404005/v1_covered_85ffaff2-1f06-412c-81e8-b9bd351b59b4.pdf"}],"financialInterests":"\u003cp\u003eConsent to publish was obtained from the participants in the study.\u003c/p\u003e","formattedTitle":"Challenging Skull Base Lesions: A Neurosurgical Perspective","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Skull Base, Intracranial, Extraosseous, Neuroectodermal, Functional","lastPublishedDoi":"10.21203/rs.3.rs-6404005/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6404005/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eLesions in the skull base represent a significant diagnostic and therapeutic challenge due to the complex anatomy of the area. 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