COUP-TF orphan nuclear receptors in development and differentiation.

Pereira FA, Tsai MJ, Tsai SY
Cellular and molecular life sciences : CMLS · 2000 · doi:10.1007/pl00000624 · PMID:11078018 · PMC11147009
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This review article examines the Chicken ovalbumin upstream promoter transcription factors (COUP-TFs), which are orphan nuclear receptors that negatively regulate several other hormone receptors. The text highlights that these genes are highly conserved across species and play essential roles in embryogenesis and differentiation, as evidenced by studies in Drosophila and mice. Despite overlapping expression patterns, COUP-TFs are identified as critical regulators of development and physiological function in multiple organisms. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are orphan members of the steroid/thyroid hormone receptor superfamily. They have been shown to negatively regulate the activation function of vitamin D, thyroid hormone, retinoic acid, the retinoid X and the peroxisome proliferator-activated receptors. COUP-TF genes have been cloned from many species and their sequences are exceptionally conserved through evolution. This suggests a critical role for the COUP-TFs in these organisms. Indeed, the Drosophila COUP-TF, seven-up and mouse COUP-TFII are essential for development and differentiation during embryogenesis. Our current understanding of COUP-TF function suggests that they serve vital physiological roles during development despite extensive overlaps of expression. This defines the COUP-TFs as important factors in regulation of development and differentiation in multiple organisms.
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Abstract. Chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are orphan members of the steroid/thyroid hormone receptor superfamily. They have been shown to negatively regulate the activation function of vitamin D, thyroid hormone, retinoic acid, the retinoid X and the peroxisome proliferator-activated receptors. COUP-TF genes have been cloned from many species and their sequences are exceptionally conserved through evolution. This suggests a critical role for the COUP-TFs in these organisms. Indeed, the Drosophila COUP-TF, seven-up and mouse COUP-TFII are essential for development and differentiation during embryogenesis. Our current understanding of COUP-TF function suggests that they serve vital physiological roles during development despite extensive overlaps of expression. This defines the COUP-TFs as important factors in regulation of development and differentiation in multiple organisms. Keywords: Key words. Orphan nuclear receptors; COUP-TF; embryogenesis. Footnotes Received 20 December 1999; received after revision 2 March 2000; accepted 2 March 2000

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